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- W2728843417 abstract "Two key aspects of our approach to identification of endocrine, metabolic and pharmacokinetic systems are presented and applied to experimental studies of thyroid hormone distribution and metabolism dynamics in the rat and human. First, we use unidentifiable but 'parametrically isomorphic' topologies for realistically structuring our models. The additional technical problems introduced by this structuring approach are then partially overcome by introducing additional a priori information, in the form of physico-chemically based inequality constraints, to obtain 'quasi-identiflability,' in special cases, and physiologically or clinically useful parameter space boundaries in general. Second, we use a sequential optimization method for kinetic experiment design, based on an information matrix scheme, that provides maximally accurate models, consistent with usually severe data limitations (a 'small-sample' theory for dynamic systems). Our results to date have uncovered some remarkable similarities in thyroid hormone distribution and metabolism between the laboratory rat and the human species." @default.
- W2728843417 created "2017-07-14" @default.
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- W2728843417 date "1982-06-01" @default.
- W2728843417 modified "2023-09-24" @default.
- W2728843417 title "Comprehensive Dynamics of Distribution and Metabolism of Thyroid Hormones in Blood and Tissue Pools Using Sequentially Optimized Experiment Designs And A Priori Inequality Analyses" @default.
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- W2728843417 doi "https://doi.org/10.1016/s1474-6670(17)63130-6" @default.
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