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• W2729005237 abstract "The film forming gel, adhered to skin surfaces upon application and formed a film, has an advantage onto skin to provide protection and continuous drug release to the application site. This study aimed to prepare a chitosan-based film forming gel containing ketoprofen (CbFG) and to evaluate the CbFG and film from CbFG (CbFG-film). CbFG were prepared with chitosan, lactic acid and various skin permeation enhancers. The physicochemical characteristics were evaluated by texture analysis, viscometry, SEM, DSC, XRD and FT-IR. To identify the mechanism of skin permeation, in vitro skin permeation study was conducted with a Franz diffusion cell and excised SD-rat and hairless mouse dorsal skin. In vivo efficacy assessment in mono-iodoacetate (MIA)-induced rheumatoid arthritis animal model was also conducted. CbFG was successfully prepared and, after applying CbFG to the excised rat dorsal skin, the CbFG-film was also formed well. The physicochemical characteristics of CbFG and CbFG-film could be explained by the grafting of oleic acid onto chitosan in the absence of catalysts. In addition, CbFG containing oleic acid had a higher skin permeation rate in comparison with any other candidate enhancers. The in vivo efficacy study also confirmed significant anti-inflammatory and analgesic effects. Consequently, we report the successful preparation of chitosan-based film forming gel containing ketoprofen with excellent mechanical properties, skin permeation and anti-inflammatory and analgesic effects." @default.
• W2729005237 created "2017-07-14" @default.
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• W2729005237 date "2017-01-01" @default.
• W2729005237 modified "2023-10-15" @default.
• W2729005237 title "Formulation and <i>in vitro</i>/<i>in vivo</i> evaluation of chitosan-based film forming gel containing ketoprofen" @default.
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• W2729005237 doi "https://doi.org/10.1080/10717544.2017.1346001" @default.
• W2729005237 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8241006" @default.
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