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- W2722722487 abstract "Structured Abstract Objectives To investigate and discuss the effects of cocoa on orofacial pain. Setting and Sample Population The Department of Orthodontics at the University of Florida ( UF ). Male and female hairless rats (N=20/group) were tested. Materials and Methods Rats were tested using the Orofacial Pain Assessment Device ( OPAD ) before and after changing their food from the standard chow to a cocoa‐enriched or control‐equivalent diet. Results Male rats fed the cocoa diet had a significantly higher operant pain index when tested at 37°C as compared to control diet‐fed animals. Female rats on the cocoa diet had a significantly higher pain index when tested at 18°C and 44°C, as compared to animals fed the control diet. Capsaicin‐induced pain was inhibited, with cocoa‐diet male rats having a significantly higher pain index than control‐diet male rats and cocoa‐diet female rats at both 37°C and 44°C. Cocoa‐diet female rats had a significantly higher pain index at 44°C than control‐diet females. Mechanical sensitivity was affected following capsaicin cream, with a significantly decreased tolerated bottle distance in both cocoa‐ and control‐diet animals, but there was no difference between cocoa‐ and control‐diet groups. Conclusion Using the OPAD operant system, we demonstrated that a diet rich in cocoa was effective in inhibiting neurogenic inflammatory pain in rats. This has implications for the use of novel alternative therapies such as diet modification for pain control." @default.
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- W2722722487 date "2017-06-01" @default.
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- W2722722487 title "Effects of cocoa-enriched diet on orofacial pain in a murine model" @default.
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- W2722722487 doi "https://doi.org/10.1111/ocr.12149" @default.
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