Matches in SemOpenAlex for { <https://semopenalex.org/work/W2726161792> ?p ?o ?g. }
- W2726161792 endingPage "2096" @default.
- W2726161792 startingPage "2087" @default.
- W2726161792 abstract "ABSTRACT Nuclear lamins are components of the peripheral lamina that define the mechanical properties of nuclei and tether heterochromatin to the periphery. A-type lamins localize also to the nuclear interior, but the regulation and specific functions of this nucleoplasmic lamin pool are poorly understood. In this Commentary, we summarize known pathways that are potentially involved in the localization and dynamic behavior of intranuclear lamins, including their post-translational modifications and interactions with nucleoplasmic proteins, such as lamina-associated polypeptide 2α (LAP2α; encoded by TMPO). In addition, new data suggest that lamins in the nuclear interior have an important role in chromatin regulation and gene expression through dynamic binding to both hetero- and euchromatic genomic regions and promoter subdomains, thereby affecting epigenetic pathways and chromatin accessibility. Nucleoplasmic lamins also have a role in spatial chromatin organization and may be involved in mechanosignaling. In view of this newly emerging concept, we propose that the previously reported cellular phenotypes in lamin-linked diseases are, at least in part, rooted in an impaired regulation and/or function of the nucleoplasmic lamin A/C pool." @default.
- W2726161792 created "2017-07-14" @default.
- W2726161792 creator A5000334283 @default.
- W2726161792 creator A5034385806 @default.
- W2726161792 creator A5081263278 @default.
- W2726161792 date "2017-07-01" @default.
- W2726161792 modified "2023-10-12" @default.
- W2726161792 title "Lamins in the nuclear interior − life outside the lamina" @default.
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