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- W2728508750 abstract "10 Tumor necrosis factor-alpha (TNF, 1 nM) and angiotensin II (Ang II, 100 nM) increased the DNA content of vascular smooth muscle cell (vsmc) derived from rat thoracic aorta (control: 3.7 ± 0.2, TNF: 5.7 ± 0.7, Ang II: 6.2 ± 0.5 arbitrary units; p 4 cells; p 4 cells; p 2 ) synthesis was increased approximately 3- and 8-fold, in response to TNF or Ang II, respectively, (control: 200 ± 35, TNF: 705 ± 28 pg 6-keto PGF1α/ml; p 2 levels also were significantly reduced by these inhibitors, suggesting a tight coupling of COX-2 to PGI 2 synthesis in these cells. TNF and Ang II induced modest increases in vsmc TXA 2 synthesis (control: 33 ± 3, TNF: 49 ± 3, Ang II: 46 ± 6; p 2 synthesis was not affected. Despite the relatively small increases in TXA 2 synthesis, the TXA 2 receptor antagonist, BMS 180,291 (1 μM) inhibited the proliferative response to Ang II and TNF by >95%. These data suggest that a COX-2-dependent increase in TXA 2 synthesis may contribute to vsmc hyperplasia in pathophysiological conditions associated with elevated levels of either TNF or Ang II. In contrast, PGI 2 may contribute to a compensatory mechanism to limit the proliferative effects of cytokines such as TNF or vasoactive peptides such as Ang II." @default.
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- W2728508750 date "2000-10-01" @default.
- W2728508750 modified "2023-09-26" @default.
- W2728508750 title "Regulation of Vascular Smooth Muscle Cell Proliferation by Cyclooxygenase-2-Derived Prostanoids." @default.
- W2728508750 doi "https://doi.org/10.1161/01.hyp.36.suppl_1.679" @default.
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