Matches in SemOpenAlex for { <https://semopenalex.org/work/W272115035> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W272115035 endingPage "101.6" @default.
- W272115035 startingPage "101.6" @default.
- W272115035 abstract "Abstract Autoimmune liver diseases are characterized by elevated serum levels of IL-6. We have previously reported the development of a PBC-like model in dnTGF-βRII mice engineered to express a dominant negative form of transforming growth factor β receptor (dnTGF-βRII, dnR) under the control of CD4 promoter. By producing a double construct, namely IL-6 deficient mice on the dnTGF-βRII background (dnTGFβRII IL-6-/- mice), we previously reported that such animals manifest improvement in their underlying inflammatory bowel disease but worsening of their biliary infiltrates. To further understand this model, we have studied dnTGFβRII IL-6-/- mice and, in particular, focused on the pathology over a longer period of observation of up to 9 months. Importantly, loss of the IL-6 gene, although it does improve underlying inflammatory bowel disease, dramatically increases lymphoid aggregation, elevates inflammatory liver cytokines and promotes the appearance of activated T cells in liver. Indeed, loss of the IL-6 gene results in lymphomatous lesions in liver, spleen and lung at 6-9 months of age in 7 of 22 male dnTGFβRII IL-6-/- mice. No lesions were found in control dnTGFβRII mice. These data further highlight the promiscuous role of IL-6 and suggest caution in the therapeutic use of anti-IL6R antibody in the treatment of patients with autoimmune disease." @default.
- W272115035 created "2016-06-24" @default.
- W272115035 creator A5013188999 @default.
- W272115035 creator A5016565634 @default.
- W272115035 creator A5020774708 @default.
- W272115035 creator A5026873284 @default.
- W272115035 creator A5039708803 @default.
- W272115035 creator A5064443404 @default.
- W272115035 creator A5066462726 @default.
- W272115035 creator A5067842454 @default.
- W272115035 creator A5069672814 @default.
- W272115035 creator A5073313443 @default.
- W272115035 creator A5090529676 @default.
- W272115035 date "2011-04-01" @default.
- W272115035 modified "2023-10-16" @default.
- W272115035 title "Deletion of IL-6 in a murine model of primary biliary cirrhosis leads to exacerbated autoimmune cholangitis and lymphomas (101.6)" @default.
- W272115035 doi "https://doi.org/10.4049/jimmunol.186.supp.101.6" @default.
- W272115035 hasPublicationYear "2011" @default.
- W272115035 type Work @default.
- W272115035 sameAs 272115035 @default.
- W272115035 citedByCount "0" @default.
- W272115035 crossrefType "journal-article" @default.
- W272115035 hasAuthorship W272115035A5013188999 @default.
- W272115035 hasAuthorship W272115035A5016565634 @default.
- W272115035 hasAuthorship W272115035A5020774708 @default.
- W272115035 hasAuthorship W272115035A5026873284 @default.
- W272115035 hasAuthorship W272115035A5039708803 @default.
- W272115035 hasAuthorship W272115035A5064443404 @default.
- W272115035 hasAuthorship W272115035A5066462726 @default.
- W272115035 hasAuthorship W272115035A5067842454 @default.
- W272115035 hasAuthorship W272115035A5069672814 @default.
- W272115035 hasAuthorship W272115035A5073313443 @default.
- W272115035 hasAuthorship W272115035A5090529676 @default.
- W272115035 hasConcept C126322002 @default.
- W272115035 hasConcept C142724271 @default.
- W272115035 hasConcept C159654299 @default.
- W272115035 hasConcept C203014093 @default.
- W272115035 hasConcept C2776029263 @default.
- W272115035 hasConcept C2777203481 @default.
- W272115035 hasConcept C2777214474 @default.
- W272115035 hasConcept C2777714996 @default.
- W272115035 hasConcept C2778260677 @default.
- W272115035 hasConcept C2779075594 @default.
- W272115035 hasConcept C2779134260 @default.
- W272115035 hasConcept C2780366471 @default.
- W272115035 hasConcept C2780931953 @default.
- W272115035 hasConcept C71924100 @default.
- W272115035 hasConceptScore W272115035C126322002 @default.
- W272115035 hasConceptScore W272115035C142724271 @default.
- W272115035 hasConceptScore W272115035C159654299 @default.
- W272115035 hasConceptScore W272115035C203014093 @default.
- W272115035 hasConceptScore W272115035C2776029263 @default.
- W272115035 hasConceptScore W272115035C2777203481 @default.
- W272115035 hasConceptScore W272115035C2777214474 @default.
- W272115035 hasConceptScore W272115035C2777714996 @default.
- W272115035 hasConceptScore W272115035C2778260677 @default.
- W272115035 hasConceptScore W272115035C2779075594 @default.
- W272115035 hasConceptScore W272115035C2779134260 @default.
- W272115035 hasConceptScore W272115035C2780366471 @default.
- W272115035 hasConceptScore W272115035C2780931953 @default.
- W272115035 hasConceptScore W272115035C71924100 @default.
- W272115035 hasIssue "1_Supplement" @default.
- W272115035 hasLocation W2721150351 @default.
- W272115035 hasOpenAccess W272115035 @default.
- W272115035 hasPrimaryLocation W2721150351 @default.
- W272115035 hasRelatedWork W1982263271 @default.
- W272115035 hasRelatedWork W2000356017 @default.
- W272115035 hasRelatedWork W2043546341 @default.
- W272115035 hasRelatedWork W2045127102 @default.
- W272115035 hasRelatedWork W2399715051 @default.
- W272115035 hasRelatedWork W2420696719 @default.
- W272115035 hasRelatedWork W3146699217 @default.
- W272115035 hasRelatedWork W4240836450 @default.
- W272115035 hasRelatedWork W4244403799 @default.
- W272115035 hasRelatedWork W972261972 @default.
- W272115035 hasVolume "186" @default.
- W272115035 isParatext "false" @default.
- W272115035 isRetracted "false" @default.
- W272115035 magId "272115035" @default.
- W272115035 workType "article" @default.