Matches in SemOpenAlex for { <https://semopenalex.org/work/W2727793071> ?p ?o ?g. }
- W2727793071 endingPage "197.e3" @default.
- W2727793071 startingPage "185" @default.
- W2727793071 abstract "Dietary excess triggers accumulation of pro-inflammatory microglia in the mediobasal hypothalamus (MBH), but the components of this microgliosis and its metabolic consequences remain uncertain. Here, we show that microglial inflammatory signaling determines the immunologic response of the MBH to dietary excess and regulates hypothalamic control of energy homeostasis in mice. Either pharmacologically depleting microglia or selectively restraining microglial NF-κB-dependent signaling sharply reduced microgliosis, an effect that includes prevention of MBH entry by bone-marrow-derived myeloid cells, and greatly limited diet-induced hyperphagia and weight gain. Conversely, forcing microglial activation through cell-specific deletion of the negative NF-κB regulator A20 induced spontaneous MBH microgliosis and cellular infiltration, reduced energy expenditure, and increased both food intake and weight gain even in absence of a dietary challenge. Thus, microglial inflammatory activation, stimulated by dietary excess, orchestrates a multicellular hypothalamic response that mediates obesity susceptibility, providing a mechanistic rationale for non-neuronal approaches to treat metabolic diseases." @default.
- W2727793071 created "2017-07-14" @default.
- W2727793071 creator A5021482790 @default.
- W2727793071 creator A5027970945 @default.
- W2727793071 creator A5030716166 @default.
- W2727793071 creator A5036651616 @default.
- W2727793071 creator A5041070834 @default.
- W2727793071 creator A5063521416 @default.
- W2727793071 creator A5073179411 @default.
- W2727793071 creator A5073647620 @default.
- W2727793071 creator A5074846328 @default.
- W2727793071 creator A5077743947 @default.
- W2727793071 creator A5090500596 @default.
- W2727793071 date "2017-07-01" @default.
- W2727793071 modified "2023-10-16" @default.
- W2727793071 title "Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility" @default.
- W2727793071 cites W1511961767 @default.
- W2727793071 cites W1537809359 @default.
- W2727793071 cites W1541159186 @default.
- W2727793071 cites W1561443084 @default.
- W2727793071 cites W1590854724 @default.
- W2727793071 cites W1948478725 @default.
- W2727793071 cites W1965569135 @default.
- W2727793071 cites W1968994158 @default.
- W2727793071 cites W1972262497 @default.
- W2727793071 cites W1991401793 @default.
- W2727793071 cites W1991868611 @default.
- W2727793071 cites W2008915266 @default.
- W2727793071 cites W2009762469 @default.
- W2727793071 cites W2019604999 @default.
- W2727793071 cites W2020781390 @default.
- W2727793071 cites W2025131475 @default.
- W2727793071 cites W2029906813 @default.
- W2727793071 cites W2035313241 @default.
- W2727793071 cites W2042187887 @default.
- W2727793071 cites W2044699444 @default.
- W2727793071 cites W2047021244 @default.
- W2727793071 cites W2052184532 @default.
- W2727793071 cites W2064656234 @default.
- W2727793071 cites W2068597583 @default.
- W2727793071 cites W2075792687 @default.
- W2727793071 cites W2077033935 @default.
- W2727793071 cites W2085158900 @default.
- W2727793071 cites W2088301466 @default.
- W2727793071 cites W2088666203 @default.
- W2727793071 cites W2096500024 @default.
- W2727793071 cites W2104003768 @default.
- W2727793071 cites W2104431737 @default.
- W2727793071 cites W2119656827 @default.
- W2727793071 cites W2124836944 @default.
- W2727793071 cites W2127491778 @default.
- W2727793071 cites W2128395587 @default.
- W2727793071 cites W2130495917 @default.
- W2727793071 cites W2131686384 @default.
- W2727793071 cites W2135808088 @default.
- W2727793071 cites W2135833206 @default.
- W2727793071 cites W2148898943 @default.
- W2727793071 cites W2154696002 @default.
- W2727793071 cites W2155702815 @default.
- W2727793071 cites W2160447524 @default.
- W2727793071 cites W2161057248 @default.
- W2727793071 cites W2165601025 @default.
- W2727793071 cites W2180449164 @default.
- W2727793071 cites W2280077905 @default.
- W2727793071 cites W2345745180 @default.
- W2727793071 cites W2357991904 @default.
- W2727793071 cites W2465638754 @default.
- W2727793071 cites W2511658934 @default.
- W2727793071 cites W2558045643 @default.
- W2727793071 cites W2564256804 @default.
- W2727793071 cites W2581154578 @default.
- W2727793071 cites W2604235446 @default.
- W2727793071 cites W302891049 @default.
- W2727793071 cites W337374803 @default.
- W2727793071 doi "https://doi.org/10.1016/j.cmet.2017.05.015" @default.
- W2727793071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5569901" @default.
- W2727793071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29874568" @default.
- W2727793071 hasPublicationYear "2017" @default.
- W2727793071 type Work @default.
- W2727793071 sameAs 2727793071 @default.
- W2727793071 citedByCount "288" @default.
- W2727793071 countsByYear W27277930712017 @default.
- W2727793071 countsByYear W27277930712018 @default.
- W2727793071 countsByYear W27277930712019 @default.
- W2727793071 countsByYear W27277930712020 @default.
- W2727793071 countsByYear W27277930712021 @default.
- W2727793071 countsByYear W27277930712022 @default.
- W2727793071 countsByYear W27277930712023 @default.
- W2727793071 crossrefType "journal-article" @default.
- W2727793071 hasAuthorship W2727793071A5021482790 @default.
- W2727793071 hasAuthorship W2727793071A5027970945 @default.
- W2727793071 hasAuthorship W2727793071A5030716166 @default.
- W2727793071 hasAuthorship W2727793071A5036651616 @default.
- W2727793071 hasAuthorship W2727793071A5041070834 @default.
- W2727793071 hasAuthorship W2727793071A5063521416 @default.
- W2727793071 hasAuthorship W2727793071A5073179411 @default.
- W2727793071 hasAuthorship W2727793071A5073647620 @default.
- W2727793071 hasAuthorship W2727793071A5074846328 @default.