Matches in SemOpenAlex for { <https://semopenalex.org/work/W2726346191> ?p ?o ?g. }
- W2726346191 endingPage "958" @default.
- W2726346191 startingPage "949" @default.
- W2726346191 abstract "Breast cancer is the most common carcinoma among Chinese women. Interferon α (IFNα) has been used to treat various types of cancer, including breast cancer, but its antitumor activity is relative low, which significantly hinders its clinical application. In this study, we utilized a Ph.D.-12 peptide library screening system to identify a short peptide that specifically binds to MCF-7 breast cancer cells. By fusing the MCF-7 binding peptide (MBP) to the C-terminus of IFNα, we constructed an engineered IFNα-MBP fusion molecule (IMBP), and applied this novel fusion protein to the treatment of breast cancer. We found that IMBP exhibited significantly higher activity than wild-type IFNα in inhibiting cell growth and inducing cell apoptosis. Additionally, IMBP potentiated the therapeutic efficacy of doxorubicin-based breast cancer chemotherapy via the activation of cell cycle arrest and cell apoptosis pathway genes including p53, p21, CDK2, cyclin A, caspase 9, Bcl-2 and Bax. The enhanced activity of the synthetic IMBP was also associated with the activation of signal transducer and activation of transcription 1 (STAT1) pathway target genes (STAT1, IFIT1, IFITM1 and MX1). This study evaluated the potential value of the synthetic IMBP as a novel anti-breast cancer agent." @default.
- W2726346191 created "2017-07-14" @default.
- W2726346191 creator A5000319667 @default.
- W2726346191 creator A5006096139 @default.
- W2726346191 creator A5009855534 @default.
- W2726346191 creator A5020381388 @default.
- W2726346191 creator A5023056600 @default.
- W2726346191 creator A5030857408 @default.
- W2726346191 creator A5042080721 @default.
- W2726346191 creator A5080476738 @default.
- W2726346191 creator A5083869437 @default.
- W2726346191 date "2017-07-03" @default.
- W2726346191 modified "2023-09-29" @default.
- W2726346191 title "A novel engineered interferon-α hybrid molecule increases anticancer efficacy of doxorubicin in breast cancer chemotherapy" @default.
- W2726346191 cites W1513499452 @default.
- W2726346191 cites W1546466517 @default.
- W2726346191 cites W1757407923 @default.
- W2726346191 cites W1989053528 @default.
- W2726346191 cites W2002323018 @default.
- W2726346191 cites W2013284605 @default.
- W2726346191 cites W2015544673 @default.
- W2726346191 cites W2017010917 @default.
- W2726346191 cites W2031472841 @default.
- W2726346191 cites W2037265356 @default.
- W2726346191 cites W2038428454 @default.
- W2726346191 cites W2042698015 @default.
- W2726346191 cites W2055651218 @default.
- W2726346191 cites W2083296039 @default.
- W2726346191 cites W2090920304 @default.
- W2726346191 cites W2096655588 @default.
- W2726346191 cites W2109150316 @default.
- W2726346191 cites W2120336534 @default.
- W2726346191 cites W2124600450 @default.
- W2726346191 cites W2132207113 @default.
- W2726346191 cites W2180878036 @default.
- W2726346191 cites W2194880636 @default.
- W2726346191 cites W2216340565 @default.
- W2726346191 cites W2275249553 @default.
- W2726346191 cites W2346417149 @default.
- W2726346191 cites W2347085671 @default.
- W2726346191 cites W2411882159 @default.
- W2726346191 cites W2473252551 @default.
- W2726346191 cites W2554134245 @default.
- W2726346191 cites W2596486024 @default.
- W2726346191 cites W5122860 @default.
- W2726346191 doi "https://doi.org/10.3892/ijo.2017.4062" @default.
- W2726346191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28677808" @default.
- W2726346191 hasPublicationYear "2017" @default.
- W2726346191 type Work @default.
- W2726346191 sameAs 2726346191 @default.
- W2726346191 citedByCount "1" @default.
- W2726346191 countsByYear W27263461912022 @default.
- W2726346191 crossrefType "journal-article" @default.
- W2726346191 hasAuthorship W2726346191A5000319667 @default.
- W2726346191 hasAuthorship W2726346191A5006096139 @default.
- W2726346191 hasAuthorship W2726346191A5009855534 @default.
- W2726346191 hasAuthorship W2726346191A5020381388 @default.
- W2726346191 hasAuthorship W2726346191A5023056600 @default.
- W2726346191 hasAuthorship W2726346191A5030857408 @default.
- W2726346191 hasAuthorship W2726346191A5042080721 @default.
- W2726346191 hasAuthorship W2726346191A5080476738 @default.
- W2726346191 hasAuthorship W2726346191A5083869437 @default.
- W2726346191 hasBestOaLocation W27263461911 @default.
- W2726346191 hasConcept C121608353 @default.
- W2726346191 hasConcept C190283241 @default.
- W2726346191 hasConcept C203014093 @default.
- W2726346191 hasConcept C2776178377 @default.
- W2726346191 hasConcept C2776694085 @default.
- W2726346191 hasConcept C2777003663 @default.
- W2726346191 hasConcept C2781303535 @default.
- W2726346191 hasConcept C29537977 @default.
- W2726346191 hasConcept C502942594 @default.
- W2726346191 hasConcept C530470458 @default.
- W2726346191 hasConcept C54355233 @default.
- W2726346191 hasConcept C55493867 @default.
- W2726346191 hasConcept C86803240 @default.
- W2726346191 hasConcept C96232424 @default.
- W2726346191 hasConceptScore W2726346191C121608353 @default.
- W2726346191 hasConceptScore W2726346191C190283241 @default.
- W2726346191 hasConceptScore W2726346191C203014093 @default.
- W2726346191 hasConceptScore W2726346191C2776178377 @default.
- W2726346191 hasConceptScore W2726346191C2776694085 @default.
- W2726346191 hasConceptScore W2726346191C2777003663 @default.
- W2726346191 hasConceptScore W2726346191C2781303535 @default.
- W2726346191 hasConceptScore W2726346191C29537977 @default.
- W2726346191 hasConceptScore W2726346191C502942594 @default.
- W2726346191 hasConceptScore W2726346191C530470458 @default.
- W2726346191 hasConceptScore W2726346191C54355233 @default.
- W2726346191 hasConceptScore W2726346191C55493867 @default.
- W2726346191 hasConceptScore W2726346191C86803240 @default.
- W2726346191 hasConceptScore W2726346191C96232424 @default.
- W2726346191 hasIssue "3" @default.
- W2726346191 hasLocation W27263461911 @default.
- W2726346191 hasLocation W27263461912 @default.
- W2726346191 hasOpenAccess W2726346191 @default.
- W2726346191 hasPrimaryLocation W27263461911 @default.
- W2726346191 hasRelatedWork W2341629494 @default.
- W2726346191 hasRelatedWork W2348413169 @default.