FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2726026710> ?p ?o ?g. }

• W2726026710 endingPage "e0178693" @default.
• W2726026710 startingPage "e0178693" @default.
• W2726026710 abstract "Expression of the base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG) has been correlated to temozolomide resistance. Our aim was to evaluate the prognostic value of APNG in a population-based cohort with 242 gliomas including 185 glioblastomas (GBMs). Cellular heterogeneity of GBMs was taken into account by excluding APNG expression in non-tumor cells from the analysis.APNG expression was evaluated using automated image analysis and a novel quantitative immunohistochemical (IHC) assay (qIHC), where APNG protein expression was evaluated through countable dots. Non-tumor cells were excluded using an IHC/qIHC double-staining. For verification, APNG was measured by a quantitative double-immunofluorescence (IF) assay. As validation APNG mRNA expression was evaluated using independent TCGA data.Using qIHC, high levels of APNG were associated with better overall survival (OS) in univariate (HR = 0.50; P < 0.001) and multivariate analysis (HR = 0.53; P = 0.001). Patients with methylated MGMT promoters and high APNG expression demonstrated better OS, than patients with methylated MGMT promoters and low APNG expression (HR = 0.59; P = 0.08). Retesting the cohort using IF showed similar results in both univariate (HR = 0.61; P = 0.002) and multivariate analysis (HR = 0.81; P = 0.2). The results were supported by data from the TCGA database.Using two different assays combined with quantitative image analysis excluding non-tumour cells, APNG was an independent prognostic factor among patients with a methylated MGMT promoter. We expect that APNG qIHC can potentially identify GBM patients who will not benefit from treatment with temozolomide." @default.
• W2726026710 created "2017-07-14" @default.
• W2726026710 creator A5006967689 @default.
• W2726026710 creator A5012475563 @default.
• W2726026710 creator A5023573690 @default.
• W2726026710 creator A5037276792 @default.
• W2726026710 creator A5040673976 @default.
• W2726026710 creator A5061521917 @default.
• W2726026710 creator A5073102947 @default.
• W2726026710 creator A5079942296 @default.
• W2726026710 creator A5087693816 @default.
• W2726026710 date "2017-06-29" @default.
• W2726026710 modified "2023-09-28" @default.
• W2726026710 title "APNG as a prognostic marker in patients with glioblastoma" @default.
• W2726026710 cites W1456958198 @default.
• W2726026710 cites W1893588436 @default.
• W2726026710 cites W1922368942 @default.
• W2726026710 cites W1982626083 @default.
• W2726026710 cites W1992394750 @default.
• W2726026710 cites W2024392741 @default.
• W2726026710 cites W2025183726 @default.
• W2726026710 cites W2049606715 @default.
• W2726026710 cites W2052597531 @default.
• W2726026710 cites W2058468080 @default.
• W2726026710 cites W2063979552 @default.
• W2726026710 cites W2067517706 @default.
• W2726026710 cites W2076644266 @default.
• W2726026710 cites W2079203845 @default.
• W2726026710 cites W2087821380 @default.
• W2726026710 cites W2092033495 @default.
• W2726026710 cites W2094144162 @default.
• W2726026710 cites W2096287682 @default.
• W2726026710 cites W2098461884 @default.
• W2726026710 cites W2101624899 @default.
• W2726026710 cites W2105100844 @default.
• W2726026710 cites W2107731988 @default.
• W2726026710 cites W2118270453 @default.
• W2726026710 cites W2144941946 @default.
• W2726026710 cites W2154526619 @default.
• W2726026710 cites W2155524619 @default.
• W2726026710 cites W2158649478 @default.
• W2726026710 cites W2158681922 @default.
• W2726026710 cites W2160382843 @default.
• W2726026710 cites W2161876414 @default.
• W2726026710 cites W2165871546 @default.
• W2726026710 cites W2168429973 @default.
• W2726026710 cites W2230695574 @default.
• W2726026710 cites W2263206910 @default.
• W2726026710 cites W2315877926 @default.
• W2726026710 cites W236769407 @default.
• W2726026710 cites W2538484238 @default.
• W2726026710 cites W296294136 @default.
• W2726026710 cites W4255617418 @default.
• W2726026710 cites W64127387 @default.
• W2726026710 doi "https://doi.org/10.1371/journal.pone.0178693" @default.
• W2726026710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5490991" @default.
• W2726026710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28662073" @default.
• W2726026710 hasPublicationYear "2017" @default.
• W2726026710 type Work @default.
• W2726026710 sameAs 2726026710 @default.
• W2726026710 citedByCount "11" @default.
• W2726026710 countsByYear W27260267102018 @default.
• W2726026710 countsByYear W27260267102019 @default.
• W2726026710 countsByYear W27260267102020 @default.
• W2726026710 countsByYear W27260267102021 @default.
• W2726026710 countsByYear W27260267102022 @default.
• W2726026710 crossrefType "journal-article" @default.
• W2726026710 hasAuthorship W2726026710A5006967689 @default.
• W2726026710 hasAuthorship W2726026710A5012475563 @default.
• W2726026710 hasAuthorship W2726026710A5023573690 @default.
• W2726026710 hasAuthorship W2726026710A5037276792 @default.
• W2726026710 hasAuthorship W2726026710A5040673976 @default.
• W2726026710 hasAuthorship W2726026710A5061521917 @default.
• W2726026710 hasAuthorship W2726026710A5073102947 @default.
• W2726026710 hasAuthorship W2726026710A5079942296 @default.
• W2726026710 hasAuthorship W2726026710A5087693816 @default.
• W2726026710 hasBestOaLocation W27260267101 @default.
• W2726026710 hasConcept C104317684 @default.
• W2726026710 hasConcept C105795698 @default.
• W2726026710 hasConcept C126322002 @default.
• W2726026710 hasConcept C142724271 @default.
• W2726026710 hasConcept C143998085 @default.
• W2726026710 hasConcept C144301174 @default.
• W2726026710 hasConcept C161584116 @default.
• W2726026710 hasConcept C199163554 @default.
• W2726026710 hasConcept C204232928 @default.
• W2726026710 hasConcept C2777389519 @default.
• W2726026710 hasConcept C2778227246 @default.
• W2726026710 hasConcept C2779527866 @default.
• W2726026710 hasConcept C2908647359 @default.
• W2726026710 hasConcept C33288867 @default.
• W2726026710 hasConcept C33923547 @default.
• W2726026710 hasConcept C38180746 @default.
• W2726026710 hasConcept C502942594 @default.
• W2726026710 hasConcept C54355233 @default.
• W2726026710 hasConcept C71924100 @default.
• W2726026710 hasConcept C86803240 @default.
• W2726026710 hasConcept C91965660 @default.

• next