FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2728759824> ?p ?o ?g. }

• W2728759824 endingPage "145" @default.
• W2728759824 startingPage "138" @default.
• W2728759824 abstract "Babesia bovis BOV57, which is a homolog of the Theileria parva vaccine candidate antigen P67, is expressed in both the tick and blood stages of the life cycle of this parasite. However, the vaccine potential of BOV57 remained to be investigated. In the present study, we generated recombinant BOV57 (rBOV57) and prepared polyclonal antibodies against rBOV57 in mice and rabbits. Indirect immunofluorescence assays conducted with the mouse anti-rBOV57 antibody demonstrated that BOV57 localized at the apical end of paired merozoites in infected bovine red blood cells, whereas the antigen was found in the parasite membrane around the apical end of intraerythrocytic single and extracellular merozoites. In an invasion-inhibition assay, the rabbit anti-rBOV57 antibody potentially inhibited RBC invasion of B. bovis merozoites in vitro. In addition, the invasion inhibition mediated by rabbit anti-rBOV57 antibody resulted in a reduced growth rate of B. bovis in the in vitro culture. These findings indicated that B. bovis BOV57 plays a critical role in the invasion of merozoites into red blood cells, suggesting its potential as a subunit vaccine candidate against B. bovis infection in cattle. Furthermore, we analyzed the genetic diversity of bov57 gene sequences isolated from Sri Lanka, Mongolia, the Philippines, and Vietnam. The bov57 gene sequences derived from Mongolia, the Philippines, and Vietnam were conserved, whereas insertion and/or deletion mutations resulted in sequence diversity among the Sri Lankan samples. In summary, BOV57 is an invasion-related, neutralization-sensitive antigen encoded by the bov57 gene, which displays higher sequence diversity than previously reported." @default.
• W2728759824 created "2017-07-14" @default.
• W2728759824 creator A5013220405 @default.
• W2728759824 creator A5020358761 @default.
• W2728759824 creator A5028365307 @default.
• W2728759824 creator A5047364318 @default.
• W2728759824 creator A5055636688 @default.
• W2728759824 creator A5071344338 @default.
• W2728759824 creator A5085099174 @default.
• W2728759824 creator A5086254349 @default.
• W2728759824 creator A5090430304 @default.
• W2728759824 date "2017-10-01" @default.
• W2728759824 modified "2023-09-27" @default.
• W2728759824 title "Babesia bovis BOV57, a Theileria parva P67 homolog, is an invasion-related, neutralization-sensitive antigen" @default.
• W2728759824 cites W1866735113 @default.
• W2728759824 cites W1932288069 @default.
• W2728759824 cites W1987461073 @default.
• W2728759824 cites W1995529477 @default.
• W2728759824 cites W1996340011 @default.
• W2728759824 cites W1999025627 @default.
• W2728759824 cites W2004695052 @default.
• W2728759824 cites W2009856478 @default.
• W2728759824 cites W2016746408 @default.
• W2728759824 cites W2019866621 @default.
• W2728759824 cites W2022538161 @default.
• W2728759824 cites W2023711373 @default.
• W2728759824 cites W2034767282 @default.
• W2728759824 cites W2042558531 @default.
• W2728759824 cites W2044822018 @default.
• W2728759824 cites W2045689426 @default.
• W2728759824 cites W2048502006 @default.
• W2728759824 cites W2060000061 @default.
• W2728759824 cites W2064009327 @default.
• W2728759824 cites W2064935523 @default.
• W2728759824 cites W2070880434 @default.
• W2728759824 cites W2073678051 @default.
• W2728759824 cites W2083617979 @default.
• W2728759824 cites W2085626961 @default.
• W2728759824 cites W2109352464 @default.
• W2728759824 cites W2111869141 @default.
• W2728759824 cites W2119800861 @default.
• W2728759824 cites W2124666695 @default.
• W2728759824 cites W2126974779 @default.
• W2728759824 cites W2127774996 @default.
• W2728759824 cites W2133627748 @default.
• W2728759824 cites W2134423539 @default.
• W2728759824 cites W2135045784 @default.
• W2728759824 cites W2144510669 @default.
• W2728759824 cites W2146212344 @default.
• W2728759824 cites W2147595745 @default.
• W2728759824 cites W2147838733 @default.
• W2728759824 cites W2152207030 @default.
• W2728759824 cites W2153505764 @default.
• W2728759824 cites W2162518989 @default.
• W2728759824 cites W2164201234 @default.
• W2728759824 cites W2164762368 @default.
• W2728759824 cites W2169173314 @default.
• W2728759824 cites W2314617377 @default.
• W2728759824 cites W2342122804 @default.
• W2728759824 doi "https://doi.org/10.1016/j.meegid.2017.06.025" @default.
• W2728759824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28668608" @default.
• W2728759824 hasPublicationYear "2017" @default.
• W2728759824 type Work @default.
• W2728759824 sameAs 2728759824 @default.
• W2728759824 citedByCount "3" @default.
• W2728759824 countsByYear W27287598242019 @default.
• W2728759824 countsByYear W27287598242020 @default.
• W2728759824 countsByYear W27287598242023 @default.
• W2728759824 crossrefType "journal-article" @default.
• W2728759824 hasAuthorship W2728759824A5013220405 @default.
• W2728759824 hasAuthorship W2728759824A5020358761 @default.
• W2728759824 hasAuthorship W2728759824A5028365307 @default.
• W2728759824 hasAuthorship W2728759824A5047364318 @default.
• W2728759824 hasAuthorship W2728759824A5055636688 @default.
• W2728759824 hasAuthorship W2728759824A5071344338 @default.
• W2728759824 hasAuthorship W2728759824A5085099174 @default.
• W2728759824 hasAuthorship W2728759824A5086254349 @default.
• W2728759824 hasAuthorship W2728759824A5090430304 @default.
• W2728759824 hasBestOaLocation W27287598241 @default.
• W2728759824 hasConcept C136764020 @default.
• W2728759824 hasConcept C147483822 @default.
• W2728759824 hasConcept C153911025 @default.
• W2728759824 hasConcept C159047783 @default.
• W2728759824 hasConcept C159654299 @default.
• W2728759824 hasConcept C203014093 @default.
• W2728759824 hasConcept C2776111823 @default.
• W2728759824 hasConcept C2777119855 @default.
• W2728759824 hasConcept C2778227789 @default.
• W2728759824 hasConcept C2780581805 @default.
• W2728759824 hasConcept C41008148 @default.
• W2728759824 hasConcept C71928629 @default.
• W2728759824 hasConcept C86803240 @default.
• W2728759824 hasConcept C956191 @default.
• W2728759824 hasConceptScore W2728759824C136764020 @default.
• W2728759824 hasConceptScore W2728759824C147483822 @default.
• W2728759824 hasConceptScore W2728759824C153911025 @default.
• W2728759824 hasConceptScore W2728759824C159047783 @default.
• W2728759824 hasConceptScore W2728759824C159654299 @default.

• next