Matches in SemOpenAlex for { <https://semopenalex.org/work/W2726859623> ?p ?o ?g. }
- W2726859623 endingPage "46" @default.
- W2726859623 startingPage "1" @default.
- W2726859623 abstract "G protein-coupled receptors (GPCRs) represent the largest and most physiologically important integral membrane protein family, and these receptors respond to a wide variety of physiological and environmental stimuli. GPCRs are among the most critical therapeutic targets for numerous human diseases, and approximately one-third of the currently marketed drugs target this receptor family. The recent breakthroughs in GPCR structural biology have significantly contributed to our understanding of GPCR function, ligand binding, and pharmacological action as well as to the design of new drugs. This perspective highlights the latest advances in GPCR structures with a focus on the receptor-ligand interactions of each receptor family in class A nonrhodopsin GPCRs as well as the structural features for their activation, biased signaling, and allosteric mechanisms. The current state-of-the-art methodologies of structure-based drug design (SBDD) approaches in the GPCR research field are also discussed." @default.
- W2726859623 created "2017-07-14" @default.
- W2726859623 creator A5016220974 @default.
- W2726859623 creator A5042122089 @default.
- W2726859623 creator A5055306211 @default.
- W2726859623 date "2017-07-21" @default.
- W2726859623 modified "2023-10-17" @default.
- W2726859623 title "Recent Advances in Structure-Based Drug Design Targeting Class A G Protein-Coupled Receptors Utilizing Crystal Structures and Computational Simulations" @default.
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