FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2729144834> ?p ?o ?g. }

• W2729144834 endingPage "1421" @default.
• W2729144834 startingPage "1414" @default.
• W2729144834 abstract "We recently reported the presence of anti–aquaporin 5 (AQP5) immunoglobulin G (IgG) in patients with primary Sjögren syndrome (SS) with a sensitivity of 0.73 and a specificity of 0.68. The aim of this study was to identify functional epitopes for the anti-AQP5 autoantibodies detected in control subjects and patients with SS. Recognition of epitopes by anti-AQP5 autoantibodies in sera (n = 13 for control and n = 24 for SS) or purified IgG (n = 1 for control and n = 3 for SS) was evaluated by indirect immunofluorescence (IIF) assay performed in the presence or absence of peptides corresponding to the second transmembrane helix and extracellular loops A, C, and E of AQP5. Functional epitopes were determined by measuring the effects of purified IgG and neutralizing peptides on transepithelial osmotic permeability (PfT) of MDCK cells expressing AQP5. In the IIF assay, 89% of SS samples were inhibited by at least 1 peptide, while only half of control samples were inhibited by any peptide. Overall, SS samples were inhibited by peptides corresponding to extracellular loops A, C, and E by 40% to 50%, whereas control samples were inhibited only by peptides corresponding to loop E by <20%. A cyclized peptide (E1) mimicking loop E was most frequently recognized and best differentiated between the SS and control samples. Incubation of MDCK-AQP5 cells with SS but not with control IgG, significantly decreased PfT, which was reversed by neutralization of IgG binding to any of the extracellular loops. In conclusion, the anti-AQP5 autoantibodies detected in control and SS groups showed differences in fine specificity to the functional epitopes of AQP5. The prevalent recognition of functional epitopes by anti-AQP5 autoantibodies from SS patients suggests that anti-AQP5 autoantibodies act as mediators of glandular hypofunction and are a potential therapeutic target in SS." @default.
• W2729144834 created "2017-07-14" @default.
• W2729144834 creator A5000063580 @default.
• W2729144834 creator A5013683329 @default.
• W2729144834 creator A5019364318 @default.
• W2729144834 creator A5071454819 @default.
• W2729144834 creator A5072084297 @default.
• W2729144834 creator A5081904554 @default.
• W2729144834 date "2017-06-30" @default.
• W2729144834 modified "2023-09-30" @default.
• W2729144834 title "Functional Epitopes for Anti–Aquaporin 5 Antibodies in Sjögren Syndrome" @default.
• W2729144834 cites W112689046 @default.
• W2729144834 cites W1966013870 @default.
• W2729144834 cites W1976724711 @default.
• W2729144834 cites W1981443259 @default.
• W2729144834 cites W1983169664 @default.
• W2729144834 cites W1997124000 @default.
• W2729144834 cites W2002335276 @default.
• W2729144834 cites W2006547485 @default.
• W2729144834 cites W2020942539 @default.
• W2729144834 cites W2030711090 @default.
• W2729144834 cites W2036178205 @default.
• W2729144834 cites W2045611996 @default.
• W2729144834 cites W2064836049 @default.
• W2729144834 cites W2071488647 @default.
• W2729144834 cites W2074749052 @default.
• W2729144834 cites W2086332272 @default.
• W2729144834 cites W2087203633 @default.
• W2729144834 cites W2088071723 @default.
• W2729144834 cites W2094723680 @default.
• W2729144834 cites W2097876435 @default.
• W2729144834 cites W2111795509 @default.
• W2729144834 cites W2116941191 @default.
• W2729144834 cites W2126617463 @default.
• W2729144834 cites W2126910812 @default.
• W2729144834 cites W2160247557 @default.
• W2729144834 cites W2165091323 @default.
• W2729144834 cites W2167385753 @default.
• W2729144834 cites W2279108578 @default.
• W2729144834 cites W2291089350 @default.
• W2729144834 cites W2608100403 @default.
• W2729144834 cites W4249353334 @default.
• W2729144834 doi "https://doi.org/10.1177/0022034517717965" @default.
• W2729144834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28665757" @default.
• W2729144834 hasPublicationYear "2017" @default.
• W2729144834 type Work @default.
• W2729144834 sameAs 2729144834 @default.
• W2729144834 citedByCount "15" @default.
• W2729144834 countsByYear W27291448342017 @default.
• W2729144834 countsByYear W27291448342018 @default.
• W2729144834 countsByYear W27291448342019 @default.
• W2729144834 countsByYear W27291448342021 @default.
• W2729144834 countsByYear W27291448342022 @default.
• W2729144834 countsByYear W27291448342023 @default.
• W2729144834 crossrefType "journal-article" @default.
• W2729144834 hasAuthorship W2729144834A5000063580 @default.
• W2729144834 hasAuthorship W2729144834A5013683329 @default.
• W2729144834 hasAuthorship W2729144834A5019364318 @default.
• W2729144834 hasAuthorship W2729144834A5071454819 @default.
• W2729144834 hasAuthorship W2729144834A5072084297 @default.
• W2729144834 hasAuthorship W2729144834A5081904554 @default.
• W2729144834 hasConcept C101180180 @default.
• W2729144834 hasConcept C153911025 @default.
• W2729144834 hasConcept C159654299 @default.
• W2729144834 hasConcept C163764329 @default.
• W2729144834 hasConcept C185592680 @default.
• W2729144834 hasConcept C195616568 @default.
• W2729144834 hasConcept C203014093 @default.
• W2729144834 hasConcept C2778236600 @default.
• W2729144834 hasConcept C2779281246 @default.
• W2729144834 hasConcept C2780898057 @default.
• W2729144834 hasConcept C28406088 @default.
• W2729144834 hasConcept C55493867 @default.
• W2729144834 hasConcept C86803240 @default.
• W2729144834 hasConceptScore W2729144834C101180180 @default.
• W2729144834 hasConceptScore W2729144834C153911025 @default.
• W2729144834 hasConceptScore W2729144834C159654299 @default.
• W2729144834 hasConceptScore W2729144834C163764329 @default.
• W2729144834 hasConceptScore W2729144834C185592680 @default.
• W2729144834 hasConceptScore W2729144834C195616568 @default.
• W2729144834 hasConceptScore W2729144834C203014093 @default.
• W2729144834 hasConceptScore W2729144834C2778236600 @default.
• W2729144834 hasConceptScore W2729144834C2779281246 @default.
• W2729144834 hasConceptScore W2729144834C2780898057 @default.
• W2729144834 hasConceptScore W2729144834C28406088 @default.
• W2729144834 hasConceptScore W2729144834C55493867 @default.
• W2729144834 hasConceptScore W2729144834C86803240 @default.
• W2729144834 hasIssue "12" @default.
• W2729144834 hasLocation W27291448341 @default.
• W2729144834 hasLocation W27291448342 @default.
• W2729144834 hasOpenAccess W2729144834 @default.
• W2729144834 hasPrimaryLocation W27291448341 @default.
• W2729144834 hasRelatedWork W1980697709 @default.
• W2729144834 hasRelatedWork W1998234751 @default.
• W2729144834 hasRelatedWork W2105183547 @default.
• W2729144834 hasRelatedWork W2129500325 @default.
• W2729144834 hasRelatedWork W2184265427 @default.
• W2729144834 hasRelatedWork W2347967465 @default.

• next