Matches in SemOpenAlex for { <https://semopenalex.org/work/W2726738066> ?p ?o ?g. }
- W2726738066 endingPage "e0179446" @default.
- W2726738066 startingPage "e0179446" @default.
- W2726738066 abstract "Epstein-Barr virus (EBV), human herpes virus 4, has been classically associated with infectious mononucleosis, multiple sclerosis and several types of cancers. Many of these diseases show marked geographical differences in prevalence, which points to underlying genetic and/or environmental factors. Those factors may include a different susceptibility to EBV infection and viral copy number among human populations. Since EBV is commonly used to transform B-cells into lymphoblastoid cell lines (LCLs) we hypothesize that differences in EBV copy number among individual LCLs may reflect differential susceptibility to EBV infection. To test this hypothesis, we retrieved whole-genome sequenced EBV-mapping reads from 1,753 LCL samples derived from 19 populations worldwide that were sequenced within the context of the 1000 Genomes Project. An in silico methodology was developed to estimate the number of EBV copy number in LCLs and validated these estimations by real-time PCR. After experimentally confirming that EBV relative copy number remains stable over cell passages, we performed a genome wide association analysis (GWAS) to try detecting genetic variants of the host that may be associated with EBV copy number. Our GWAS has yielded several genomic regions suggestively associated with the number of EBV genomes per cell in LCLs, unraveling promising candidate genes such as CAND1, a known inhibitor of EBV replication. While this GWAS does not unequivocally establish the degree to which genetic makeup of individuals determine viral levels within their derived LCLs, for which a larger sample size will be needed, it potentially highlighted human genes affecting EBV-related processes, which constitute interesting candidates to follow up in the context of EBV related pathologies." @default.
- W2726738066 created "2017-07-14" @default.
- W2726738066 creator A5058492717 @default.
- W2726738066 creator A5058496001 @default.
- W2726738066 creator A5058587051 @default.
- W2726738066 creator A5062328703 @default.
- W2726738066 creator A5063606139 @default.
- W2726738066 creator A5072502621 @default.
- W2726738066 creator A5074101623 @default.
- W2726738066 creator A5081361612 @default.
- W2726738066 creator A5085347075 @default.
- W2726738066 creator A5090906693 @default.
- W2726738066 date "2017-06-27" @default.
- W2726738066 modified "2023-10-15" @default.
- W2726738066 title "Genetic factors affecting EBV copy number in lymphoblastoid cell lines derived from the 1000 Genome Project samples" @default.
- W2726738066 cites W1531490664 @default.
- W2726738066 cites W1633031402 @default.
- W2726738066 cites W1787089416 @default.
- W2726738066 cites W1960544894 @default.
- W2726738066 cites W1967073403 @default.
- W2726738066 cites W1968819525 @default.
- W2726738066 cites W1980168725 @default.
- W2726738066 cites W1984636340 @default.
- W2726738066 cites W1985571905 @default.
- W2726738066 cites W1988031203 @default.
- W2726738066 cites W1988829747 @default.
- W2726738066 cites W1989733951 @default.
- W2726738066 cites W1990558411 @default.
- W2726738066 cites W1992127683 @default.
- W2726738066 cites W2003045938 @default.
- W2726738066 cites W2003283154 @default.
- W2726738066 cites W2004250561 @default.
- W2726738066 cites W2010345998 @default.
- W2726738066 cites W2012738522 @default.
- W2726738066 cites W2020237866 @default.
- W2726738066 cites W2031647166 @default.
- W2726738066 cites W2033151532 @default.
- W2726738066 cites W2034046719 @default.
- W2726738066 cites W2034623896 @default.
- W2726738066 cites W2036146366 @default.
- W2726738066 cites W2038963685 @default.
- W2726738066 cites W2046451999 @default.
- W2726738066 cites W2053361200 @default.
- W2726738066 cites W2055043387 @default.
- W2726738066 cites W2068568965 @default.
- W2726738066 cites W2071066251 @default.
- W2726738066 cites W2074924096 @default.
- W2726738066 cites W2078421579 @default.
- W2726738066 cites W2084345598 @default.
- W2726738066 cites W2085246986 @default.
- W2726738066 cites W2086320165 @default.
- W2726738066 cites W2099162702 @default.
- W2726738066 cites W2102164595 @default.
- W2726738066 cites W2103649136 @default.
- W2726738066 cites W2108234281 @default.
- W2726738066 cites W2109130469 @default.
- W2726738066 cites W2120228756 @default.
- W2726738066 cites W2123584222 @default.
- W2726738066 cites W2130584672 @default.
- W2726738066 cites W2137770315 @default.
- W2726738066 cites W2137996717 @default.
- W2726738066 cites W2140481064 @default.
- W2726738066 cites W2142473971 @default.
- W2726738066 cites W2143507493 @default.
- W2726738066 cites W2147377553 @default.
- W2726738066 cites W2152942628 @default.
- W2726738066 cites W2156924697 @default.
- W2726738066 cites W2157183541 @default.
- W2726738066 cites W2159377933 @default.
- W2726738066 cites W2161245845 @default.
- W2726738066 cites W2162098634 @default.
- W2726738066 cites W2163013660 @default.
- W2726738066 cites W2168133698 @default.
- W2726738066 cites W2169382766 @default.
- W2726738066 cites W2237741403 @default.
- W2726738066 cites W2239090104 @default.
- W2726738066 cites W2268072246 @default.
- W2726738066 cites W2310029373 @default.
- W2726738066 cites W2412215897 @default.
- W2726738066 doi "https://doi.org/10.1371/journal.pone.0179446" @default.
- W2726738066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5927406" @default.
- W2726738066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29709034" @default.
- W2726738066 hasPublicationYear "2017" @default.
- W2726738066 type Work @default.
- W2726738066 sameAs 2726738066 @default.
- W2726738066 citedByCount "23" @default.
- W2726738066 countsByYear W27267380662017 @default.
- W2726738066 countsByYear W27267380662018 @default.
- W2726738066 countsByYear W27267380662019 @default.
- W2726738066 countsByYear W27267380662020 @default.
- W2726738066 countsByYear W27267380662021 @default.
- W2726738066 countsByYear W27267380662022 @default.
- W2726738066 countsByYear W27267380662023 @default.
- W2726738066 crossrefType "journal-article" @default.
- W2726738066 hasAuthorship W2726738066A5058492717 @default.
- W2726738066 hasAuthorship W2726738066A5058496001 @default.
- W2726738066 hasAuthorship W2726738066A5058587051 @default.
- W2726738066 hasAuthorship W2726738066A5062328703 @default.