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- W2724113414 endingPage "439" @default.
- W2724113414 startingPage "423" @default.
- W2724113414 abstract "One of the most interesting but tenebrous parts of the bipolar disorder (BD) story is the switch between (hypo)mania and depression, which can give bipolar patients a thrilling, but somewhat perilous, ‘ride’. Numerous studies have pointed out that there are some recognizable differences (either state-dependent or state-independent) in several brain regions of people with BD, including components of the brain’s reward system. Understanding the underpinning mechanisms of high and low mood statuses in BD has potential, not only for the development of highly specific and selective pharmaceutical agents, but also for better treatment approaches and psychological interventions to manage BD and, thus, give patients a safer ride. Herein, we review evidence that supports involvement of the reward system in the pathophysiology of mood swings, with the main focus on the mesocorticolimbic dopaminergic neural circuitry. Principally using findings from neuroimaging studies, we aim to signpost readers as to how mood alterations may affect different areas of the reward system and how antipsychotic drugs can influence the activity of these brain areas. Finally, we critically evaluate the hypothesis that the mesocorticolimbic dopamine reward system may act as a functional rheostat for different mood states." @default.
- W2724113414 created "2017-07-14" @default.
- W2724113414 creator A5006902202 @default.
- W2724113414 creator A5017186135 @default.
- W2724113414 creator A5024648522 @default.
- W2724113414 creator A5027302697 @default.
- W2724113414 creator A5029909665 @default.
- W2724113414 creator A5041519854 @default.
- W2724113414 creator A5088194688 @default.
- W2724113414 date "2017-06-14" @default.
- W2724113414 modified "2023-10-16" @default.
- W2724113414 title "A Brain on a Roller Coaster: Can the Dopamine Reward System Act as a Protagonist to Subdue the Ups and Downs of Bipolar Disorder?" @default.
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