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• W2728991271 abstract "The excretory function of the liver has been tested clinically by the excretion of the dye in the urine or by the retention in the blood stream. The following dye is suitable for these purposes as Nakagawa10) suggested. The dye which is eliminated in the bile and not in the urine in most useful in the test by the retention in the blood stream, while, for testing by the urine, it is preferable that the greater part of the dye is excreted in the bile and only a small proportion in the urine in normal condition, but that an increased output and a prolonged duration in the urine are found when the liver is disturbed. Moreover, it is most advisable for the test that the dye is stable and non-toxic for human body and presents a distinct tone of colour favourable in determining colorimetrically. It is considered from the elimination in the bile and urine in dogs that MB and IC are unsuitable as the dye. AS is stable and non-toxic and presents a brilliant red available for determination. In normal dogs, over 72% of the dye is excreted in the bile and about 10% in the urine, while the output in the urine increases remarkably with a moderate retention in the blood in the liver disturbance, especially by' chloroform. I found the same results clinically as in, the animal experiments, showing an ideal dye for testing by the urine. As Numasawa4) already stated, BPB is also applied for the same object as AS. Moreover, we1) can distinguish by photoelectric colorimeter more exactly the difference of concentration in BPB as compared with AS, though it has double tone of colour which gives no great difficulty in determination. BS has also the same tendency of excretion as AS in the normal condition of bile-fistula dogs. However, in the liver disturbance, especially by chloroform, the retention in the blood is more remarkable than the increase of excretion in the urine as compared with AS.. Moreover, the dye presents a suitable tone of colour for determination, and I found high percentage of disturbance clinically. From these facts, BS is one of the most available in the test by the retention in the blood. CR is useful in testing by means of blood, for the greater part of the dye is eliminated in the bile and there is no and a little trace of the colour in the urine in normal condition and the liver disturbance, respectively. However, not only high retention but also prolonged removal from the blood are observed in normal condition as compared with AS, BPB, BS and RB. Moreover, it is peculiar that a positive result is obtained in a healthy person and that no interrelation is indicated between the disturbanceS with CR and with other dyes in patients." @default.
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• W2728991271 date "1952-01-01" @default.
• W2728991271 modified "2023-10-04" @default.
• W2728991271 title "Experimental and Clinical Studies on Dyes for Excretory Function Test of Liver" @default.
• W2728991271 doi "https://doi.org/10.1620/tjem.56.87" @default.
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