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- W2720405934 startingPage "2339" @default.
- W2720405934 abstract "In mitosis, cells undergo a precisely orchestrated series of spatiotemporal changes in cytoskeletal structure to divide their genetic material. These changes are coordinated by a sophisticated network of protein–protein interactions and posttranslational modifications. In this study, we report a bifurcation in a signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 that is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14. We demonstrate that a Nek9, Nek6, and Mklp2 signaling module controls the timely localization and bundling activity of Mklp2 at the anaphase central spindle. We further show that a separate Nek9, Nek7, and Kif14 signaling module is required for the recruitment of the Rho-interacting kinase citron to the anaphase midzone. Our findings uncover an anaphase-specific function for these effector kinesins that is controlled by specific Nek kinase signaling modules to properly coordinate cytokinesis." @default.
- W2720405934 created "2017-06-30" @default.
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- W2720405934 date "2017-06-19" @default.
- W2720405934 modified "2023-10-16" @default.
- W2720405934 title "A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase" @default.
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- W2720405934 doi "https://doi.org/10.1083/jcb.201512055" @default.
- W2720405934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5551695" @default.
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