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- W2729088210 abstract "Abstract Preserved eggs are widely used as an anti-inflammatory food in dietary therapy. The objective of the present study is to evaluate the effects of simulated gastrointestinal digest from preserved egg white (SGD-PEW) on an in vitro model of tumor necrosis factor (TNF)-α-induced inflammation in Caco-2 cells and a mouse model of dextran sodium sulfate-induced colitis. Results showed that SGD-PEW inhibited the secretion of interleukin (IL)-8, reduced TNF-α-induced expression of genes, including TNF-α, IL-6, IL-1β, interferon gamma (IFN-γ), and IL-17, which are involved in inflammation, and upregulated the expression of the anti-inflammatory cytokines, such as IL-10, in Caco-2 cells. In mice, the treatment of SGD-PEW significantly reduced the clinical signs, weight loss, shortening of the colon and histological scores and downregulated the gene expression of pro-inflammatory cytokines, including TNF-α, IL-6, IL-1β, IFN-γ, and IL-17, in the colon. Thus, SGD-PEW may be a novel preventative food for the treatment of intestinal inflammation." @default.
- W2729088210 created "2017-07-14" @default.
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- W2729088210 date "2017-08-01" @default.
- W2729088210 modified "2023-09-23" @default.
- W2729088210 title "Simulated gastrointestinal digest from preserved egg white exerts anti-inflammatory effects on Caco-2 cells and a mouse model of DSS-induced colitis" @default.
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- W2729088210 doi "https://doi.org/10.1016/j.jff.2017.06.028" @default.
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