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• W2724413194 abstract "Abstract Synthetic biology applied to industrial biotechnology is transforming the way we produce chemicals. However, despite advances in the scale and scope of metabolic engineering, the bioproduction process still remains costly. In order to expand the chemical repertoire for the production of next generation compounds, a major engineering biology effort is required in the development of novel design tools that target chemical diversity through rapid and predictable protocols. Addressing that goal involves retrosynthesis approaches that explore the chemical biosynthetic space. However, the complexity associated with the large combinatorial retrosynthesis design space has often been recognized as the main challenge hindering the approach. Here, we provide RetroPath2.0, an automated open source workflow for retrosynthesis based on generalized reaction rules that perform the retrosynthesis search from chassis to target through an efficient and well-controlled protocol. Its easiness of use and the versatility of its applications make of this tool a valuable addition into the biological engineer bench desk. We show through several examples the application of the workflow to biotechnological relevant problems, including the identification of alternative biosynthetic routes through enzyme promiscuity; or the development of biosensors. We demonstrate in that way the ability of the workflow to streamline retrosynthesis pathway design and its major role in reshaping the design, build, test and learn pipeline by driving the process toward the objective of optimizing bioproduction. The RetroPath2.0 workflow is built using tools developed by the bioinformatics and cheminformatics community, because it is open source we anticipate community contributions will likely expand further the features of the workflow. Highlights State-of-the-art Computer-Aided Design retrosynthesis solutions lack open source and ease of use We propose RetroPath2.0 a modular and open-source workflow to perform retrosynthesis RetroPath2.0 computes reaction network between Source and Sink sets of compounds RetroPath2.0 is distributed as a KNIME workflow for desktop computers RetroPath2.0 is ready-for-use and distributed with reaction rules Funding This work was supported by the French National Research Agency [ANR-15-CE1-0008], the Biotechnology and Biological Sciences Research Council, Centre for synthetic biology of fine and speciality chemicals [BB/M017702/1]; Synthetic Biology Applications for Protective Materials [EP/N025504/1], and GIP Genopole." @default.
• W2724413194 created "2017-07-14" @default.
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• W2724413194 date "2017-06-29" @default.
• W2724413194 modified "2023-09-24" @default.
• W2724413194 title "RetroPath2.0: a retrosynthesis workflow for metabolic engineers" @default.
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• W2724413194 cites W1577825084 @default.
• W2724413194 cites W1758395617 @default.
• W2724413194 cites W1835740130 @default.
• W2724413194 cites W1934481644 @default.
• W2724413194 cites W1952732684 @default.
• W2724413194 cites W1964232618 @default.
• W2724413194 cites W1964572291 @default.
• W2724413194 cites W1966850681 @default.
• W2724413194 cites W1967394343 @default.
• W2724413194 cites W1969389753 @default.
• W2724413194 cites W1973166400 @default.
• W2724413194 cites W1976668480 @default.
• W2724413194 cites W1977550796 @default.
• W2724413194 cites W1990226486 @default.
• W2724413194 cites W1995370815 @default.
• W2724413194 cites W1996830618 @default.
• W2724413194 cites W1997996256 @default.
• W2724413194 cites W2020996919 @default.
• W2724413194 cites W2021099440 @default.
• W2724413194 cites W2022664874 @default.
• W2724413194 cites W2024038403 @default.
• W2724413194 cites W2025891673 @default.
• W2724413194 cites W2027486231 @default.
• W2724413194 cites W2030555543 @default.
• W2724413194 cites W2045009580 @default.
• W2724413194 cites W2050423447 @default.
• W2724413194 cites W2062761417 @default.
• W2724413194 cites W2067156145 @default.
• W2724413194 cites W2068855150 @default.
• W2724413194 cites W2084012522 @default.
• W2724413194 cites W2089121522 @default.
• W2724413194 cites W2094812249 @default.
• W2724413194 cites W2103708054 @default.
• W2724413194 cites W2104619491 @default.
• W2724413194 cites W2104950117 @default.
• W2724413194 cites W2108595206 @default.
• W2724413194 cites W2113531097 @default.
• W2724413194 cites W2124737787 @default.
• W2724413194 cites W2128312954 @default.
• W2724413194 cites W2128479500 @default.
• W2724413194 cites W2131504364 @default.
• W2724413194 cites W2132468877 @default.
• W2724413194 cites W2133090606 @default.
• W2724413194 cites W2148842928 @default.
• W2724413194 cites W2149981735 @default.
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• W2724413194 cites W2156125289 @default.
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• W2724413194 cites W2165612309 @default.
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• W2724413194 cites W2335566724 @default.
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• W2724413194 doi "https://doi.org/10.1101/141721" @default.
• W2724413194 hasPublicationYear "2017" @default.
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