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- W2728395985 abstract "Breathing uniquely engages permanent rhythmic contractions of skeletal muscles in a bilaterally synchronized manner. The executive control of respiration imparts on sets of brainstem interneurons synaptically assembled into an ordered network: the respiratory central pattern generator (CPG). We investigate the relationship of defined neuronal subtypes to the organizational logic of the respiratory CPG. We have previously demonstrated that neural progenitors expressing the homeobox gene Dbx1 give rise to V0 neurons that go on forming the – preBotzinger complex (preBotC) -- the inspiratory rhythm generator. I now study, via monosynaptic viral tracing in early postnatal mice, the premotor neurons that interface the rhythm generator to output phrenic motor neurons innervating the main inspiratory pump muscle, the diaphragm. I show that the principal premotor neurons in the – rostral ventral respiratory group (rVRG) – are also V0 interneurons. This work reveals an organization of inspiratory circuits in which V0 cell lineages are crucial for establishing (i) the preBotC (rhythm generator) and the rVRG (rhythm follower) and (ii) a connectivity design that secures the bilaterally balanced amplitude and temporal synchronicity of rhythmic phrenic motor drives necessary for efficient breathing." @default.
- W2728395985 created "2017-07-14" @default.
- W2728395985 creator A5010413894 @default.
- W2728395985 date "2016-06-28" @default.
- W2728395985 modified "2023-10-02" @default.
- W2728395985 title "Neural Bases of Breathing in the Mouse : Monosynaptic Tracing and Genetic Dissection of Phrenic Premotor Neurons" @default.
- W2728395985 hasPublicationYear "2016" @default.
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