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• W272119370 endingPage "328" @default.
• W272119370 startingPage "315" @default.
• W272119370 abstract "The synthesis of specific proteins in the terminal adrenergic neurons of rats and mice is regulated by the activity of the preganglionic cholinergic nerves and by the nerve growth factor (NGF) both during development and adult life. In adult animals an increased activity of the preganglionic cholinergic fibers results in an enhanced synthesis of tyrosine hydroxylase and dopamine-β-hydroxylase, whereas dopa decarboxylase, the third enzyme involved in the synthesis of norepinephrine, remains unchanged. There is good evidence that acetylcholine is the first messenger in this trans-synaptic induction of specific enzymes, whereas the identity of the second messenger, particularly the possible involvement of cyclic nucleotides, is not yet settled. NGF, a protein isolated from mouse salivary glands, produces in the sympathetic ganglia of newborn animals changes in the enzyme pattern which are very similar to those resulting from increased preganglionic activity in adult animals. For normal postnatal development of the terminal adrenergic neurons both the activity of the preganglionic cholinergic fibers and NGF is necessary. NGF is also essential for the maintenance of normal function in adult animals. This can be deduced from the fact that the decay of plasma NGF after removal of the submaxillary glands in mice is followed by a gradual decrease of all the enzymes involved in norepinephrine synthesis in superior cervical and stellate ganglia. However, although the submaxillary glands seem to be the major site of synthesis of NGF under normal physiological conditions, other tissues are also able to synthesize NGF and to take over this function of the salivary glands. Furthermore, it has been shown that NGF is accumulated in sympathetic ganglia and that it is transported retrogradely from the nerve terminals to the cell body. Whether NGF produces its effects essentially by this latter mechanism or rather by a direct action on the cell body, remains to be established." @default.
• W272119370 created "2016-06-24" @default.
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• W272119370 date "1974-01-01" @default.
• W272119370 modified "2023-09-25" @default.
• W272119370 title "REGULATION OF ENZYME SYNTHESIS BY NEURONAL ACTIVITY AND BY NERVE GROWTH FACTOR" @default.
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• W272119370 doi "https://doi.org/10.1016/b978-0-08-017917-9.50030-5" @default.
• W272119370 hasPublicationYear "1974" @default.
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