Matches in SemOpenAlex for { <https://semopenalex.org/work/W2726965062> ?p ?o ?g. }
- W2726965062 endingPage "e0180026" @default.
- W2726965062 startingPage "e0180026" @default.
- W2726965062 abstract "The Polycomb group (PcG) proteins have been implicated in epigenetic transcriptional repression in development, stem cell maintenance and in cancer. The chromodomain protein Polycomb (Pc) is a key member of the PcG. Pc binds to the histone mark, trimethylated histone 3 lysine 27 (H3K27me3), to initiate transcriptional repression. How PcG proteins are recruited to target loci is not fully understood. Here we show that the Drosophila SERTA domain protein Taranis (Tara) is involved in transcriptional regulation of Pc target genes. Embryos lacking Tara exhibit a partial homeotic transformation of cuticular the segments, a phenotype associated with the loss of Pc function. Moreover, Drosophila embryos homozygous for a tara hypomorphic allele also misexpress engrailed, a Pc-regulated gene, and this phenotype is associated with the loss of Pc binding to the cis response element in the engrailed enhancer. In relation to that, Pc recruitment is reduced on the salivary gland polytene chromosomes and specifically at the engrailed locus. These results suggest that Tara might be required for positioning Pc to a subset of its target genes." @default.
- W2726965062 created "2017-07-14" @default.
- W2726965062 creator A5034990537 @default.
- W2726965062 creator A5059403398 @default.
- W2726965062 date "2017-06-30" @default.
- W2726965062 modified "2023-09-24" @default.
- W2726965062 title "The SERTAD protein Taranis plays a role in Polycomb-mediated gene repression" @default.
- W2726965062 cites W1737310840 @default.
- W2726965062 cites W1819071048 @default.
- W2726965062 cites W1823770435 @default.
- W2726965062 cites W1832882893 @default.
- W2726965062 cites W1848239018 @default.
- W2726965062 cites W1855977133 @default.
- W2726965062 cites W1895544505 @default.
- W2726965062 cites W1898469708 @default.
- W2726965062 cites W1956344811 @default.
- W2726965062 cites W1963601589 @default.
- W2726965062 cites W1966015758 @default.
- W2726965062 cites W1967381498 @default.
- W2726965062 cites W1969851123 @default.
- W2726965062 cites W1970709003 @default.
- W2726965062 cites W1974916823 @default.
- W2726965062 cites W1978867225 @default.
- W2726965062 cites W1979635179 @default.
- W2726965062 cites W1980132133 @default.
- W2726965062 cites W1980378834 @default.
- W2726965062 cites W1985361814 @default.
- W2726965062 cites W2015100891 @default.
- W2726965062 cites W2015132841 @default.
- W2726965062 cites W2021104747 @default.
- W2726965062 cites W2044627216 @default.
- W2726965062 cites W2046683892 @default.
- W2726965062 cites W2050208964 @default.
- W2726965062 cites W2052837845 @default.
- W2726965062 cites W2053352747 @default.
- W2726965062 cites W2071516298 @default.
- W2726965062 cites W2073869073 @default.
- W2726965062 cites W2074794333 @default.
- W2726965062 cites W2079315297 @default.
- W2726965062 cites W2080933801 @default.
- W2726965062 cites W2089356924 @default.
- W2726965062 cites W2090017665 @default.
- W2726965062 cites W2091151146 @default.
- W2726965062 cites W2096383671 @default.
- W2726965062 cites W2098572478 @default.
- W2726965062 cites W2111012767 @default.
- W2726965062 cites W2115467757 @default.
- W2726965062 cites W2121893023 @default.
- W2726965062 cites W2126740737 @default.
- W2726965062 cites W2128624858 @default.
- W2726965062 cites W2151424225 @default.
- W2726965062 cites W2169719363 @default.
- W2726965062 cites W2171172006 @default.
- W2726965062 cites W2176692887 @default.
- W2726965062 cites W2346128454 @default.
- W2726965062 cites W2473302527 @default.
- W2726965062 cites W277026245 @default.
- W2726965062 cites W4212815241 @default.
- W2726965062 doi "https://doi.org/10.1371/journal.pone.0180026" @default.
- W2726965062 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5493352" @default.
- W2726965062 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28665982" @default.
- W2726965062 hasPublicationYear "2017" @default.
- W2726965062 type Work @default.
- W2726965062 sameAs 2726965062 @default.
- W2726965062 citedByCount "5" @default.
- W2726965062 countsByYear W27269650622018 @default.
- W2726965062 countsByYear W27269650622020 @default.
- W2726965062 countsByYear W27269650622021 @default.
- W2726965062 countsByYear W27269650622023 @default.
- W2726965062 crossrefType "journal-article" @default.
- W2726965062 hasAuthorship W2726965062A5034990537 @default.
- W2726965062 hasAuthorship W2726965062A5059403398 @default.
- W2726965062 hasBestOaLocation W27269650621 @default.
- W2726965062 hasConcept C104317684 @default.
- W2726965062 hasConcept C111936080 @default.
- W2726965062 hasConcept C121587040 @default.
- W2726965062 hasConcept C127716648 @default.
- W2726965062 hasConcept C150194340 @default.
- W2726965062 hasConcept C158448853 @default.
- W2726965062 hasConcept C161223559 @default.
- W2726965062 hasConcept C165864922 @default.
- W2726965062 hasConcept C179138559 @default.
- W2726965062 hasConcept C186310378 @default.
- W2726965062 hasConcept C2776745794 @default.
- W2726965062 hasConcept C2777116130 @default.
- W2726965062 hasConcept C41091548 @default.
- W2726965062 hasConcept C46751350 @default.
- W2726965062 hasConcept C54355233 @default.
- W2726965062 hasConcept C64632358 @default.
- W2726965062 hasConcept C64927066 @default.
- W2726965062 hasConcept C67705224 @default.
- W2726965062 hasConcept C83640560 @default.
- W2726965062 hasConcept C86339819 @default.
- W2726965062 hasConcept C86803240 @default.
- W2726965062 hasConceptScore W2726965062C104317684 @default.
- W2726965062 hasConceptScore W2726965062C111936080 @default.
- W2726965062 hasConceptScore W2726965062C121587040 @default.
- W2726965062 hasConceptScore W2726965062C127716648 @default.