FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2728750122> ?p ?o ?g. }

• W2728750122 endingPage "184" @default.
• W2728750122 startingPage "174" @default.
• W2728750122 abstract "Aerva lanata (L.) of the family Amaranthaceae is a Nigerian medicinal plant used traditionally for the management of lithiasis, headache, renal disorder, haematemesis, bronchitis, nasal bleeding, cough, scorpion stings, fractures and spermatorrhoea. Studies that show the pharmacological basis for some of such uses have been reported. There is, however, no scientific report on its toxicity profile to the best of our knowledge. This study was therefore aimed at investigating the toxicity profile of the aqueous extract of Aerva lanata. Acute toxicity tests for the extract administered orally at 1−30 g/kg and intraperitoneally at 0.1−2 g/kg were carried out in albino mice; while a sub-chronic toxicity test was done by daily oral administration of the extract at 40−1000 mg/kg to albino rats for 90 days. Anthropometric, biochemical and haematological parameters’ assessments as well as vital organs histological examinations were performed in the sub-chronic toxicity study. The LD50 of the extract for oral and intraperitoneal acute toxicity tests were 22.62 g/kg and 0.432 g/kg respectively. The extract produced apparent changes in body weights of both male and female rats and significantly (p < 0.05) increased the weights of lungs, brain and pancreas of female rats while reducing the weight of testes in male rats. Haematological parameters were also altered with total leukocytes significantly (p < 0.05) increased and platelets significantly (p < 0.05) reduced in female rats; while neutrophils significantly (p < 0.05) increased in male rats. The extract (40−1000 mg/kg) produced significant (p < 0.05) reduction of serum alanine transaminase concentration in both male and female rats. Aspartate transaminases and albumin were also significantly (p < 0.05) reduced in both male (at 1000 mg/kg) and female (at 200 mg/kg) rats. Alkaline phosphatase was also significantly (p < 0.05) reduced in female rats at 200 mg/kg of the extract. Substantial alterations of creatinine, urea and uric acid were also observed. Triglyceride and cholesterol concentrations were significantly increased in male rats but decreased in female rats. At 1000 mg/kg, the extract significantly elevated catalase and superoxide dismutase levels with no effect on malondialdehyde levels. It also reduced sperm count and motility of male rats. Mild to moderate cellular changes in the brain, kidney, liver, lungs, spleen and testes of treated rats were observed on histological examinations. Significant changes in biochemical and haematological parameters were also noted in treated animals when compared to control animals 30 days after cessation of treatment. The overall findings of this study suggest that the aqueous extract of A. lanata is relatively safe on acute oral exposure, moderately toxic on acute intraperitoneal administration and is relatively safe with antioxidant actions on prolonged exposure. It however shows potentials for toxic effects such as cellular damage to organs, dyslipidaemia and reduction in male reproductive capacity. Caution must therefore be applied in its use on a long term basis." @default.
• W2728750122 created "2017-07-14" @default.
• W2728750122 creator A5010069523 @default.
• W2728750122 creator A5043650227 @default.
• W2728750122 creator A5046832365 @default.
• W2728750122 creator A5057146339 @default.
• W2728750122 creator A5058051354 @default.
• W2728750122 date "2017-08-01" @default.
• W2728750122 modified "2023-09-27" @default.
• W2728750122 title "Toxicological evaluation of the aqueous whole plant extract of Aerva lanata (l.) Juss. ex Schult (Amaranthaceae)" @default.
• W2728750122 cites W1580718844 @default.
• W2728750122 cites W1590457525 @default.
• W2728750122 cites W1898032589 @default.
• W2728750122 cites W1963813937 @default.
• W2728750122 cites W1964394027 @default.
• W2728750122 cites W1973141811 @default.
• W2728750122 cites W1973899663 @default.
• W2728750122 cites W1984203905 @default.
• W2728750122 cites W1993873667 @default.
• W2728750122 cites W1996810630 @default.
• W2728750122 cites W1999429797 @default.
• W2728750122 cites W2010993971 @default.
• W2728750122 cites W2016614782 @default.
• W2728750122 cites W2019713199 @default.
• W2728750122 cites W2025096795 @default.
• W2728750122 cites W2026132332 @default.
• W2728750122 cites W2028072174 @default.
• W2728750122 cites W2028074894 @default.
• W2728750122 cites W2037782869 @default.
• W2728750122 cites W2040017850 @default.
• W2728750122 cites W2042464457 @default.
• W2728750122 cites W2044806264 @default.
• W2728750122 cites W2050090966 @default.
• W2728750122 cites W2050863089 @default.
• W2728750122 cites W2055225004 @default.
• W2728750122 cites W2057664321 @default.
• W2728750122 cites W2058405358 @default.
• W2728750122 cites W2063576996 @default.
• W2728750122 cites W2063680724 @default.
• W2728750122 cites W2064553107 @default.
• W2728750122 cites W2064569282 @default.
• W2728750122 cites W2071140179 @default.
• W2728750122 cites W2072864252 @default.
• W2728750122 cites W2074675672 @default.
• W2728750122 cites W2075067341 @default.
• W2728750122 cites W2076477812 @default.
• W2728750122 cites W2077093369 @default.
• W2728750122 cites W2080787879 @default.
• W2728750122 cites W2081137234 @default.
• W2728750122 cites W2083747309 @default.
• W2728750122 cites W2085519764 @default.
• W2728750122 cites W2089159155 @default.
• W2728750122 cites W2096795975 @default.
• W2728750122 cites W2105321779 @default.
• W2728750122 cites W2106342447 @default.
• W2728750122 cites W2129714366 @default.
• W2728750122 cites W2129999337 @default.
• W2728750122 cites W2130693016 @default.
• W2728750122 cites W2155913334 @default.
• W2728750122 cites W2160839608 @default.
• W2728750122 cites W2161849974 @default.
• W2728750122 cites W2168916475 @default.
• W2728750122 cites W2169014312 @default.
• W2728750122 cites W2184637134 @default.
• W2728750122 cites W2319240824 @default.
• W2728750122 cites W2404885704 @default.
• W2728750122 cites W4255926920 @default.
• W2728750122 doi "https://doi.org/10.1016/j.jep.2017.06.032" @default.
• W2728750122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28668647" @default.
• W2728750122 hasPublicationYear "2017" @default.
• W2728750122 type Work @default.
• W2728750122 sameAs 2728750122 @default.
• W2728750122 citedByCount "13" @default.
• W2728750122 countsByYear W27287501222018 @default.
• W2728750122 countsByYear W27287501222019 @default.
• W2728750122 countsByYear W27287501222020 @default.
• W2728750122 countsByYear W27287501222021 @default.
• W2728750122 countsByYear W27287501222022 @default.
• W2728750122 countsByYear W27287501222023 @default.
• W2728750122 crossrefType "journal-article" @default.
• W2728750122 hasAuthorship W2728750122A5010069523 @default.
• W2728750122 hasAuthorship W2728750122A5043650227 @default.
• W2728750122 hasAuthorship W2728750122A5046832365 @default.
• W2728750122 hasAuthorship W2728750122A5057146339 @default.
• W2728750122 hasAuthorship W2728750122A5058051354 @default.
• W2728750122 hasConcept C116263406 @default.
• W2728750122 hasConcept C126322002 @default.
• W2728750122 hasConcept C2777056448 @default.
• W2728750122 hasConcept C2780590819 @default.
• W2728750122 hasConcept C29730261 @default.
• W2728750122 hasConcept C556039675 @default.
• W2728750122 hasConcept C59822182 @default.
• W2728750122 hasConcept C71924100 @default.
• W2728750122 hasConcept C86803240 @default.
• W2728750122 hasConcept C98274493 @default.
• W2728750122 hasConceptScore W2728750122C116263406 @default.
• W2728750122 hasConceptScore W2728750122C126322002 @default.
• W2728750122 hasConceptScore W2728750122C2777056448 @default.

• next