FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2726800033> ?p ?o ?g. }

• W2726800033 endingPage "e0179372" @default.
• W2726800033 startingPage "e0179372" @default.
• W2726800033 abstract "Understanding tumor heterogeneity is an urgent and unmet need in cancer research. In this study, we used a morphology-based optical cell separation process to classify a heterogeneous cancer cell population into characteristic subpopulations. To classify the cell subpopulations, we assessed their morphology in hydrogel, a three-dimensional culture environment that induces morphological changes according to the characteristics of the cells (i.e., growth, migration, and invasion). We encapsulated the murine breast cancer cell line 4T1E, as a heterogeneous population that includes highly metastatic cells, in click-crosslinkable and photodegradable gelatin hydrogels, which we developed previously. We observed morphological changes within 3 days of encapsulating the cells in the hydrogel. We separated the 4T1E cell population into colony- and granular-type cells by optical separation, in which local UV-induced degradation of the photodegradable hydrogel around the target cells enabled us to collect those cells. The obtained colony- and granular-type cells were evaluated in vitro by using a spheroid assay and in vivo by means of a tumor growth and metastasis assay. The spheroid assay showed that the colony-type cells formed compact spheroids in 2 days, whereas the granular-type cells did not form spheroids. The tumor growth assay in mice revealed that the granular-type cells exhibited lower tumor growth and a different metastasis behavior compared with the colony-type cells. These results suggest that morphology-based optical cell separation is a useful technique to classify a heterogeneous cancer cell population according to its cellular characteristics." @default.
• W2726800033 created "2017-07-14" @default.
• W2726800033 creator A5010729244 @default.
• W2726800033 creator A5012563387 @default.
• W2726800033 creator A5012785156 @default.
• W2726800033 creator A5034104055 @default.
• W2726800033 creator A5047511170 @default.
• W2726800033 creator A5047868880 @default.
• W2726800033 creator A5063401247 @default.
• W2726800033 creator A5086619153 @default.
• W2726800033 date "2017-06-30" @default.
• W2726800033 modified "2023-10-13" @default.
• W2726800033 title "Morphology-based optical separation of subpopulations from a heterogeneous murine breast cancer cell line" @default.
• W2726800033 cites W1967293289 @default.
• W2726800033 cites W1968107959 @default.
• W2726800033 cites W1971163936 @default.
• W2726800033 cites W1987012261 @default.
• W2726800033 cites W1988865098 @default.
• W2726800033 cites W2010251891 @default.
• W2726800033 cites W2035744072 @default.
• W2726800033 cites W2040621903 @default.
• W2726800033 cites W2056229778 @default.
• W2726800033 cites W2074705887 @default.
• W2726800033 cites W2083914261 @default.
• W2726800033 cites W2084943979 @default.
• W2726800033 cites W2112880601 @default.
• W2726800033 cites W2123303153 @default.
• W2726800033 cites W2133651123 @default.
• W2726800033 cites W2134208433 @default.
• W2726800033 cites W2135980516 @default.
• W2726800033 cites W2161656555 @default.
• W2726800033 cites W2220114634 @default.
• W2726800033 cites W2419356070 @default.
• W2726800033 cites W72067248 @default.
• W2726800033 cites W851309706 @default.
• W2726800033 cites W943412137 @default.
• W2726800033 doi "https://doi.org/10.1371/journal.pone.0179372" @default.
• W2726800033 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5493304" @default.
• W2726800033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28665963" @default.
• W2726800033 hasPublicationYear "2017" @default.
• W2726800033 type Work @default.
• W2726800033 sameAs 2726800033 @default.
• W2726800033 citedByCount "9" @default.
• W2726800033 countsByYear W27268000332018 @default.
• W2726800033 countsByYear W27268000332019 @default.
• W2726800033 countsByYear W27268000332020 @default.
• W2726800033 countsByYear W27268000332022 @default.
• W2726800033 countsByYear W27268000332023 @default.
• W2726800033 crossrefType "journal-article" @default.
• W2726800033 hasAuthorship W2726800033A5010729244 @default.
• W2726800033 hasAuthorship W2726800033A5012563387 @default.
• W2726800033 hasAuthorship W2726800033A5012785156 @default.
• W2726800033 hasAuthorship W2726800033A5034104055 @default.
• W2726800033 hasAuthorship W2726800033A5047511170 @default.
• W2726800033 hasAuthorship W2726800033A5047868880 @default.
• W2726800033 hasAuthorship W2726800033A5063401247 @default.
• W2726800033 hasAuthorship W2726800033A5086619153 @default.
• W2726800033 hasBestOaLocation W27268000331 @default.
• W2726800033 hasConcept C11957725 @default.
• W2726800033 hasConcept C121608353 @default.
• W2726800033 hasConcept C1491633281 @default.
• W2726800033 hasConcept C153911025 @default.
• W2726800033 hasConcept C175369904 @default.
• W2726800033 hasConcept C185592680 @default.
• W2726800033 hasConcept C189014844 @default.
• W2726800033 hasConcept C2779013556 @default.
• W2726800033 hasConcept C2908647359 @default.
• W2726800033 hasConcept C502942594 @default.
• W2726800033 hasConcept C54355233 @default.
• W2726800033 hasConcept C55493867 @default.
• W2726800033 hasConcept C71924100 @default.
• W2726800033 hasConcept C81885089 @default.
• W2726800033 hasConcept C86803240 @default.
• W2726800033 hasConcept C95444343 @default.
• W2726800033 hasConcept C96232424 @default.
• W2726800033 hasConcept C99454951 @default.
• W2726800033 hasConceptScore W2726800033C11957725 @default.
• W2726800033 hasConceptScore W2726800033C121608353 @default.
• W2726800033 hasConceptScore W2726800033C1491633281 @default.
• W2726800033 hasConceptScore W2726800033C153911025 @default.
• W2726800033 hasConceptScore W2726800033C175369904 @default.
• W2726800033 hasConceptScore W2726800033C185592680 @default.
• W2726800033 hasConceptScore W2726800033C189014844 @default.
• W2726800033 hasConceptScore W2726800033C2779013556 @default.
• W2726800033 hasConceptScore W2726800033C2908647359 @default.
• W2726800033 hasConceptScore W2726800033C502942594 @default.
• W2726800033 hasConceptScore W2726800033C54355233 @default.
• W2726800033 hasConceptScore W2726800033C55493867 @default.
• W2726800033 hasConceptScore W2726800033C71924100 @default.
• W2726800033 hasConceptScore W2726800033C81885089 @default.
• W2726800033 hasConceptScore W2726800033C86803240 @default.
• W2726800033 hasConceptScore W2726800033C95444343 @default.
• W2726800033 hasConceptScore W2726800033C96232424 @default.
• W2726800033 hasConceptScore W2726800033C99454951 @default.
• W2726800033 hasFunder F4320311405 @default.
• W2726800033 hasFunder F4320334764 @default.
• W2726800033 hasIssue "6" @default.
• W2726800033 hasLocation W27268000331 @default.

• next