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• W2728727235 abstract "ABSTRACT Investigation of alternative phenotypes, different morphologies produced by a single genome, has contributed novel insights into development and evolution. Yet, the mechanisms underlying developmental switch points between alternative phenotypes remain poorly understood. The calyptraeid snails Crepidula navicella and Calyptraea lichen produce two phenotypes: viable and nutritive embryos, where nutritive embryos arrest their development after gastrulation and are ingested by their viable siblings as a form of intracapsular nutrition. Here, we investigate the activity of mitogen‐activated protein kinase (MAPK, ERK1/2) and apoptosis during early cleavage. MAPK and apoptosis, found in a previous transcriptomic study, are known to be involved in organization of other spiralian embryos and nutritive embryo development, respectively. In the model Crepidula fornicata , MAPK activation begins at the 16‐cell stage. In contrast, we discovered in C. navicella and C. lichen that many embryos begin MAPK activation at the one‐cell stage. A subset of embryos shows a similar pattern of MAPK activation to C. fornicata at later stages. In all stages where MAPK is detected, the activation pattern is highly variable, frequently occurring in all quadrants or in multiple tiers of cells. We also detected apoptosis in cleaving embryos, while C. fornicata and Crepidula lessoni , which do not produce nutritive embryos, show no signs of apoptosis during cleavage. Our results show that MAPK and apoptosis are expressed during early development in species with nutritive embryos, and raises the possibility that these processes may play a role and even interact with one another in producing the nutritive embryo phenotype." @default.
• W2728727235 created "2017-07-14" @default.
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• W2728727235 date "2017-06-28" @default.
• W2728727235 modified "2023-10-14" @default.
• W2728727235 title "Early Activation of MAPK and Apoptosis in Nutritive Embryos of Calyptraeid Gastropods" @default.
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• W2728727235 doi "https://doi.org/10.1002/jez.b.22745" @default.
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