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- W2724676801 abstract "Introduction: Transrectal ultrasound (TRUS) is a cost-effective test for prediction of rectal cancer. However, whether the accuracy of TRUS is correlated with tumor location remains obscured. This study is designed to explore their potential relationship and confirm an optimal tumor location of using this test for rectal cancer staging. Methods: From 2005 and 2011, rectal cancer patients with TRUS data were retrospectively reviewed. Patients were divided into five groups according to tumor-involved rectal segmentation: SEG I 1-3cm, II 3-6cm, III 6-9cm, IV 9-12cm, and V 12-16cm. The accuracy and long-term outcomes of tumor staging were compared between ultrasonic and histological staging. Results: In all, 219 patients were included, with 55 (25.1%) in SEG I, 123 (56.2%) in SEG II, 32 (14.6%) in SEG III, 4 (1.8%) in SEG IV and 5 (2.3%) in SEG V. The overall accuracy of TRUS staging was remarkably superior to clinical staging (64.8% vs. 34.7%, P < 0.001), with 70.3% and 82.2% for ultrasonic T and N stage respectively. The overall accuracy of TRUS reached the peak when tumors located in the second rectal segment. Besides, overall 5-year survival had no significant difference between TRUS and pathology staging. A cox regression analysis indicated that CEA level and tumor location were risk factors of inaccurate ultrasound staging. Conclusion: TRUS is a valuable examination for prediction of rectal cancer following neoadjuvant therapy. The optimal application of TRUS would be most accurate when rectal tumors are 3-6 cm distant to anal verge." @default.
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- W2724676801 date "2017-06-01" @default.
- W2724676801 modified "2023-10-17" @default.
- W2724676801 title "The optimal application of transrectal ultrasound in staging of rectal cancer following neoadjuvant therapy: A pragmatic study for accuracy investigation" @default.
- W2724676801 doi "https://doi.org/10.1093/annonc/mdx261.361" @default.
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