FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2726401904> ?p ?o ?g. }

• W2726401904 endingPage "667" @default.
• W2726401904 startingPage "660" @default.
• W2726401904 abstract "Abstract Asiatic acid (AA) could attenuate ischemia/reperfusion induced myocardial apoptosis through upregulating the Akt/GSK‐3β/HIF‐1α pathway. HIF‐3α is a negative regulator of HIF‐1α, whose mRNA is a potential target of miR‐1290. AA could upregulate miR‐1290 in non‐small‐cell lung cancer A549 cells. This work aimed to investigate whether AA could inhibit hypoxia induced cardiomyocyte apoptosis through regulating the miR‐1290/HIF3A/HIF‐1α axis. The AC16 human myocardial cell line cultured under normoxic or hypoxic conditions was treated with various doses of AA for 24 h. Afterwards cell viability, apoptosis and the expression of miR‐1290, HIF3A, and HIF1A were evaluated. Cells transfected with miR‐1290 mimic or inhibitor were used to determine the role of miR‐1290 in the anti‐apoptosis effect of AA and the expression of HIF3A and HIF1A. Dual luciferase assay was performed to confirm miR‐1290 targeting of HIF3A. HIF3A overexpression was achieved by transfection of HIF3A1 overexpressing lentivirus, and its effect on miR‐1290 and AA‐regulated survival of cardiomyocytes was evaluated. AA treatment protected cardiomyocytes from hypoxia‐induced apoptosis and upregulated miR‐1290 and HIF1A, but downregulated HIF3A under hypoxia. The protective effect of AA was abolished by miR‐1290 knockdown, whereas enhanced by miR‐1290 overexpression. In addition, miR‐1290 knockdown increased HIF1A expression, but reduced HIF3A expression in cardiomyocytes. Dual luciferase assay confirmed miR‐1290 direct targeting the 3′ UTR of HIF3A. HIF3A overexpression counteracted the anti‐apoptosis effect of AA or miR‐1290. In conclusion, AA can protect cardiomyocytes against hypoxia‐induced apoptosis through regulating the miR‐1290/HIF3A/HIF‐1α axis, and miR‐1290 may be a potential target in the prevention of myocardial ischemia‐reperfusion injury. © 2017 IUBMB Life, 69(9):660–667, 2017" @default.
• W2726401904 created "2017-07-14" @default.
• W2726401904 creator A5004958903 @default.
• W2726401904 creator A5006913265 @default.
• W2726401904 creator A5025895957 @default.
• W2726401904 creator A5054579907 @default.
• W2726401904 creator A5055968386 @default.
• W2726401904 creator A5071115874 @default.
• W2726401904 creator A5078689160 @default.
• W2726401904 creator A5091070290 @default.
• W2726401904 date "2017-07-07" @default.
• W2726401904 modified "2023-10-16" @default.
• W2726401904 title "Asiatic acid enhances survival of human AC16 cardiomyocytes under hypoxia by upregulating miR‐1290" @default.
• W2726401904 cites W1969371558 @default.
• W2726401904 cites W1969530780 @default.
• W2726401904 cites W1969697394 @default.
• W2726401904 cites W1986979509 @default.
• W2726401904 cites W1994201257 @default.
• W2726401904 cites W1994649209 @default.
• W2726401904 cites W1995234317 @default.
• W2726401904 cites W1996463890 @default.
• W2726401904 cites W2013005819 @default.
• W2726401904 cites W2017064363 @default.
• W2726401904 cites W2022270707 @default.
• W2726401904 cites W2023172513 @default.
• W2726401904 cites W2027852965 @default.
• W2726401904 cites W2029875051 @default.
• W2726401904 cites W2042138655 @default.
• W2726401904 cites W2076286865 @default.
• W2726401904 cites W2086989758 @default.
• W2726401904 cites W2092050966 @default.
• W2726401904 cites W2093274908 @default.
• W2726401904 cites W2094550005 @default.
• W2726401904 cites W2097950056 @default.
• W2726401904 cites W2102365921 @default.
• W2726401904 cites W2102526923 @default.
• W2726401904 cites W2118085952 @default.
• W2726401904 cites W2121091450 @default.
• W2726401904 cites W2130006273 @default.
• W2726401904 cites W2131964970 @default.
• W2726401904 cites W2157607443 @default.
• W2726401904 cites W2159718273 @default.
• W2726401904 cites W2160448827 @default.
• W2726401904 cites W2160776618 @default.
• W2726401904 cites W2161277359 @default.
• W2726401904 cites W2173271872 @default.
• W2726401904 cites W2176136593 @default.
• W2726401904 cites W2293662671 @default.
• W2726401904 cites W2358732389 @default.
• W2726401904 cites W2509357277 @default.
• W2726401904 doi "https://doi.org/10.1002/iub.1648" @default.
• W2726401904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28686797" @default.
• W2726401904 hasPublicationYear "2017" @default.
• W2726401904 type Work @default.
• W2726401904 sameAs 2726401904 @default.
• W2726401904 citedByCount "23" @default.
• W2726401904 countsByYear W27264019042017 @default.
• W2726401904 countsByYear W27264019042018 @default.
• W2726401904 countsByYear W27264019042019 @default.
• W2726401904 countsByYear W27264019042020 @default.
• W2726401904 countsByYear W27264019042021 @default.
• W2726401904 countsByYear W27264019042022 @default.
• W2726401904 countsByYear W27264019042023 @default.
• W2726401904 crossrefType "journal-article" @default.
• W2726401904 hasAuthorship W2726401904A5004958903 @default.
• W2726401904 hasAuthorship W2726401904A5006913265 @default.
• W2726401904 hasAuthorship W2726401904A5025895957 @default.
• W2726401904 hasAuthorship W2726401904A5054579907 @default.
• W2726401904 hasAuthorship W2726401904A5055968386 @default.
• W2726401904 hasAuthorship W2726401904A5071115874 @default.
• W2726401904 hasAuthorship W2726401904A5078689160 @default.
• W2726401904 hasAuthorship W2726401904A5091070290 @default.
• W2726401904 hasBestOaLocation W27264019041 @default.
• W2726401904 hasConcept C104317684 @default.
• W2726401904 hasConcept C127561419 @default.
• W2726401904 hasConcept C173396325 @default.
• W2726401904 hasConcept C185592680 @default.
• W2726401904 hasConcept C190283241 @default.
• W2726401904 hasConcept C502942594 @default.
• W2726401904 hasConcept C54009773 @default.
• W2726401904 hasConcept C55493867 @default.
• W2726401904 hasConcept C86803240 @default.
• W2726401904 hasConcept C95444343 @default.
• W2726401904 hasConceptScore W2726401904C104317684 @default.
• W2726401904 hasConceptScore W2726401904C127561419 @default.
• W2726401904 hasConceptScore W2726401904C173396325 @default.
• W2726401904 hasConceptScore W2726401904C185592680 @default.
• W2726401904 hasConceptScore W2726401904C190283241 @default.
• W2726401904 hasConceptScore W2726401904C502942594 @default.
• W2726401904 hasConceptScore W2726401904C54009773 @default.
• W2726401904 hasConceptScore W2726401904C55493867 @default.
• W2726401904 hasConceptScore W2726401904C86803240 @default.
• W2726401904 hasConceptScore W2726401904C95444343 @default.
• W2726401904 hasIssue "9" @default.
• W2726401904 hasLocation W27264019041 @default.
• W2726401904 hasLocation W27264019042 @default.
• W2726401904 hasOpenAccess W2726401904 @default.
• W2726401904 hasPrimaryLocation W27264019041 @default.

• next