Matches in SemOpenAlex for { <https://semopenalex.org/work/W2725680457> ?p ?o ?g. }
- W2725680457 endingPage "698" @default.
- W2725680457 startingPage "689" @default.
- W2725680457 abstract "The nucleus accumbens (NAc) is a critical component of the mesocorticolimbic system and is involved in mediating the motivational and reinforcing aspects of ethanol consumption. Chronic intermittent ethanol (CIE) exposure is a reliable model to induce ethanol dependence and increase volitional ethanol consumption in mice. Following a CIE-induced escalation of ethanol consumption, NMDAR (N-methyl-D-aspartate receptor)-dependent long-term depression in D1 dopamine receptor expressing medium spiny neurons of the NAc shell was markedly altered with no changes in plasticity in D1 dopamine receptor medium spiny neurons from the NAc core. This disruption of plasticity persisted for up to 2 weeks after cessation of ethanol access. To determine if changes in AMPA receptor (AMPAR) composition contribute to this ethanol-induced neuroadaptation, we monitored the rectification of AMPAR excitatory postsynaptic currents (EPSCs). We observed a marked decrease in the rectification index in the NAc shell, suggesting the presence of GluA2-lacking AMPARs. There was no change in the amplitude of spontaneous EPSCs (sEPSCs), but there was a transient increase in sEPSC frequency in the NAc shell. Using the paired pulse ratio, we detected a similar transient increase in the probability of neurotransmitter release. With no change in sEPSC amplitude, the change in the rectification index suggests that GluA2-containing AMPARs are removed and replaced with GluA2-lacking AMPARs in the NAc shell. This CIE-induced alteration in AMPAR subunit composition may contribute to the loss of NMDAR-dependent long-term depression in the NAc shell and therefore may constitute a critical neuroadaptive response underlying the escalation of ethanol intake in the CIE model." @default.
- W2725680457 created "2017-07-14" @default.
- W2725680457 creator A5011979128 @default.
- W2725680457 creator A5015035371 @default.
- W2725680457 creator A5062178392 @default.
- W2725680457 date "2017-06-28" @default.
- W2725680457 modified "2023-10-17" @default.
- W2725680457 title "Long-term subregion-specific encoding of enhanced ethanol intake by D1DR medium spiny neurons of the nucleus accumbens" @default.
- W2725680457 cites W1485031809 @default.
- W2725680457 cites W150093770 @default.
- W2725680457 cites W1596199244 @default.
- W2725680457 cites W1598659526 @default.
- W2725680457 cites W1902012815 @default.
- W2725680457 cites W1918535853 @default.
- W2725680457 cites W1932011703 @default.
- W2725680457 cites W1965110331 @default.
- W2725680457 cites W1970874792 @default.
- W2725680457 cites W1971690948 @default.
- W2725680457 cites W1972949334 @default.
- W2725680457 cites W1973399876 @default.
- W2725680457 cites W1977077283 @default.
- W2725680457 cites W1978625035 @default.
- W2725680457 cites W1980667163 @default.
- W2725680457 cites W1982298072 @default.
- W2725680457 cites W1984224738 @default.
- W2725680457 cites W1987256529 @default.
- W2725680457 cites W1992208327 @default.
- W2725680457 cites W1993782794 @default.
- W2725680457 cites W2001351189 @default.
- W2725680457 cites W2008846482 @default.
- W2725680457 cites W2009263295 @default.
- W2725680457 cites W2011308569 @default.
- W2725680457 cites W2026984303 @default.
- W2725680457 cites W2036768211 @default.
- W2725680457 cites W2048808552 @default.
- W2725680457 cites W2066771173 @default.
- W2725680457 cites W2068137434 @default.
- W2725680457 cites W2071194748 @default.
- W2725680457 cites W2072523275 @default.
- W2725680457 cites W2074600592 @default.
- W2725680457 cites W2076624461 @default.
- W2725680457 cites W2092533548 @default.
- W2725680457 cites W2092990950 @default.
- W2725680457 cites W2103233885 @default.
- W2725680457 cites W2126663915 @default.
- W2725680457 cites W2127699867 @default.
- W2725680457 cites W2138524791 @default.
- W2725680457 cites W2149885167 @default.
- W2725680457 cites W2165292976 @default.
- W2725680457 cites W2165398609 @default.
- W2725680457 cites W2178902776 @default.
- W2725680457 cites W2231467691 @default.
- W2725680457 cites W2294314751 @default.
- W2725680457 cites W2528157783 @default.
- W2725680457 cites W4205282404 @default.
- W2725680457 cites W4246659915 @default.
- W2725680457 doi "https://doi.org/10.1111/adb.12526" @default.
- W2725680457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6264790" @default.
- W2725680457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28656742" @default.
- W2725680457 hasPublicationYear "2017" @default.
- W2725680457 type Work @default.
- W2725680457 sameAs 2725680457 @default.
- W2725680457 citedByCount "23" @default.
- W2725680457 countsByYear W27256804572017 @default.
- W2725680457 countsByYear W27256804572018 @default.
- W2725680457 countsByYear W27256804572019 @default.
- W2725680457 countsByYear W27256804572020 @default.
- W2725680457 countsByYear W27256804572021 @default.
- W2725680457 countsByYear W27256804572023 @default.
- W2725680457 crossrefType "journal-article" @default.
- W2725680457 hasAuthorship W2725680457A5011979128 @default.
- W2725680457 hasAuthorship W2725680457A5015035371 @default.
- W2725680457 hasAuthorship W2725680457A5062178392 @default.
- W2725680457 hasBestOaLocation W27256804572 @default.
- W2725680457 hasConcept C112592302 @default.
- W2725680457 hasConcept C126322002 @default.
- W2725680457 hasConcept C160268369 @default.
- W2725680457 hasConcept C169760540 @default.
- W2725680457 hasConcept C170493617 @default.
- W2725680457 hasConcept C185592680 @default.
- W2725680457 hasConcept C2776552330 @default.
- W2725680457 hasConcept C2780062018 @default.
- W2725680457 hasConcept C2780648746 @default.
- W2725680457 hasConcept C513476851 @default.
- W2725680457 hasConcept C55493867 @default.
- W2725680457 hasConcept C61174792 @default.
- W2725680457 hasConcept C67018056 @default.
- W2725680457 hasConcept C71924100 @default.
- W2725680457 hasConcept C85714458 @default.
- W2725680457 hasConcept C86803240 @default.
- W2725680457 hasConcept C98229152 @default.
- W2725680457 hasConceptScore W2725680457C112592302 @default.
- W2725680457 hasConceptScore W2725680457C126322002 @default.
- W2725680457 hasConceptScore W2725680457C160268369 @default.
- W2725680457 hasConceptScore W2725680457C169760540 @default.
- W2725680457 hasConceptScore W2725680457C170493617 @default.
- W2725680457 hasConceptScore W2725680457C185592680 @default.
- W2725680457 hasConceptScore W2725680457C2776552330 @default.