Matches in SemOpenAlex for { <https://semopenalex.org/work/W2725123154> ?p ?o ?g. }
- W2725123154 endingPage "34" @default.
- W2725123154 startingPage "17" @default.
- W2725123154 abstract "The cardiac myocyte differs strikingly from the specialized cells of the immune system, which has two different responses to invading organisms and tissue damage. Adaptive or acquired immunity generates highly specific antibodies in response to threats and is an essential component of immunity; however, adaptive immunity can take 4-7 days to mobilize, and a more primitive response, innate immunity, fills the gap. Innate immunity is expressed in complex and in primitive life forms. Specialized receptors, Toll-like receptors (TLRs), which are widely distributed throughout different tissues recognize danger signals and rapidly respond with the release of noxious substances, such as TNFα. The problem is that many endogenous molecules have been found to act as ligands for specific TLRs, and when these molecules are released into the extracellular environment, they can cause problems by activating innate immunity and an inflammatory response. In cardiac myocytes heat shock protein (HSP)60 can activate TLR4, as can HMGB1, and this type of response can amplify the response to ischemia/reperfusion leading to increased cell and tissue injury. Activation of TLRs can potentially amplify chronic, inflammatory diseases, such as ischemic heart failure. Thus, it is important to understand the regulation of the TLRs and their downstream effects. This chapter will focus on the TLRs and cardiac myocytes." @default.
- W2725123154 created "2017-07-14" @default.
- W2725123154 creator A5091215873 @default.
- W2725123154 date "2017-01-01" @default.
- W2725123154 modified "2023-09-23" @default.
- W2725123154 title "Paying for the Tolls: The High Cost of the Innate Immune System for the Cardiac Myocyte" @default.
- W2725123154 cites W1514540900 @default.
- W2725123154 cites W1519633296 @default.
- W2725123154 cites W1534378060 @default.
- W2725123154 cites W1584629476 @default.
- W2725123154 cites W1591714343 @default.
- W2725123154 cites W1901873593 @default.
- W2725123154 cites W1946644601 @default.
- W2725123154 cites W1952548524 @default.
- W2725123154 cites W1964224666 @default.
- W2725123154 cites W1964567745 @default.
- W2725123154 cites W1965656662 @default.
- W2725123154 cites W1968064845 @default.
- W2725123154 cites W1969072247 @default.
- W2725123154 cites W1972776583 @default.
- W2725123154 cites W1973659410 @default.
- W2725123154 cites W1975064192 @default.
- W2725123154 cites W1983430686 @default.
- W2725123154 cites W1983784806 @default.
- W2725123154 cites W1983838712 @default.
- W2725123154 cites W1984499400 @default.
- W2725123154 cites W1992038850 @default.
- W2725123154 cites W1994391392 @default.
- W2725123154 cites W1995951180 @default.
- W2725123154 cites W2004465286 @default.
- W2725123154 cites W2005570998 @default.
- W2725123154 cites W2009521410 @default.
- W2725123154 cites W2012738222 @default.
- W2725123154 cites W2014293957 @default.
- W2725123154 cites W2016834327 @default.
- W2725123154 cites W2016862474 @default.
- W2725123154 cites W2018482893 @default.
- W2725123154 cites W2018538582 @default.
- W2725123154 cites W2019219781 @default.
- W2725123154 cites W2019664188 @default.
- W2725123154 cites W2021736304 @default.
- W2725123154 cites W2025237130 @default.
- W2725123154 cites W2030237203 @default.
- W2725123154 cites W2030852470 @default.
- W2725123154 cites W2046030017 @default.
- W2725123154 cites W2048497142 @default.
- W2725123154 cites W2051982686 @default.
- W2725123154 cites W2052414686 @default.
- W2725123154 cites W2056917800 @default.
- W2725123154 cites W2067708969 @default.
- W2725123154 cites W2069809822 @default.
- W2725123154 cites W2069943469 @default.
- W2725123154 cites W2071613661 @default.
- W2725123154 cites W2073547744 @default.
- W2725123154 cites W2074994532 @default.
- W2725123154 cites W2075113278 @default.
- W2725123154 cites W2076080662 @default.
- W2725123154 cites W2076361525 @default.
- W2725123154 cites W2078125361 @default.
- W2725123154 cites W2079139546 @default.
- W2725123154 cites W2083553869 @default.
- W2725123154 cites W2083682196 @default.
- W2725123154 cites W2086280571 @default.
- W2725123154 cites W2087954426 @default.
- W2725123154 cites W2090018141 @default.
- W2725123154 cites W2094605832 @default.
- W2725123154 cites W2107112369 @default.
- W2725123154 cites W2112078889 @default.
- W2725123154 cites W2112877326 @default.
- W2725123154 cites W2114041096 @default.
- W2725123154 cites W2114737175 @default.
- W2725123154 cites W2120000102 @default.
- W2725123154 cites W2126829776 @default.
- W2725123154 cites W2129284626 @default.
- W2725123154 cites W2130668675 @default.
- W2725123154 cites W2131654346 @default.
- W2725123154 cites W2131750038 @default.
- W2725123154 cites W2133616332 @default.
- W2725123154 cites W2133864129 @default.
- W2725123154 cites W2139608042 @default.
- W2725123154 cites W2140375278 @default.
- W2725123154 cites W2140735579 @default.
- W2725123154 cites W2141123335 @default.
- W2725123154 cites W2142563401 @default.
- W2725123154 cites W2143797732 @default.
- W2725123154 cites W2145584783 @default.
- W2725123154 cites W2145655023 @default.
- W2725123154 cites W2146311014 @default.
- W2725123154 cites W2148579227 @default.
- W2725123154 cites W2148823498 @default.
- W2725123154 cites W2150164439 @default.
- W2725123154 cites W2152375607 @default.
- W2725123154 cites W2152936237 @default.
- W2725123154 cites W2155900510 @default.
- W2725123154 cites W2155906523 @default.
- W2725123154 cites W2155983915 @default.
- W2725123154 cites W2159176408 @default.
- W2725123154 cites W2160117562 @default.