FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2726052546> ?p ?o ?g. }

• W2726052546 endingPage "e0180246" @default.
• W2726052546 startingPage "e0180246" @default.
• W2726052546 abstract "During adaptation to host environments, many microorganisms alter their cell surface. One mechanism for doing so is variation in the number of amino acid repeats in cell surface proteins encoded by hypermutable DNA tandem repeats. In the yeast Candida albicans, an opportunistic human pathogen, the gene SSR1 encodes a GPI-anchored cell wall protein with a structural role. It contains two regions consisting of tandem repeats, almost exclusively encoding the amino acid pair Ser-Ala. As expected, the repeat regions make SSR1 highly mutable. New SSR1 alleles arose with a frequency of 1.11×10−4 per cell division in serially propagated cells. We also observed a large number (25) of SSR1 alleles with different repeat lengths in a survey of 131 isolates from a global strain collection. C. albicans is diploid, and combinations of these allele generated 41 different SSR1 genotypes. In both repeat regions, nonsynonymous mutations were largely restricted to one particular repeat unit. Two very similar allele combinations were largely restricted to one clade, clade 1. Each combination was present in ~30% of 49 infection-causing clade 1 strains, but one was rare (2%), the other absent in 46 infection-causing strains representing the remainder of the species (P < 0.00018 and 0.00004; Fisher’s exact test). These results indicate that both repeat regions are under selection and that amino acid repeat length polymorphisms generate Ssr1 protein variants most suitable for specific genetic backgrounds. One of these two allele combinations was 5.51 times more frequent, the other 1.75 times less frequent in 49 clade 1 strains that caused disease than in 36 commensal clade 1 strains (P = 0.0105; Chi2 test). This indicates that insertion and deletion of repeats not only generates clade-optimized Ssr1p variants, but may also assist in short-term adaptation when C. albicans makes the transition from commensal to pathogen." @default.
• W2726052546 created "2017-07-14" @default.
• W2726052546 creator A5000659094 @default.
• W2726052546 creator A5005266890 @default.
• W2726052546 creator A5055770784 @default.
• W2726052546 creator A5067216660 @default.
• W2726052546 creator A5090063697 @default.
• W2726052546 date "2017-06-29" @default.
• W2726052546 modified "2023-09-23" @default.
• W2726052546 title "Highly mutable tandem DNA repeats generate a cell wall protein variant more frequent in disease-causing Candida albicans isolates than in commensal isolates" @default.
• W2726052546 cites W1508013021 @default.
• W2726052546 cites W1579877598 @default.
• W2726052546 cites W1717348303 @default.
• W2726052546 cites W1821668945 @default.
• W2726052546 cites W1859242199 @default.
• W2726052546 cites W1873719116 @default.
• W2726052546 cites W1964020301 @default.
• W2726052546 cites W1968502165 @default.
• W2726052546 cites W1972967985 @default.
• W2726052546 cites W1984563346 @default.
• W2726052546 cites W1995287854 @default.
• W2726052546 cites W1996489389 @default.
• W2726052546 cites W2004093637 @default.
• W2726052546 cites W2004432131 @default.
• W2726052546 cites W2032776824 @default.
• W2726052546 cites W2043618419 @default.
• W2726052546 cites W2060322845 @default.
• W2726052546 cites W2063387463 @default.
• W2726052546 cites W2068022821 @default.
• W2726052546 cites W2076847153 @default.
• W2726052546 cites W2089485694 @default.
• W2726052546 cites W2096081430 @default.
• W2726052546 cites W2097413462 @default.
• W2726052546 cites W2113632611 @default.
• W2726052546 cites W2125994797 @default.
• W2726052546 cites W2126323553 @default.
• W2726052546 cites W2138101634 @default.
• W2726052546 cites W2139620187 @default.
• W2726052546 cites W2141563676 @default.
• W2726052546 cites W2145406188 @default.
• W2726052546 cites W2146537281 @default.
• W2726052546 cites W2153075143 @default.
• W2726052546 cites W2153252627 @default.
• W2726052546 cites W2158782081 @default.
• W2726052546 cites W2161815244 @default.
• W2726052546 cites W2165537776 @default.
• W2726052546 cites W2168705804 @default.
• W2726052546 cites W4235514032 @default.
• W2726052546 doi "https://doi.org/10.1371/journal.pone.0180246" @default.
• W2726052546 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5491155" @default.
• W2726052546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28662107" @default.
• W2726052546 hasPublicationYear "2017" @default.
• W2726052546 type Work @default.
• W2726052546 sameAs 2726052546 @default.
• W2726052546 citedByCount "6" @default.
• W2726052546 countsByYear W27260525462018 @default.
• W2726052546 countsByYear W27260525462019 @default.
• W2726052546 countsByYear W27260525462022 @default.
• W2726052546 countsByYear W27260525462023 @default.
• W2726052546 crossrefType "journal-article" @default.
• W2726052546 hasAuthorship W2726052546A5000659094 @default.
• W2726052546 hasAuthorship W2726052546A5005266890 @default.
• W2726052546 hasAuthorship W2726052546A5055770784 @default.
• W2726052546 hasAuthorship W2726052546A5067216660 @default.
• W2726052546 hasAuthorship W2726052546A5090063697 @default.
• W2726052546 hasBestOaLocation W27260525461 @default.
• W2726052546 hasConcept C104317684 @default.
• W2726052546 hasConcept C135763542 @default.
• W2726052546 hasConcept C141231307 @default.
• W2726052546 hasConcept C145081991 @default.
• W2726052546 hasConcept C149904235 @default.
• W2726052546 hasConcept C180754005 @default.
• W2726052546 hasConcept C27149982 @default.
• W2726052546 hasConcept C2780917455 @default.
• W2726052546 hasConcept C54355233 @default.
• W2726052546 hasConcept C86803240 @default.
• W2726052546 hasConceptScore W2726052546C104317684 @default.
• W2726052546 hasConceptScore W2726052546C135763542 @default.
• W2726052546 hasConceptScore W2726052546C141231307 @default.
• W2726052546 hasConceptScore W2726052546C145081991 @default.
• W2726052546 hasConceptScore W2726052546C149904235 @default.
• W2726052546 hasConceptScore W2726052546C180754005 @default.
• W2726052546 hasConceptScore W2726052546C27149982 @default.
• W2726052546 hasConceptScore W2726052546C2780917455 @default.
• W2726052546 hasConceptScore W2726052546C54355233 @default.
• W2726052546 hasConceptScore W2726052546C86803240 @default.
• W2726052546 hasFunder F4320320782 @default.
• W2726052546 hasIssue "6" @default.
• W2726052546 hasLocation W27260525461 @default.
• W2726052546 hasLocation W27260525462 @default.
• W2726052546 hasLocation W27260525463 @default.
• W2726052546 hasLocation W27260525464 @default.
• W2726052546 hasOpenAccess W2726052546 @default.
• W2726052546 hasPrimaryLocation W27260525461 @default.
• W2726052546 hasRelatedWork W1985973072 @default.
• W2726052546 hasRelatedWork W1994789888 @default.
• W2726052546 hasRelatedWork W2029056863 @default.
• W2726052546 hasRelatedWork W2057739827 @default.

• next