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- W2720192928 abstract "The present work on the antioxidant activity of aqueous and methanolic extracts of Cucumis dipsaceous fruit is the first investigation. The results obtained in the in vitro models such as Reducing power assay, DPPH radical scavenging activity, Superoxide anion radical scavenging activity, Nitric oxide scavenging assay, and Metal ion chelating activity clearly suggest that, both the aqueous and methanolic extracts showed strong antioxidant activity when compared with different standards such as BHA, EDTA and Curcumin. In the present investigation, the sample and BHA showed significant effects on the DPPH radical scavenging at all amounts. The IC50 values of methanolic, aqueous extract and BHA were 66, 77.5 and 7μg/ml respectively. Inhibition of superoxide scavenging by aqueous and methanolic extracts showed concentrations dependent manner with an IC50 values of 137 and 287μg/ml respectively. methanolic extract was a potent superoxide anion scavenger than the aqueous extract. The reducing capacity was exhibited by both aqueous and methanolic extracts at all amounts. The reducing power of aqueous extract was higher than the methanolic extract. The ferrous ion chelating effect was shown by both of aqueous and methanolic extracts with IC50 values of 251 and 282μg/ml respectively. The positive control EDTA showed the IC50 value of 178μg/ml. The test samples were investigated for their inhibitory effects on nitric oxide production. The metahnolic extract showed significant free radical scavenging action against nitric oxide (NO) induced release of free radicals (IC50 = 32 μg/ml) than aqueous extract (IC50 = 44 μg/ml). In aqueous and methanolic extracts of Cucumis dipsaceous, 31.5 ± 2 and 43.1 ± 3.1 mg (gallic acid equivalent per gram) of phenols were detected respectively. There is little correlation between antioxidant activity and phenol content. Key words: Cucumis dipsaceous, antioxidant activity, reducing power, metal ion chelation, free radical scavenging activity." @default.
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- W2720192928 date "2017-03-31" @default.
- W2720192928 modified "2023-09-24" @default.
- W2720192928 title "Evaluation of the antioxidant activity of Cucumis dipsaceus" @default.
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