FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2724814774> ?p ?o ?g. }

• W2724814774 endingPage "1731" @default.
• W2724814774 startingPage "1726" @default.
• W2724814774 abstract "The Retinoblastoma (RB) tumor suppressor regulates G1 /S transition during cell cycle progression by modulating the activity of E2F transcription factors. The RB pathway plays a central role in the suppression of most cancers, and RB mutation was initially discovered by virtue of its role in tumor initiation. However, as cancer genome sequencing has evolved to profile more advanced and treatment-resistant cancers, it has become increasingly clear that, in the majority of cancers, somatic RB inactivation occurs during tumor progression. Furthermore, despite the presence of deregulation of cell cycle control due to an INK4A deletion, additional CCND amplification and/or other mutations in the RB pathway, mutation or deletion of the RB gene is often observed during cancer progression. Of note, RB inactivation during cancer progression not only facilitates G1 /S transition but also enhances some characteristics of malignancy, including altered drug sensitivity and a return to the undifferentiated state. Recently, we reported that RB inactivation enhances pro-inflammatory signaling through stimulation of the interleukin-6/STAT3 pathway, which directly promotes various malignant features of cancer cells. In this review, we highlight the consequences of RB inactivation during cancer progression, and discuss the biological and pathological significance of the interaction between RB and pro-inflammatory signaling." @default.
• W2724814774 created "2017-07-14" @default.
• W2724814774 creator A5049376792 @default.
• W2724814774 creator A5057597665 @default.
• W2724814774 date "2017-07-29" @default.
• W2724814774 modified "2023-10-13" @default.
• W2724814774 title "Intersection of retinoblastoma tumor suppressor function, stem cells, metabolism, and inflammation" @default.
• W2724814774 cites W115026875 @default.
• W2724814774 cites W1546551973 @default.
• W2724814774 cites W1561850791 @default.
• W2724814774 cites W1970269422 @default.
• W2724814774 cites W1974145397 @default.
• W2724814774 cites W1983827654 @default.
• W2724814774 cites W1983973679 @default.
• W2724814774 cites W1986418246 @default.
• W2724814774 cites W1987283660 @default.
• W2724814774 cites W1990376085 @default.
• W2724814774 cites W1991192947 @default.
• W2724814774 cites W1993624611 @default.
• W2724814774 cites W1995860724 @default.
• W2724814774 cites W2001004678 @default.
• W2724814774 cites W2006247279 @default.
• W2724814774 cites W2009719239 @default.
• W2724814774 cites W2018234708 @default.
• W2724814774 cites W2021579554 @default.
• W2724814774 cites W2023300506 @default.
• W2724814774 cites W2028328585 @default.
• W2724814774 cites W2029483334 @default.
• W2724814774 cites W2035114699 @default.
• W2724814774 cites W2037338364 @default.
• W2724814774 cites W2037387159 @default.
• W2724814774 cites W2037811991 @default.
• W2724814774 cites W2040267618 @default.
• W2724814774 cites W2041399911 @default.
• W2724814774 cites W2051445779 @default.
• W2724814774 cites W2052540412 @default.
• W2724814774 cites W2053047691 @default.
• W2724814774 cites W2055395862 @default.
• W2724814774 cites W2056633943 @default.
• W2724814774 cites W2060185596 @default.
• W2724814774 cites W2061780077 @default.
• W2724814774 cites W2064484411 @default.
• W2724814774 cites W2071333117 @default.
• W2724814774 cites W2076392163 @default.
• W2724814774 cites W2079941948 @default.
• W2724814774 cites W2080157553 @default.
• W2724814774 cites W2094295288 @default.
• W2724814774 cites W2095320189 @default.
• W2724814774 cites W2104775085 @default.
• W2724814774 cites W2107804869 @default.
• W2724814774 cites W2108643617 @default.
• W2724814774 cites W2114817620 @default.
• W2724814774 cites W2115585914 @default.
• W2724814774 cites W2117210015 @default.
• W2724814774 cites W2117692326 @default.
• W2724814774 cites W2119828139 @default.
• W2724814774 cites W2122846804 @default.
• W2724814774 cites W2123611122 @default.
• W2724814774 cites W2131029596 @default.
• W2724814774 cites W2136792748 @default.
• W2724814774 cites W2140554630 @default.
• W2724814774 cites W2140618607 @default.
• W2724814774 cites W2143404258 @default.
• W2724814774 cites W214449776 @default.
• W2724814774 cites W2146731647 @default.
• W2724814774 cites W2149852478 @default.
• W2724814774 cites W2151037856 @default.
• W2724814774 cites W2153086428 @default.
• W2724814774 cites W2159058669 @default.
• W2724814774 cites W2160371778 @default.
• W2724814774 cites W2160827956 @default.
• W2724814774 cites W2162627731 @default.
• W2724814774 cites W2165860917 @default.
• W2724814774 cites W2165868533 @default.
• W2724814774 cites W2167344472 @default.
• W2724814774 cites W2170550202 @default.
• W2724814774 cites W2188903324 @default.
• W2724814774 cites W2340925531 @default.
• W2724814774 cites W2343623791 @default.
• W2724814774 cites W2397317955 @default.
• W2724814774 cites W2471978271 @default.
• W2724814774 cites W2514862430 @default.
• W2724814774 cites W2552764510 @default.
• W2724814774 cites W2567986926 @default.
• W2724814774 cites W2571250257 @default.
• W2724814774 cites W2575938490 @default.
• W2724814774 cites W2612207404 @default.
• W2724814774 doi "https://doi.org/10.1111/cas.13312" @default.
• W2724814774 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5581511" @default.
• W2724814774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28865172" @default.
• W2724814774 hasPublicationYear "2017" @default.
• W2724814774 type Work @default.
• W2724814774 sameAs 2724814774 @default.
• W2724814774 citedByCount "30" @default.
• W2724814774 countsByYear W27248147742018 @default.
• W2724814774 countsByYear W27248147742019 @default.
• W2724814774 countsByYear W27248147742020 @default.
• W2724814774 countsByYear W27248147742021 @default.

• next