Matches in SemOpenAlex for { <https://semopenalex.org/work/W2726311377> ?p ?o ?g. }
- W2726311377 abstract "Abstract Cystic fibrosis transmembrane conductance regulator (CFTR), known as a cAMP-activated Cl − channel, is widely expressed at the apical membrane of epithelial cells in a wide variety of tissues. Of note, despite the abundant expression of CFTR in mammalian kidney, the role of CFTR in kidney disease development is unclear. Here, we report that CFTR expression is downregulated in the UUO (unilateral ureteral obstruction)-induced kidney fibrosis mouse model and human fibrotic kidneys. Dysfunction or downregulation of CFTR in renal epithelial cells leads to alteration of genes involved in Epithelial-Mesenchymal Transition (EMT) and kidney fibrosis. In addition, dysregulation of CFTR activates canonical Wnt/β-catenin signaling pathways, whereas the β-catenin inhibitor reverses the effects of CFTR downregulation on EMT marker. More interestingly, CFTR interacts with Dishevelled 2 (Dvl2), a key component of Wnt signaling, thereby suppressing the activation of β-catenin. Compared to wild type, delta F508 mice with UUO treatment exhibit significantly higher β-catenin activity with aggregated kidney fibrogenesis, which is reduced by forced overexpression of CFTR. Taken together, our study reveals a novel mechanism by which CFTR regulates Wnt/β-catenin signaling pertinent to progression of kidney fibrosis and indicates a potential treatment target." @default.
- W2726311377 created "2017-07-14" @default.
- W2726311377 creator A5003642180 @default.
- W2726311377 creator A5012963597 @default.
- W2726311377 creator A5025234353 @default.
- W2726311377 creator A5033549252 @default.
- W2726311377 creator A5053170113 @default.
- W2726311377 creator A5061472855 @default.
- W2726311377 creator A5063428071 @default.
- W2726311377 creator A5063815252 @default.
- W2726311377 creator A5069262051 @default.
- W2726311377 creator A5070124104 @default.
- W2726311377 creator A5086372378 @default.
- W2726311377 date "2017-07-12" @default.
- W2726311377 modified "2023-10-17" @default.
- W2726311377 title "Defective CFTR leads to aberrant β-catenin activation and kidney fibrosis" @default.
- W2726311377 cites W1566750909 @default.
- W2726311377 cites W1965151940 @default.
- W2726311377 cites W1969109536 @default.
- W2726311377 cites W1982069914 @default.
- W2726311377 cites W1987979328 @default.
- W2726311377 cites W1997222184 @default.
- W2726311377 cites W2001176233 @default.
- W2726311377 cites W2002518738 @default.
- W2726311377 cites W2009888336 @default.
- W2726311377 cites W2010702553 @default.
- W2726311377 cites W2011409573 @default.
- W2726311377 cites W2016713016 @default.
- W2726311377 cites W2022083755 @default.
- W2726311377 cites W2023121345 @default.
- W2726311377 cites W2028171116 @default.
- W2726311377 cites W2028422283 @default.
- W2726311377 cites W2032942532 @default.
- W2726311377 cites W2036044995 @default.
- W2726311377 cites W2039599894 @default.
- W2726311377 cites W2049914201 @default.
- W2726311377 cites W2051446765 @default.
- W2726311377 cites W2052092179 @default.
- W2726311377 cites W2054282870 @default.
- W2726311377 cites W2057292199 @default.
- W2726311377 cites W2062996047 @default.
- W2726311377 cites W2071441516 @default.
- W2726311377 cites W2078818437 @default.
- W2726311377 cites W2079108159 @default.
- W2726311377 cites W2080347068 @default.
- W2726311377 cites W2086508420 @default.
- W2726311377 cites W2089656877 @default.
- W2726311377 cites W2094383804 @default.
- W2726311377 cites W2103777275 @default.
- W2726311377 cites W2104354608 @default.
- W2726311377 cites W2105611069 @default.
- W2726311377 cites W2105749548 @default.
- W2726311377 cites W2112048001 @default.
- W2726311377 cites W2116512140 @default.
- W2726311377 cites W2122301601 @default.
- W2726311377 cites W2132521165 @default.
- W2726311377 cites W2132803823 @default.
- W2726311377 cites W2137769557 @default.
- W2726311377 cites W2138713501 @default.
- W2726311377 cites W2142278869 @default.
- W2726311377 cites W2143227567 @default.
- W2726311377 cites W2147821592 @default.
- W2726311377 cites W2149879690 @default.
- W2726311377 cites W2150900324 @default.
- W2726311377 cites W2155681713 @default.
- W2726311377 cites W2157854594 @default.
- W2726311377 cites W2158118120 @default.
- W2726311377 cites W2158458517 @default.
- W2726311377 cites W2160109224 @default.
- W2726311377 cites W2167446786 @default.
- W2726311377 cites W2169453638 @default.
- W2726311377 cites W2170653875 @default.
- W2726311377 cites W2188967200 @default.
- W2726311377 cites W2234614402 @default.
- W2726311377 cites W2417117612 @default.
- W2726311377 cites W2517315109 @default.
- W2726311377 cites W2534751651 @default.
- W2726311377 cites W2554681824 @default.
- W2726311377 cites W2575959764 @default.
- W2726311377 cites W2582114155 @default.
- W2726311377 cites W2597632520 @default.
- W2726311377 cites W4244774747 @default.
- W2726311377 cites W4250450758 @default.
- W2726311377 cites W4250731522 @default.
- W2726311377 doi "https://doi.org/10.1038/s41598-017-05435-5" @default.
- W2726311377 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5507915" @default.
- W2726311377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28701694" @default.
- W2726311377 hasPublicationYear "2017" @default.
- W2726311377 type Work @default.
- W2726311377 sameAs 2726311377 @default.
- W2726311377 citedByCount "23" @default.
- W2726311377 countsByYear W27263113772018 @default.
- W2726311377 countsByYear W27263113772019 @default.
- W2726311377 countsByYear W27263113772020 @default.
- W2726311377 countsByYear W27263113772021 @default.
- W2726311377 countsByYear W27263113772022 @default.
- W2726311377 countsByYear W27263113772023 @default.
- W2726311377 crossrefType "journal-article" @default.
- W2726311377 hasAuthorship W2726311377A5003642180 @default.
- W2726311377 hasAuthorship W2726311377A5012963597 @default.