FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2728132464> ?p ?o ?g. }

• W2728132464 endingPage "3631" @default.
• W2728132464 startingPage "3631" @default.
• W2728132464 abstract "Abstract Background: No prospective data are available about the efficacy of deferasirox versus deferiprone and desferrioxamine in monotherapy. Our study aimed to prospectively assess the efficacy of deferasirox versus deferiprone and desferrioxamine in monotherapy in a large cohort of thalassemia major (TM) patients by quantitative Magnetic Resonance (MR). Methods: Among the 2551 TM patients enrolled in the MIOT (Myocardial Iron Overload in Thalassemia) network we selected those with an MR follow up study at 18±3 months who had been received one chelator alone between the 2 MR scans. We identified three groups of patients: 235 treated with DFX, 142 with DFP and 162 with DFO. Iron overload was measured by T2* multiecho technique. Liver T2* values were converted into liver iron concentration (LIC) values. Biventricular function parameters were quantitatively evaluated by cine images. Results: Excellent/good levels of compliance were similar in the DFX (98.7%) vs DFP (96.3%) and DFO (97.5%) groups. Among the patients with myocardial iron overload at baseline, in all three groups there was a significant improvement in the global heart T2* value (DFX: +4.58±5.91ms P<0.0001, DFP: 8.53±6.97ms P<0.0001 and DFO: +3.93±5.21 ms P<0.0001) and a reduction in the number of pathological segments (DFX: -4.49±4.55 P<0.0001, DFP: -8.08±5.5.84 ms P=0.001 and DFO: -3.65±3.81 ms P<0.0001). In DFP and in DFO groups there was a significant improvement in left ventricular ejection function (LVEF) (+4.86±6.99% P=0.044 and +3.87±7.48% P=0.004, respectively). Only in the DFP group there was a significant improvement in right ventricular ejection function (RVEF) (6.69±4.61% P=0.001). The improvement in the global heart T2* was significantly lower in the DFX versus the DFP group , but it was not significantly different in the DFX versus the DFO group (Figure 1). The improvement in the LVEF was significantly higher in both DFP and DFO groups than in the DFX group while the improvement in the RVEF was significantly higher in the DFP than in DFX group (Figure 2). Among the patients with hepatic iron at baseline (LIC≥3mg/g dw) the changes were not significantly different in DFX versus the other groups. Conclusions: Prospectively in a large clinical setting of TM patients, DFX monotherapy was significantly less effective than DFP in improving myocardial siderosis and biventricular function and it was significantly less effective than DFO in improving the LVEF. Figure 1 Figure 1. Figure 2 Figure 2. Disclosures Pepe: Chiesi Farmaceutici and ApoPharma Inc.: Other: Alessia Pepe is the PI of the MIOT project, that receives no profit support from Chiesi Farmaceutici S.p.A. and ApoPharma Inc.." @default.
• W2728132464 created "2017-07-14" @default.
• W2728132464 creator A5000905151 @default.
• W2728132464 creator A5002668943 @default.
• W2728132464 creator A5010444302 @default.
• W2728132464 creator A5014591808 @default.
• W2728132464 creator A5016528606 @default.
• W2728132464 creator A5025860412 @default.
• W2728132464 creator A5038863342 @default.
• W2728132464 creator A5048158616 @default.
• W2728132464 creator A5062868786 @default.
• W2728132464 creator A5065749748 @default.
• W2728132464 creator A5076624687 @default.
• W2728132464 creator A5090278333 @default.
• W2728132464 creator A5090506270 @default.
• W2728132464 date "2016-12-02" @default.
• W2728132464 modified "2023-09-26" @default.
• W2728132464 title "A MRI Prospective Survey on Heart and Liver Iron and Cardiac Function in Thalassemia Major Patients Treated with Deferasirox Versus Deferiprone and Desferrioxamine in Monotherapy" @default.
• W2728132464 doi "https://doi.org/10.1182/blood.v128.22.3631.3631" @default.
• W2728132464 hasPublicationYear "2016" @default.
• W2728132464 type Work @default.
• W2728132464 sameAs 2728132464 @default.
• W2728132464 citedByCount "0" @default.
• W2728132464 crossrefType "journal-article" @default.
• W2728132464 hasAuthorship W2728132464A5000905151 @default.
• W2728132464 hasAuthorship W2728132464A5002668943 @default.
• W2728132464 hasAuthorship W2728132464A5010444302 @default.
• W2728132464 hasAuthorship W2728132464A5014591808 @default.
• W2728132464 hasAuthorship W2728132464A5016528606 @default.
• W2728132464 hasAuthorship W2728132464A5025860412 @default.
• W2728132464 hasAuthorship W2728132464A5038863342 @default.
• W2728132464 hasAuthorship W2728132464A5048158616 @default.
• W2728132464 hasAuthorship W2728132464A5062868786 @default.
• W2728132464 hasAuthorship W2728132464A5065749748 @default.
• W2728132464 hasAuthorship W2728132464A5076624687 @default.
• W2728132464 hasAuthorship W2728132464A5090278333 @default.
• W2728132464 hasAuthorship W2728132464A5090506270 @default.
• W2728132464 hasConcept C111566952 @default.
• W2728132464 hasConcept C126322002 @default.
• W2728132464 hasConcept C126838900 @default.
• W2728132464 hasConcept C143409427 @default.
• W2728132464 hasConcept C188816634 @default.
• W2728132464 hasConcept C2776517179 @default.
• W2728132464 hasConcept C2776672577 @default.
• W2728132464 hasConcept C2777799968 @default.
• W2728132464 hasConcept C2778198053 @default.
• W2728132464 hasConcept C2780883591 @default.
• W2728132464 hasConcept C2781053155 @default.
• W2728132464 hasConcept C71924100 @default.
• W2728132464 hasConcept C78085059 @default.
• W2728132464 hasConcept C90924648 @default.
• W2728132464 hasConceptScore W2728132464C111566952 @default.
• W2728132464 hasConceptScore W2728132464C126322002 @default.
• W2728132464 hasConceptScore W2728132464C126838900 @default.
• W2728132464 hasConceptScore W2728132464C143409427 @default.
• W2728132464 hasConceptScore W2728132464C188816634 @default.
• W2728132464 hasConceptScore W2728132464C2776517179 @default.
• W2728132464 hasConceptScore W2728132464C2776672577 @default.
• W2728132464 hasConceptScore W2728132464C2777799968 @default.
• W2728132464 hasConceptScore W2728132464C2778198053 @default.
• W2728132464 hasConceptScore W2728132464C2780883591 @default.
• W2728132464 hasConceptScore W2728132464C2781053155 @default.
• W2728132464 hasConceptScore W2728132464C71924100 @default.
• W2728132464 hasConceptScore W2728132464C78085059 @default.
• W2728132464 hasConceptScore W2728132464C90924648 @default.
• W2728132464 hasIssue "22" @default.
• W2728132464 hasLocation W27281324641 @default.
• W2728132464 hasOpenAccess W2728132464 @default.
• W2728132464 hasPrimaryLocation W27281324641 @default.
• W2728132464 hasRelatedWork W1561525732 @default.
• W2728132464 hasRelatedWork W1978568446 @default.
• W2728132464 hasRelatedWork W2060745758 @default.
• W2728132464 hasRelatedWork W2139644127 @default.
• W2728132464 hasRelatedWork W2147296656 @default.
• W2728132464 hasRelatedWork W2521084408 @default.
• W2728132464 hasRelatedWork W2554014150 @default.
• W2728132464 hasRelatedWork W2589509998 @default.
• W2728132464 hasRelatedWork W2911279459 @default.
• W2728132464 hasRelatedWork W2979886503 @default.
• W2728132464 hasRelatedWork W3014367854 @default.
• W2728132464 hasRelatedWork W3015021802 @default.
• W2728132464 hasRelatedWork W3021055709 @default.
• W2728132464 hasRelatedWork W3091753717 @default.
• W2728132464 hasVolume "128" @default.
• W2728132464 isParatext "false" @default.
• W2728132464 isRetracted "false" @default.
• W2728132464 magId "2728132464" @default.
• W2728132464 workType "article" @default.