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• W2729338968 abstract "Abstract BACKGROUND Digital subtraction angiography (DSA) currently provides angioarchitectural features of cerebral arteriovenous malformations (AVMs) but its role in the hemodynamic evaluation of AVMs is poorly understood. OBJECTIVE To assess contrast time-density time (TT) on DSA relative to AVM flow measured using quantitative magnetic resonance angiography (QMRA). METHODS Patients seen at our institution between 2007 and 2014 with a supratentorial AVM and DSA and QMRA obtained prior to any treatment were retrospectively reviewed. Regions of interest were selected on the draining veins at the point closest to the nidus. TT on DSA was defined as time needed for contrast to change image intensity from 10% to 100%, 100% to 10%, and 25% to 25%. TT was correlated to AVM total flow, angioarchitectural features, and hemorrhage. RESULTS Twenty-eight patients (mean age 35.6 yr) were included. Six patients presented with hemorrhage. Mean AVM volume was 11.42 mL (range 0.3-57.7 mL). Higher total AVM flow significantly correlated with shorter TT 100%-10% and TT 25%-25% ( P = .02, .02, respectively). Presence of venous stenosis correlated significantly with shorter TT 100%-10% ( P = .04) and TT 25%-25% ( P = .04). AVMs with a single draining vein exhibited longer TT 25%-25% compared to those with multiple draining veins ( P = .04). Ruptured AVMs had significantly shorter TT 10%-100% compared to unruptured AVMs ( P = .05). CONCLUSION TT on DSA correlates with cerebral AVM flow measured using QMRA and with AVM angioarchitecture and hemorrhagic presentation. Thus, TT may be used to indirectly estimate AVM flow during angiography in real-time and may also be an indicator of important AVM characteristics associated with outflow resistance and increased rupture risk, such as venous stenosis." @default.
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• W2729338968 date "2017-07-06" @default.
• W2729338968 modified "2023-10-17" @default.
• W2729338968 title "Contrast Time-Density Time on Digital Subtraction Angiography Correlates With Cerebral Arteriovenous Malformation Flow Measured by Quantitative Magnetic Resonance Angiography, Angioarchitecture, and Hemorrhage" @default.
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• W2729338968 doi "https://doi.org/10.1093/neuros/nyx351" @default.
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