FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2725613272> ?p ?o ?g. }

• W2725613272 endingPage "53" @default.
• W2725613272 startingPage "44" @default.
• W2725613272 abstract "Treatment of inflammatory kidney diseases with systemic high-dose glucocorticoids (GCs) has severe side effects. Liposomal encapsulation could facilitate local delivery of GCs to the inflamed kidney, as liposomes encapsulate their payload until extravasation at sites of inflammation, potentially resulting in local bioactivity. Our aim was to evaluate the ability of liposomes to accumulate locally after renal ischaemia-reperfusion injury in the rat and to study its effect on macrophages.In vitro, human macrophages were incubated with fluorescent liposomes, liposomal prednisolone, prednisolone, empty liposomes or saline. Uptake was studied microscopically and treatment effect was assessed by interkeukin 6 (IL-6) enzyme-linked immunosorbent assay. The mechanism of action was evaluated by analysing GC receptor activation by microscopy and quantitative polymerase chain reaction (qPCR). In vivo, rats were subjected to ischaemia-reperfusion injury and were injected intravenously with fluorescent liposomes, liposomal prednisolone, prednisolone, empty liposomes or saline. Uptake was measured by the FLARE camera and the treatment effect by immunohistochemistry for myeloid cells and qPCR for inflammatory markers.In vitro, macrophages internalized liposomes after 8 hours. Prednisolone or liposomal prednisolone treatment reduced IL-6 production and both compounds induced translocation of the GC receptor to the nucleus and upregulation of PER1 messenger RNA (mRNA), indicating a similar mechanism of action. In vivo, fluorescent liposomes accumulated in the inflamed kidney. Liposomal prednisolone treatment increased the presence of ED2-positive anti-inflammatory macrophages and both prednisolone and liposomal prednisolone reduced monocyte chemoattractant protein-1 (MCP-1) mRNA production, indicating a reduced pro-inflammatory profile in the kidney.Liposomal encapsulation is a promising strategy for local delivery of glucocorticoids to the inflamed kidney." @default.
• W2725613272 created "2017-07-14" @default.
• W2725613272 creator A5012617946 @default.
• W2725613272 creator A5013383577 @default.
• W2725613272 creator A5022741170 @default.
• W2725613272 creator A5027909548 @default.
• W2725613272 creator A5028075025 @default.
• W2725613272 creator A5035752811 @default.
• W2725613272 creator A5036035182 @default.
• W2725613272 creator A5040336579 @default.
• W2725613272 creator A5046358594 @default.
• W2725613272 creator A5053899866 @default.
• W2725613272 creator A5058384202 @default.
• W2725613272 creator A5060386892 @default.
• W2725613272 creator A5066436589 @default.
• W2725613272 creator A5069641539 @default.
• W2725613272 date "2017-07-08" @default.
• W2725613272 modified "2023-09-26" @default.
• W2725613272 title "Local delivery of liposomal prednisolone leads to an anti-inflammatory profile in renal ischaemia–reperfusion injury in the rat" @default.
• W2725613272 cites W1543892406 @default.
• W2725613272 cites W1916893403 @default.
• W2725613272 cites W1989501301 @default.
• W2725613272 cites W2002223683 @default.
• W2725613272 cites W2007021990 @default.
• W2725613272 cites W2007835360 @default.
• W2725613272 cites W2012867962 @default.
• W2725613272 cites W2032730667 @default.
• W2725613272 cites W2036093065 @default.
• W2725613272 cites W2044571134 @default.
• W2725613272 cites W2053449083 @default.
• W2725613272 cites W2055348159 @default.
• W2725613272 cites W2058310168 @default.
• W2725613272 cites W2059210868 @default.
• W2725613272 cites W2063838991 @default.
• W2725613272 cites W2065842089 @default.
• W2725613272 cites W2082046095 @default.
• W2725613272 cites W2098047948 @default.
• W2725613272 cites W2116467809 @default.
• W2725613272 cites W2119969731 @default.
• W2725613272 cites W2128177613 @default.
• W2725613272 cites W2148771210 @default.
• W2725613272 cites W2161580101 @default.
• W2725613272 cites W2164637490 @default.
• W2725613272 cites W2169222334 @default.
• W2725613272 cites W2274841233 @default.
• W2725613272 cites W2290961843 @default.
• W2725613272 cites W2301044272 @default.
• W2725613272 cites W2305354723 @default.
• W2725613272 cites W2353444611 @default.
• W2725613272 cites W2487037319 @default.
• W2725613272 cites W2529369348 @default.
• W2725613272 cites W2529913784 @default.
• W2725613272 doi "https://doi.org/10.1093/ndt/gfx204" @default.
• W2725613272 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28992069" @default.
• W2725613272 hasPublicationYear "2017" @default.
• W2725613272 type Work @default.
• W2725613272 sameAs 2725613272 @default.
• W2725613272 citedByCount "23" @default.
• W2725613272 countsByYear W27256132722019 @default.
• W2725613272 countsByYear W27256132722020 @default.
• W2725613272 countsByYear W27256132722021 @default.
• W2725613272 countsByYear W27256132722022 @default.
• W2725613272 countsByYear W27256132722023 @default.
• W2725613272 crossrefType "journal-article" @default.
• W2725613272 hasAuthorship W2725613272A5012617946 @default.
• W2725613272 hasAuthorship W2725613272A5013383577 @default.
• W2725613272 hasAuthorship W2725613272A5022741170 @default.
• W2725613272 hasAuthorship W2725613272A5027909548 @default.
• W2725613272 hasAuthorship W2725613272A5028075025 @default.
• W2725613272 hasAuthorship W2725613272A5035752811 @default.
• W2725613272 hasAuthorship W2725613272A5036035182 @default.
• W2725613272 hasAuthorship W2725613272A5040336579 @default.
• W2725613272 hasAuthorship W2725613272A5046358594 @default.
• W2725613272 hasAuthorship W2725613272A5053899866 @default.
• W2725613272 hasAuthorship W2725613272A5058384202 @default.
• W2725613272 hasAuthorship W2725613272A5060386892 @default.
• W2725613272 hasAuthorship W2725613272A5066436589 @default.
• W2725613272 hasAuthorship W2725613272A5069641539 @default.
• W2725613272 hasBestOaLocation W27256132721 @default.
• W2725613272 hasConcept C126322002 @default.
• W2725613272 hasConcept C150903083 @default.
• W2725613272 hasConcept C185154212 @default.
• W2725613272 hasConcept C185592680 @default.
• W2725613272 hasConcept C207001950 @default.
• W2725613272 hasConcept C2776715498 @default.
• W2725613272 hasConcept C2780091579 @default.
• W2725613272 hasConcept C2780114680 @default.
• W2725613272 hasConcept C2780721119 @default.
• W2725613272 hasConcept C541997718 @default.
• W2725613272 hasConcept C55493867 @default.
• W2725613272 hasConcept C71924100 @default.
• W2725613272 hasConcept C86803240 @default.
• W2725613272 hasConcept C98274493 @default.
• W2725613272 hasConceptScore W2725613272C126322002 @default.
• W2725613272 hasConceptScore W2725613272C150903083 @default.
• W2725613272 hasConceptScore W2725613272C185154212 @default.
• W2725613272 hasConceptScore W2725613272C185592680 @default.
• W2725613272 hasConceptScore W2725613272C207001950 @default.

• next