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• W2727795877 abstract "Abstract Objective Serum amyloid A (SAA) is a non‐specific acute phase reaction protein that shows much higher levels in patients with cancer than in healthy individuals. The present study was designed to investigate the correlation of SAA level with overall survival (OS) and radiation pneumonitis (RP) in non‐small cell lung cancer patients receiving thoracic radiotherapy. Methods Patients with locally advanced non‐small cell lung cancer receiving thoracic radiotherapy or concurrent chemoradiotherapy were eligible for the study. Plasma samples were collected before radiotherapy (baseline), 2 and 4 weeks during radiotherapy, and at 3 months after the end of radiotherapy. The incidence of RP was recorded 1 year after radiotherapy. OS was defined as the interval between the date of treatment initiation and the date of death or last follow up if the patients were still alive. spss 18.0 and GraphPad Prism 5.0 software were used for statistical analyses, and P ≤ 0.05 was considered significant. Results In total, data from 114 patients were used for the final analyses. The median baseline SAA level was 101.4 μg/mL; patients with lower baseline SAA levels had a longer OS than those with a higher SAA level (25.8 vs 14.3 months, χ 2 = 5.519, P = 0.019). In multivariate analysis, sex, radiation dose, and baseline SAA level were independent prognostic factors. The SAA level after radiotherapy was significantly lower than that at baseline (142.6 vs 420.1 μg/mL, t = 3.50, P = 0.001). The average SAA level in patients with grade 2 or higher and less than grade 2 RP after radiotherapy was 476.7 μg/mL and 113.0 μg/mL, respectively, t = 2.72, P = 0.009. Conclusions SAA level might be a predictive biomarker for RP and OS in patients with locally advanced non‐small cell lung cancer receiving thoracic radiotherapy." @default.
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• W2727795877 date "2017-06-01" @default.
• W2727795877 modified "2023-10-16" @default.
• W2727795877 title "Study on the correlation of serum amyloid A level with overall survival and radiation pneumonitis in non-small cell lung cancer patients receiving thoracic radiotherapy" @default.
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• W2727795877 doi "https://doi.org/10.1002/pro6.20" @default.
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