Matches in SemOpenAlex for { <https://semopenalex.org/work/W2725149750> ?p ?o ?g. }
- W2725149750 endingPage "153" @default.
- W2725149750 startingPage "142" @default.
- W2725149750 abstract "Hand hygiene plays a key role in nosocomial infection prevention. To achieve users' adherence, products' dermal tolerance is essential. We aimed at making a comparative assessment of skin irritation and phototoxicity of the 3 alcohols commonly used in alcohol-based hand rubs (Ethanol, Propan-2-ol, Propan-1-ol) at 60, 70, 80 or 85% w/w in water or with co-formulates (hydrating, emollient and skin protective agents). In vitro validated OECD methods 439 and 432 were used. For irritation, EpiSkin™ Small Model was the chosen Reconstructed Human Epidermis (RhE). For phototoxicity, co-formulates alone or in mixture with and without alcohol were tested using BALB/c 3T3 cell cultures. Whilst Ethanol and Propan-2-ol could not be differentiated and displayed good skin tolerance profiles, Propan-1-ol based products lead to significant viability impairments of RhE at 60, 70 or 80% and at 60% in the presence of co-formulates. However, these results could not be reproduced in another RhE model. Taking also into account bibliographic data on Propan-1-ol, this suggests that our results are probably related to a lack of specificity of the used RhE. Therefore, it can be relevant in case of significant results to use two different RhE models before performing any classification and/or performing any complementary tests." @default.
- W2725149750 created "2017-07-14" @default.
- W2725149750 creator A5014172677 @default.
- W2725149750 creator A5021810471 @default.
- W2725149750 creator A5028183842 @default.
- W2725149750 creator A5036356187 @default.
- W2725149750 creator A5047194433 @default.
- W2725149750 creator A5058433885 @default.
- W2725149750 creator A5065939099 @default.
- W2725149750 creator A5070882100 @default.
- W2725149750 creator A5071565339 @default.
- W2725149750 creator A5086553434 @default.
- W2725149750 date "2017-10-01" @default.
- W2725149750 modified "2023-10-15" @default.
- W2725149750 title "Comparative assessment of local tolerance of alcohols commonly used in alcohol-based hand rubs for hand hygiene" @default.
- W2725149750 cites W1589383656 @default.
- W2725149750 cites W1972847800 @default.
- W2725149750 cites W1979285465 @default.
- W2725149750 cites W1984172495 @default.
- W2725149750 cites W1986329842 @default.
- W2725149750 cites W1986338215 @default.
- W2725149750 cites W1988381039 @default.
- W2725149750 cites W1997076516 @default.
- W2725149750 cites W2000574141 @default.
- W2725149750 cites W2005158694 @default.
- W2725149750 cites W2006192584 @default.
- W2725149750 cites W2007574050 @default.
- W2725149750 cites W2010458564 @default.
- W2725149750 cites W2015354506 @default.
- W2725149750 cites W2021117487 @default.
- W2725149750 cites W2023666079 @default.
- W2725149750 cites W2029961564 @default.
- W2725149750 cites W2034419363 @default.
- W2725149750 cites W2036193434 @default.
- W2725149750 cites W2039436358 @default.
- W2725149750 cites W2042751368 @default.
- W2725149750 cites W2051500003 @default.
- W2725149750 cites W2064007068 @default.
- W2725149750 cites W2064197516 @default.
- W2725149750 cites W2065402764 @default.
- W2725149750 cites W2080672598 @default.
- W2725149750 cites W2082846747 @default.
- W2725149750 cites W2083033154 @default.
- W2725149750 cites W2084701157 @default.
- W2725149750 cites W2084727466 @default.
- W2725149750 cites W2085580227 @default.
- W2725149750 cites W2090567977 @default.
- W2725149750 cites W2091680643 @default.
- W2725149750 cites W2091706087 @default.
- W2725149750 cites W2093487930 @default.
- W2725149750 cites W2095295524 @default.
- W2725149750 cites W2110920491 @default.
- W2725149750 cites W2115244264 @default.
- W2725149750 cites W2119360374 @default.
- W2725149750 cites W2133614210 @default.
- W2725149750 cites W2151532351 @default.
- W2725149750 cites W2169031041 @default.
- W2725149750 cites W2170139938 @default.
- W2725149750 cites W2234535559 @default.
- W2725149750 cites W2259737942 @default.
- W2725149750 cites W4230510444 @default.
- W2725149750 cites W4236555657 @default.
- W2725149750 cites W4243647053 @default.
- W2725149750 cites W61220348 @default.
- W2725149750 doi "https://doi.org/10.1016/j.tiv.2017.07.004" @default.
- W2725149750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28700953" @default.
- W2725149750 hasPublicationYear "2017" @default.
- W2725149750 type Work @default.
- W2725149750 sameAs 2725149750 @default.
- W2725149750 citedByCount "1" @default.
- W2725149750 countsByYear W27251497502021 @default.
- W2725149750 crossrefType "journal-article" @default.
- W2725149750 hasAuthorship W2725149750A5014172677 @default.
- W2725149750 hasAuthorship W2725149750A5021810471 @default.
- W2725149750 hasAuthorship W2725149750A5028183842 @default.
- W2725149750 hasAuthorship W2725149750A5036356187 @default.
- W2725149750 hasAuthorship W2725149750A5047194433 @default.
- W2725149750 hasAuthorship W2725149750A5058433885 @default.
- W2725149750 hasAuthorship W2725149750A5065939099 @default.
- W2725149750 hasAuthorship W2725149750A5070882100 @default.
- W2725149750 hasAuthorship W2725149750A5071565339 @default.
- W2725149750 hasAuthorship W2725149750A5086553434 @default.
- W2725149750 hasConcept C142724271 @default.
- W2725149750 hasConcept C16005928 @default.
- W2725149750 hasConcept C178790620 @default.
- W2725149750 hasConcept C185592680 @default.
- W2725149750 hasConcept C202751555 @default.
- W2725149750 hasConcept C203014093 @default.
- W2725149750 hasConcept C20639190 @default.
- W2725149750 hasConcept C2777063393 @default.
- W2725149750 hasConcept C2780161600 @default.
- W2725149750 hasConcept C2781066024 @default.
- W2725149750 hasConcept C3019129585 @default.
- W2725149750 hasConcept C547646559 @default.
- W2725149750 hasConcept C55493867 @default.
- W2725149750 hasConcept C71924100 @default.
- W2725149750 hasConceptScore W2725149750C142724271 @default.
- W2725149750 hasConceptScore W2725149750C16005928 @default.