Matches in SemOpenAlex for { <https://semopenalex.org/work/W2727623094> ?p ?o ?g. }
- W2727623094 endingPage "1740" @default.
- W2727623094 startingPage "1730" @default.
- W2727623094 abstract "Circulating miRNAs have shown great promises as noninvasive diagnostic and predictive biomarkers in several solid tumors. While the miRNA profiles of renal tumors have been extensively explored, knowledge of their circulating counterparts is limited. Our study aimed to provide a large‐scale genome‐wide profiling of plasma circulating miRNA in clear‐cell renal cell carcinoma (ccRCC). Plasma samples from 94 ccRCC cases and 100 controls were screened for 754 circulating micro‐RNAs (miRNA) by TaqMan arrays. Analyses including known risk factors for renal cancer—namely, age, sex, hypertension, obesity, diabetes, tobacco smoking and alcohol consumption—highlighted that circulating miRNA profiles were tightly correlated with the stage of the disease. Advanced tumors, characterized as stage III and IV, were associated with specific miRNA signatures that significantly differ from both controls and earlier stage ccRCC cases. Molecular pathway enrichment analyses of their gene targets showed high similarities with alterations observed in renal tumors. Plasma circulating levels of miR‐150 were significantly associated with RCC‐specific survival and could marginally improve the predictive accuracy of clinical parameters in our series, including age at diagnosis, sex and conventional staging. In summary, our results suggest that circulating miRNAs may provide insights into renal cell carcinoma progression." @default.
- W2727623094 created "2017-07-14" @default.
- W2727623094 creator A5001258652 @default.
- W2727623094 creator A5001857260 @default.
- W2727623094 creator A5024933419 @default.
- W2727623094 creator A5029786218 @default.
- W2727623094 creator A5041110787 @default.
- W2727623094 creator A5041823487 @default.
- W2727623094 creator A5046671345 @default.
- W2727623094 creator A5078525701 @default.
- W2727623094 creator A5084335401 @default.
- W2727623094 date "2017-07-07" @default.
- W2727623094 modified "2023-09-30" @default.
- W2727623094 title "Large-scale genome-wide screening of circulating microRNAs in clear cell renal cell carcinoma reveals specific signatures in late-stage disease" @default.
- W2727623094 cites W1546547645 @default.
- W2727623094 cites W1759375471 @default.
- W2727623094 cites W1829246941 @default.
- W2727623094 cites W1915855266 @default.
- W2727623094 cites W1965296962 @default.
- W2727623094 cites W1965836252 @default.
- W2727623094 cites W1972644344 @default.
- W2727623094 cites W1975151676 @default.
- W2727623094 cites W1975776107 @default.
- W2727623094 cites W1982864698 @default.
- W2727623094 cites W1983986272 @default.
- W2727623094 cites W1985458442 @default.
- W2727623094 cites W1988333927 @default.
- W2727623094 cites W2021485215 @default.
- W2727623094 cites W2023642368 @default.
- W2727623094 cites W2041881143 @default.
- W2727623094 cites W2047639024 @default.
- W2727623094 cites W2053277483 @default.
- W2727623094 cites W2064292948 @default.
- W2727623094 cites W2073731809 @default.
- W2727623094 cites W2074689365 @default.
- W2727623094 cites W2074820129 @default.
- W2727623094 cites W2083930144 @default.
- W2727623094 cites W2084453192 @default.
- W2727623094 cites W2084872607 @default.
- W2727623094 cites W2088450666 @default.
- W2727623094 cites W2090629367 @default.
- W2727623094 cites W2107860084 @default.
- W2727623094 cites W2109350483 @default.
- W2727623094 cites W2111306860 @default.
- W2727623094 cites W2111471857 @default.
- W2727623094 cites W2115093090 @default.
- W2727623094 cites W2128270520 @default.
- W2727623094 cites W2129925362 @default.
- W2727623094 cites W2133658633 @default.
- W2727623094 cites W2140775205 @default.
- W2727623094 cites W2152694160 @default.
- W2727623094 cites W2157793936 @default.
- W2727623094 cites W2166763675 @default.
- W2727623094 cites W2252881723 @default.
- W2727623094 cites W2261694353 @default.
- W2727623094 cites W2284518822 @default.
- W2727623094 cites W2335012284 @default.
- W2727623094 cites W2342313929 @default.
- W2727623094 cites W266360251 @default.
- W2727623094 cites W32204808 @default.
- W2727623094 cites W4294216483 @default.
- W2727623094 doi "https://doi.org/10.1002/ijc.30845" @default.
- W2727623094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28639257" @default.
- W2727623094 hasPublicationYear "2017" @default.
- W2727623094 type Work @default.
- W2727623094 sameAs 2727623094 @default.
- W2727623094 citedByCount "27" @default.
- W2727623094 countsByYear W27276230942017 @default.
- W2727623094 countsByYear W27276230942018 @default.
- W2727623094 countsByYear W27276230942019 @default.
- W2727623094 countsByYear W27276230942020 @default.
- W2727623094 countsByYear W27276230942021 @default.
- W2727623094 countsByYear W27276230942022 @default.
- W2727623094 countsByYear W27276230942023 @default.
- W2727623094 crossrefType "journal-article" @default.
- W2727623094 hasAuthorship W2727623094A5001258652 @default.
- W2727623094 hasAuthorship W2727623094A5001857260 @default.
- W2727623094 hasAuthorship W2727623094A5024933419 @default.
- W2727623094 hasAuthorship W2727623094A5029786218 @default.
- W2727623094 hasAuthorship W2727623094A5041110787 @default.
- W2727623094 hasAuthorship W2727623094A5041823487 @default.
- W2727623094 hasAuthorship W2727623094A5046671345 @default.
- W2727623094 hasAuthorship W2727623094A5078525701 @default.
- W2727623094 hasAuthorship W2727623094A5084335401 @default.
- W2727623094 hasBestOaLocation W27276230941 @default.
- W2727623094 hasConcept C104317684 @default.
- W2727623094 hasConcept C121608353 @default.
- W2727623094 hasConcept C126322002 @default.
- W2727623094 hasConcept C143998085 @default.
- W2727623094 hasConcept C145059251 @default.
- W2727623094 hasConcept C146357865 @default.
- W2727623094 hasConcept C151730666 @default.
- W2727623094 hasConcept C2777472916 @default.
- W2727623094 hasConcept C2779134260 @default.
- W2727623094 hasConcept C2781068499 @default.
- W2727623094 hasConcept C2781278892 @default.
- W2727623094 hasConcept C502942594 @default.
- W2727623094 hasConcept C54355233 @default.