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- W272822664 abstract "为了研究慢性粒细胞白血病(CML)慢性期患者应用干扰素-α(IFN-α)治疗后细胞遗传学疗效及其影响预后的因素,对我院10年来128例CML慢性期患者单用IFN-α或联用化疗药物后细胞遗传学变化、核型演变及与临床有关特征的关系进行了回顾性分析.核型分析全部应用G-显带,部分联合应用荧光染色体原位杂交技术检测.结果表明:①所有患者均获血液学缓解.②118例Ph染色体标准易位患者中36例(30.8%)获细胞遗传学反应,其中20例(17.1%)Ph染色体仍＞35%,13例(11.1%)Ph染色体＜35%,3例(2.5%)Ph染色体为0,达完全细胞遗传学缓解,细胞遗传学有效应者共16例(13.6%).③7例复杂变异易位患者中4例获细胞遗传学反应,其中2例(14.3%)Ph染色体＞35%,2例(14.3%)Ph染色体＜35%,无1例Ph染色体为0;3例简单变异易位患者无1例获细胞遗传学疗效.④IFN-α治疗后影响细胞遗传学疗效的因素有:性别、初诊病情、IFN-α是否联用其他化疗药物及是否持续治疗.⑤IFN-α治疗并不能防止CML疾病进展.结论:①每周IFN-α 600-900万U单用或联合Bu/Hu可使11.1%的标准易位和少数复杂变异易位Ph+CML患者获主要细胞遗传学效应,但不能防止疾病进展;②Ph变异易位并不预示IFN-α疗效不佳;③细胞遗传学监测有益于反映疗效与疾病进展,应定期监测." @default.
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- W272822664 date "2003-01-01" @default.
- W272822664 modified "2023-09-25" @default.
- W272822664 title "干扰素—α治疗Ph^＋慢性粒细胞白血病的细胞遗传学反应分析" @default.
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