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- W2727570125 abstract "Abstract Twenty novel 2 - thioxo - 1 , 3 - thiazolidin - 4 - one derivatives ( 5a - 5t ) were synthesized and evaluated for their antitubercular activity. The structure of the compounds was confirmed by IR, NMR and Mass Spectroscopy methods. In addition, single-crystal X-ray diffraction was performed for compound 5a . All the synthesized compounds were screened for their in - vitro antimycobacterial activity against MTB (H37RV, ATCC No: 27294) by Alamar Blue assay method. Compounds 5r , 5k , 5t displayed most potent in - vitro activity with MICs of 0.05, 0.1, 0.2 μg/ml concentrations respectively which are comparatively potent than the standards. Molecular docking and dynamics simulations were performed to find out the plausible mechanism of the titled compounds." @default.
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- W2727570125 date "2017-11-01" @default.
- W2727570125 modified "2023-10-10" @default.
- W2727570125 title "Molecular modeling of drug-pathophysiological Mtb protein targets: Synthesis of some 2-thioxo-1, 3-thiazolidin-4-one derivatives as anti-tubercular agents" @default.
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- W2727570125 doi "https://doi.org/10.1016/j.molstruc.2017.07.009" @default.
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