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• W2724409250 abstract "In light of technical advancements supporting exploration of MR signals other than 1H, sodium (23Na) has received attention as a marker of ionic homeostasis and cell viability. Here, we evaluate for the first time the possibility that 23Na-MRI is sensitive to pathological processes occurring in human epilepsy. A normative sample of 27 controls was used to normalize regions of interest (ROIs) from 1424 unique brain locales on quantitative 23Na-MRI and high-resolution 1H-MPRAGE images. ROIs were based on intracerebral electrodes in ten patients undergoing epileptic network mapping. The stereo-EEG gold standard was used to define regions as belonging to primarily epileptogenic, secondarily irritative and to non-involved regions. Estimates of total sodium concentration (TSC) on 23Na-MRI and cerebrospinal fluid (CSF) on 1H imaging were extracted for each patient ROI, and normalized against the same region in controls. ROIs with disproportionate CSF contributions (ZCSF≥1.96) were excluded. TSC levels were found to be elevated in patients relative to controls except in one patient, who suffered non-convulsive seizures during the scan, in whom we found reduced TSC levels. In the remaining patients, an ANOVA (F1100= 12.37, p<0.0001) revealed a highly significant effect of clinically-defined zones (F1100= 11.13, p<0.0001), with higher normalized TSC in the epileptogenic zone relative to both secondarily irritative (F1100= 11, p=0.0009) and non-involved regions (F1100= 17.8, p<0.0001). We provide the first non-invasive, in vivo evidence of a chronic TSC elevation alongside ZCSF levels within the normative range, associated with the epileptogenic region even during the interictal period in human epilepsy, and the possibility of reduced TSC levels due to seizure. In line with modified homeostatic mechanisms in epilepsy – including altered mechanisms underlying ionic gating, clearance and exchange – we provide the first indication of 23Na-MRI as an assay of altered sodium concentrations occurring in epilepsy associated with the organization of clinically relevant divisions of pathological cortex." @default.
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• W2724409250 date "2017-08-01" @default.
• W2724409250 modified "2023-10-18" @default.
• W2724409250 title "Brain sodium MRI in human epilepsy: Disturbances of ionic homeostasis reflect the organization of pathological regions" @default.
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• W2724409250 cites W1915622992 @default.
• W2724409250 cites W1941985665 @default.
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• W2724409250 cites W1966748281 @default.
• W2724409250 cites W1967049569 @default.
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• W2724409250 cites W1973222984 @default.
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• W2724409250 cites W1978293111 @default.
• W2724409250 cites W1979787136 @default.
• W2724409250 cites W1982140245 @default.
• W2724409250 cites W1988198308 @default.
• W2724409250 cites W1994319185 @default.
• W2724409250 cites W2006115379 @default.
• W2724409250 cites W2009004471 @default.
• W2724409250 cites W2011436802 @default.
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• W2724409250 cites W2024133952 @default.
• W2724409250 cites W2027537355 @default.
• W2724409250 cites W2035348090 @default.
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• W2724409250 cites W2064425045 @default.
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• W2724409250 doi "https://doi.org/10.1016/j.neuroimage.2017.06.011" @default.
• W2724409250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28602596" @default.
• W2724409250 hasPublicationYear "2017" @default.
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