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• W2727378930 abstract "// Hidenobu Ishii 1 , Koichi Azuma 1 , Akihiko Kawahara 2 , Norikazu Matsuo 1 , Takaaki Tokito 1 , Takashi Kinoshita 1 , Kazuhiko Yamada 1 , Tetsuro Sasada 3 , Jun Akiba 2 and Tomoaki Hoshino 1 1 Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Japan 2 Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan 3 Cancer Vaccine Center, Kanagawa Cancer Center Research Institute, Yokohama, Japan Correspondence to: Koichi Azuma, email: azuma@med.kurume-u.ac.jp Keywords: non-small cell lung cancer, programmed cell death-ligand 1, immunoscore, tumor-infiltrating lymphocyte, adjuvant chemotherapy Received: March 13, 2017      Accepted: May 22, 2017      Published: June 27, 2017 ABSTRACT Programmed cell death 1 (PD-1) receptor–ligand interaction is a major pathway that is often hijacked by tumors to suppress immune control. Immunoscore (IS), a combinational index of CD3 and CD8 tumor-infiltrating lymphocyte (TIL) density in the tumor’s center and invasive margin, is a new prognostic tool suggested to be superior to conventional tumor-staging methods in various tumors. This retrospective study aimed to investigate the prevalence and prognostic roles of PD-ligand 1 (PD-L1) expression and IS in non-small cell lung cancer (NSCLC) patients receiving adjuvant chemotherapy. PD-L1 expression and TIL density were evaluated by immunohistochemical analysis in 36 patients with stage II and III NSCLC. Tumors with staining in over 1% of their cells were scored as positive for PD-L1 expression, and we determined the median number of CD3- and CD8-positive TILs as the cutoff point for TIL density. To determine IS, each patient was given a binary score (0 for low and 1 for high) for CD3 and CD8 density in both the tumor center and invasive margin region. PD-L1 expression in tumor cells was observed in 61.1% (22/36) of patients. PD-L1 expression was significantly associated with high IS, and highest IS tended to have a favorable disease-free survival." @default.
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• W2727378930 date "2017-06-27" @default.
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• W2727378930 title "Programmed cell death-ligand 1 expression and immunoscore in stage II and III non-small cell lung cancer patients receiving adjuvant chemotherapy" @default.
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• W2727378930 doi "https://doi.org/10.18632/oncotarget.18651" @default.
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