FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2724488549> ?p ?o ?g. }

• W2724488549 endingPage "17" @default.
• W2724488549 startingPage "1" @default.
• W2724488549 abstract "Cell migration and molecular mechanisms during healing of damaged vascular or muscle tissues are emerging fields of interest worldwide. The study herein focuses on evaluating the role of allogenic adipose-derived mesenchymal stem cells (ADMSCs) in restoring damaged tissues. Using a hindlimb ischemic mouse model, ADMSC-mediated induction of cell migration and gene expression related to myocyte regeneration and angiogenesis were evaluated. ADMSCs were labeled with GFP (ADMSC-GFP). The proximal end of the femoral blood vessel of mice (over 6 months of age) are ligated at two positions then cut between the two ties. Hindlimb ischemic mice were randomly divided into two groups: Group I (n = 30) which was injected with PBS (100 μL) and Group II (n = 30) which was transplanted with ADMSC-GFP (106 cells/100 μL PBS) at the rectus femoris muscle. The migration of ADMSC-GFP in hindlimb was analyzed by UV-Vis system. The expression of genes related to angiogenesis and muscle tissue repair was quantified by real-time RT-PCR. The results showed that ADMSCs existed in the grafted hindlimb for 7 days. Grafted cells migrated to other damaged areas such as thigh and heel. In both groups the ischemic hindlimb showed an increased expression of several angiogenic genes, including Flt-1, Flk-1, and Ang-2. In particular, the expression of Ang-2 and myogenic-related gene MyoD was significantly increased in the ADMSC-treated group compared to the PBS-treated (control) group; the expression increased at day 28 compared to day 3. The other factors, such as VE-Cadherin, HGF, CD31, Myf5, and TGF-β, were also more highly expressed in the ADMSC-treated group than in the control group. Thus, grafted ADMSCs were able to migrate to other areas in the injured hindlimb, persist for approximately 7 days, and have a significantly positive impact on stimulating expression of myogenic- and angiogenesis-related genes." @default.
• W2724488549 created "2017-07-14" @default.
• W2724488549 creator A5001112880 @default.
• W2724488549 creator A5038895668 @default.
• W2724488549 creator A5041587814 @default.
• W2724488549 creator A5050866789 @default.
• W2724488549 creator A5085026603 @default.
• W2724488549 creator A5089073230 @default.
• W2724488549 date "2017-01-01" @default.
• W2724488549 modified "2023-09-27" @default.
• W2724488549 title "Allogeneic Adipose-Derived Mesenchymal Stem Cell Transplantation Enhances the Expression of Angiogenic Factors in a Mouse Acute Hindlimb Ischemic Model" @default.
• W2724488549 cites W1536518696 @default.
• W2724488549 cites W1540436551 @default.
• W2724488549 cites W1587020653 @default.
• W2724488549 cites W1624599859 @default.
• W2724488549 cites W1766826856 @default.
• W2724488549 cites W1965727192 @default.
• W2724488549 cites W1973918329 @default.
• W2724488549 cites W1977611517 @default.
• W2724488549 cites W1983493560 @default.
• W2724488549 cites W1984513282 @default.
• W2724488549 cites W1990027846 @default.
• W2724488549 cites W1991889240 @default.
• W2724488549 cites W1991988594 @default.
• W2724488549 cites W1999579644 @default.
• W2724488549 cites W2000292756 @default.
• W2724488549 cites W2001500938 @default.
• W2724488549 cites W2002218662 @default.
• W2724488549 cites W2020968632 @default.
• W2724488549 cites W2027222801 @default.
• W2724488549 cites W2030620101 @default.
• W2724488549 cites W2032347891 @default.
• W2724488549 cites W2036437770 @default.
• W2724488549 cites W2042896736 @default.
• W2724488549 cites W2053551217 @default.
• W2724488549 cites W2058239698 @default.
• W2724488549 cites W2059567868 @default.
• W2724488549 cites W2068642718 @default.
• W2724488549 cites W2068754779 @default.
• W2724488549 cites W2073621056 @default.
• W2724488549 cites W2076374640 @default.
• W2724488549 cites W2079691345 @default.
• W2724488549 cites W2081590172 @default.
• W2724488549 cites W2091395040 @default.
• W2724488549 cites W2092074451 @default.
• W2724488549 cites W2098728140 @default.
• W2724488549 cites W2113032212 @default.
• W2724488549 cites W2118437843 @default.
• W2724488549 cites W2121311096 @default.
• W2724488549 cites W2125914414 @default.
• W2724488549 cites W2127878160 @default.
• W2724488549 cites W2129752592 @default.
• W2724488549 cites W2130356372 @default.
• W2724488549 cites W2137022580 @default.
• W2724488549 cites W2138936912 @default.
• W2724488549 cites W2139971123 @default.
• W2724488549 cites W2141571435 @default.
• W2724488549 cites W2147135453 @default.
• W2724488549 cites W2149162919 @default.
• W2724488549 cites W2149996379 @default.
• W2724488549 cites W2154935039 @default.
• W2724488549 cites W2167351436 @default.
• W2724488549 cites W2172253185 @default.
• W2724488549 cites W2273945185 @default.
• W2724488549 cites W2293815148 @default.
• W2724488549 cites W2405091380 @default.
• W2724488549 cites W2414934403 @default.
• W2724488549 cites W578300573 @default.
• W2724488549 doi "https://doi.org/10.1007/5584_2017_63" @default.
• W2724488549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28687961" @default.
• W2724488549 hasPublicationYear "2017" @default.
• W2724488549 type Work @default.
• W2724488549 sameAs 2724488549 @default.
• W2724488549 citedByCount "3" @default.
• W2724488549 countsByYear W27244885492017 @default.
• W2724488549 countsByYear W27244885492018 @default.
• W2724488549 countsByYear W27244885492022 @default.
• W2724488549 crossrefType "book-chapter" @default.
• W2724488549 hasAuthorship W2724488549A5001112880 @default.
• W2724488549 hasAuthorship W2724488549A5038895668 @default.
• W2724488549 hasAuthorship W2724488549A5041587814 @default.
• W2724488549 hasAuthorship W2724488549A5050866789 @default.
• W2724488549 hasAuthorship W2724488549A5085026603 @default.
• W2724488549 hasAuthorship W2724488549A5089073230 @default.
• W2724488549 hasConcept C105702510 @default.
• W2724488549 hasConcept C126322002 @default.
• W2724488549 hasConcept C134018914 @default.
• W2724488549 hasConcept C142724271 @default.
• W2724488549 hasConcept C16685009 @default.
• W2724488549 hasConcept C171089720 @default.
• W2724488549 hasConcept C198826908 @default.
• W2724488549 hasConcept C2778106681 @default.
• W2724488549 hasConcept C2779959927 @default.
• W2724488549 hasConcept C2780394083 @default.
• W2724488549 hasConcept C28328180 @default.
• W2724488549 hasConcept C2911091166 @default.
• W2724488549 hasConcept C3763915 @default.
• W2724488549 hasConcept C502942594 @default.

• next