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- W2724312978 abstract "Tumorigenesis is a multi-step and complex process with multi-factors involved. Deregulated oncogenes and tumor suppressor genes (TSGs) induced by genetic and epigenetic factors are considered as the driving force in the development and progression of cancer. Besides, microRNAs (miRNAs) act vital roles in tumorigenesis through regulating some oncogenes and TSGs. Interestingly, miRNAs are also regulated by oncogenes and TSGs. Considering the entangled regulation, here we propose a new insight into these regulation relationships in cancer: oncogene-miRNA-TSG network, which further emphasizes roles of miRNA, as well as highlights the network regulation among oncogene, miRNA, and TSG during tumorigenesis. The oncogene-miRNA-TSG network demonstrates that oncogenes and TSGs not only show functional synergy, but also there are regulatory relationships among oncogenes and TSGs during tumorigenesis, which could be mediated by miRNAs. In view of the oncogene-miRNA-TSG network involved in many oncogenes, miRNAs, and TSGs, as well as occurring in various tumor types, the anomaly of this network may be a common event in cancers and participates in tumorigenesis. This hypothesis broadens horizons of molecular mechanisms underlying tumorigenesis, and may provide a new promising venue for the prediction, diagnosis, and even therapy of cancer." @default.
- W2724312978 created "2017-07-14" @default.
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- W2724312978 date "2017-07-07" @default.
- W2724312978 modified "2023-10-15" @default.
- W2724312978 title "New Insight into microRNA Functions in Cancer: Oncogene–microRNA–Tumor Suppressor Gene Network" @default.
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- W2724312978 cites W1882520474 @default.
- W2724312978 cites W1969671165 @default.
- W2724312978 cites W1972892962 @default.
- W2724312978 cites W1974254202 @default.
- W2724312978 cites W1976888700 @default.
- W2724312978 cites W1983991097 @default.
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- W2724312978 cites W2005109475 @default.
- W2724312978 cites W2007935491 @default.
- W2724312978 cites W2012654383 @default.
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- W2724312978 cites W2019078072 @default.
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- W2724312978 cites W2022495797 @default.
- W2724312978 cites W2023623233 @default.
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- W2724312978 cites W2038167014 @default.
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- W2724312978 doi "https://doi.org/10.3389/fmolb.2017.00046" @default.
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