Matches in SemOpenAlex for { <https://semopenalex.org/work/W27238432> ?p ?o ?g. }
- W27238432 endingPage "2743" @default.
- W27238432 startingPage "2735" @default.
- W27238432 abstract "Achieving early, complete, and sustained reperfusion after acute myocardial infarction does not occur in approximately 50% of patients, even with the most potent established thrombolytic therapy. Bleeding is observed with increased concentrations of thrombolytics as well as with adjunctive antithrombotic and antiplatelet agents. A novel approach to enhance thrombolytic therapy is to inhibit the activated form of thrombin-activatable fibrinolysis inhibitor (TAFI), which attenuates fibrinolysis in clots formed from human plasma. Identification of TAFI in rabbit plasma facilitated the development of a rabbit arterial thrombolysis model to compare the thrombolytic efficacy of tissue-plasminogen activator (tPA) alone or with an inhibitor, isolated from the potato tuber (PTI), of activated TAFI (TAFIa). Efficacy was assessed by determining the time to patency, the time the vessel remained patent, the maximal blood flow achieved during therapy, the percentage of the original thrombus, which lysed, the percentage change in clot weight, the net clot accreted, and the release of radioactive fibrin degradation products into the circulation. The results indicate that coadministration of PTI and tPA significantly improved tPA-induced thrombolysis without adversely affecting blood pressure, activated partial thromboplastin time, thrombin clotting time, fibrinogen, or -2-antiplasmin concentrations. The data indicate that inhibitors of TAFIa may comprise novel and very effective adjuncts to tPA and improve thrombolytic therapy to achieve both clot lysis and vessel patency." @default.
- W27238432 created "2016-06-24" @default.
- W27238432 creator A5002697044 @default.
- W27238432 creator A5032829426 @default.
- W27238432 creator A5051645334 @default.
- W27238432 date "1999-10-15" @default.
- W27238432 modified "2023-10-13" @default.
- W27238432 title "A Novel Approach to Arterial Thrombolysis" @default.
- W27238432 cites W1264942373 @default.
- W27238432 cites W1483922672 @default.
- W27238432 cites W1486830389 @default.
- W27238432 cites W1494222932 @default.
- W27238432 cites W1514226843 @default.
- W27238432 cites W1521574535 @default.
- W27238432 cites W1566240917 @default.
- W27238432 cites W1569381450 @default.
- W27238432 cites W1584865207 @default.
- W27238432 cites W1623259890 @default.
- W27238432 cites W1757375456 @default.
- W27238432 cites W1969065690 @default.
- W27238432 cites W1972083038 @default.
- W27238432 cites W1977452105 @default.
- W27238432 cites W1977497608 @default.
- W27238432 cites W1978039741 @default.
- W27238432 cites W1983126671 @default.
- W27238432 cites W2001285874 @default.
- W27238432 cites W2001732339 @default.
- W27238432 cites W2001924510 @default.
- W27238432 cites W2002092614 @default.
- W27238432 cites W2005134321 @default.
- W27238432 cites W2025410012 @default.
- W27238432 cites W2039130243 @default.
- W27238432 cites W2050736179 @default.
- W27238432 cites W2066822578 @default.
- W27238432 cites W2072856207 @default.
- W27238432 cites W2073273161 @default.
- W27238432 cites W2075319601 @default.
- W27238432 cites W2099363777 @default.
- W27238432 cites W2101108802 @default.
- W27238432 cites W2105699409 @default.
- W27238432 cites W2112704241 @default.
- W27238432 cites W2156091573 @default.
- W27238432 cites W2333330110 @default.
- W27238432 cites W2336267479 @default.
- W27238432 cites W2408793120 @default.
- W27238432 cites W2409296984 @default.
- W27238432 cites W2477808709 @default.
- W27238432 cites W2589416296 @default.
- W27238432 cites W3025057188 @default.
- W27238432 cites W4231431115 @default.
- W27238432 cites W4241659925 @default.
- W27238432 cites W4242128015 @default.
- W27238432 cites W4254330207 @default.
- W27238432 cites W4256373284 @default.
- W27238432 cites W55986542 @default.
- W27238432 doi "https://doi.org/10.1182/blood.v94.8.2735.420k30_2735_2743" @default.
- W27238432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10515877" @default.
- W27238432 hasPublicationYear "1999" @default.
- W27238432 type Work @default.
- W27238432 sameAs 27238432 @default.
- W27238432 citedByCount "134" @default.
- W27238432 countsByYear W272384322012 @default.
- W27238432 countsByYear W272384322013 @default.
- W27238432 countsByYear W272384322014 @default.
- W27238432 countsByYear W272384322015 @default.
- W27238432 countsByYear W272384322016 @default.
- W27238432 countsByYear W272384322018 @default.
- W27238432 countsByYear W272384322020 @default.
- W27238432 countsByYear W272384322021 @default.
- W27238432 countsByYear W272384322022 @default.
- W27238432 crossrefType "journal-article" @default.
- W27238432 hasAuthorship W27238432A5002697044 @default.
- W27238432 hasAuthorship W27238432A5032829426 @default.
- W27238432 hasAuthorship W27238432A5051645334 @default.
- W27238432 hasConcept C126322002 @default.
- W27238432 hasConcept C164705383 @default.
- W27238432 hasConcept C203014093 @default.
- W27238432 hasConcept C2776572282 @default.
- W27238432 hasConcept C2776825266 @default.
- W27238432 hasConcept C2777015399 @default.
- W27238432 hasConcept C2777292125 @default.
- W27238432 hasConcept C2778261982 @default.
- W27238432 hasConcept C2778382381 @default.
- W27238432 hasConcept C2779036427 @default.
- W27238432 hasConcept C2779581417 @default.
- W27238432 hasConcept C2781362458 @default.
- W27238432 hasConcept C2909817843 @default.
- W27238432 hasConcept C500558357 @default.
- W27238432 hasConcept C54173615 @default.
- W27238432 hasConcept C71924100 @default.
- W27238432 hasConcept C89560881 @default.
- W27238432 hasConcept C98274493 @default.
- W27238432 hasConceptScore W27238432C126322002 @default.
- W27238432 hasConceptScore W27238432C164705383 @default.
- W27238432 hasConceptScore W27238432C203014093 @default.
- W27238432 hasConceptScore W27238432C2776572282 @default.
- W27238432 hasConceptScore W27238432C2776825266 @default.
- W27238432 hasConceptScore W27238432C2777015399 @default.