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- W2725713057 abstract "The entry point of the spermatozoon dictates the placement of the animal pole and thus the dorsoventral axis of the early embryo, eliminating the once-radial symmetry of the egg. Radial symmetry is further broken by the primitive streak, demarcating the left–right and rostral–caudal axes. This newfound bilateral symmetry is short-lived, however, disturbed by development of the (generally) right-sided loop formation of the heart tube and subsequent asymmetrically placed organ systems, such as the liver, spleen, and digestive tract ( 1 Levin M. Left-right asymmetry in embryonic development: A comprehensive review. Mech Dev. 2005; 122: 3-25 Crossref PubMed Scopus (373) Google Scholar ). Left–Right Asymmetry of Maturation Rates in Human Embryonic Neural DevelopmentBiological PsychiatryVol. 82Issue 3PreviewLeft–right asymmetry is a fundamental organizing feature of the human brain, and neuropsychiatric disorders such as schizophrenia sometimes involve alterations of brain asymmetry. As early as 8 weeks postconception, the majority of human fetuses move their right arms more than their left arms, but because nerve fiber tracts are still descending from the forebrain at this stage, spinal–muscular asymmetries are likely to play an important developmental role. Full-Text PDF" @default.
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- W2725713057 date "2017-08-01" @default.
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- W2725713057 title "Links Between Patterns of Embryonic Spinal Cord Development and Schizophrenia Risk" @default.
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- W2725713057 doi "https://doi.org/10.1016/j.biopsych.2017.05.006" @default.
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