FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2729536480> ?p ?o ?g. }

• W2729536480 endingPage "180" @default.
• W2729536480 startingPage "171" @default.
• W2729536480 abstract "With the purpose of enriched drug-loading and controlled drug release, a lysozyme-actived nanodiamond-methotrexate prodrug (ND-PEG-GLY-MTX, NPGM) was designed based on ester linkage between glycidylated (GLYlated) nanodiamond and methotrexate (MTX). The resulting NPGM nanoparticles exhibited a high drug load capacity and excellent stability in the physiological environment. In vitro drug release profile demonstrated that MTX could be greatly released from NPGM nanoparticles in acidic environment containing lysozyme, implying the ester bond of NPGM was broken. Confocal microscope and flow cytometer showed that NPGM entered the cells via time, temperature-dependent, energy independent and caveolin-mediated endocytosis and laid in the lysosomes of the cell. Interestingly, the cytotoxicity of NPGM nanoparticles (OFF) in the extracellular medium could be acitived (ON) by lysozyme in lysosomes, due to cleavage of ester linkages when NPGM entered tumor cells. Furthermore, MTT assay and apoptosis detection uncovered that NPGM had better therapeutic effect than that of free MTX. The results show that the well-defined NPGM is a controlled release drug nanoplatform for tumor treatment and the NPGM will open the new nanodrugs window for a broad covalent coupling spectrum of anticancer agents." @default.
• W2729536480 created "2017-07-14" @default.
• W2729536480 creator A5005920075 @default.
• W2729536480 creator A5009238822 @default.
• W2729536480 creator A5018125351 @default.
• W2729536480 creator A5023073333 @default.
• W2729536480 creator A5024224819 @default.
• W2729536480 creator A5076240648 @default.
• W2729536480 date "2017-08-01" @default.
• W2729536480 modified "2023-10-18" @default.
• W2729536480 title "Enhanced anticancer activity of an intracellularly activatable nanomedicine based on GLYlated nanodiamond" @default.
• W2729536480 cites W1834247112 @default.
• W2729536480 cites W1969859202 @default.
• W2729536480 cites W1986218064 @default.
• W2729536480 cites W1990429716 @default.
• W2729536480 cites W1993074974 @default.
• W2729536480 cites W2000890453 @default.
• W2729536480 cites W2003336829 @default.
• W2729536480 cites W2008515696 @default.
• W2729536480 cites W2017742898 @default.
• W2729536480 cites W2018277314 @default.
• W2729536480 cites W2032595450 @default.
• W2729536480 cites W2032760352 @default.
• W2729536480 cites W2048725729 @default.
• W2729536480 cites W2053305748 @default.
• W2729536480 cites W2056696921 @default.
• W2729536480 cites W2066539222 @default.
• W2729536480 cites W2068115483 @default.
• W2729536480 cites W2069036703 @default.
• W2729536480 cites W2070124760 @default.
• W2729536480 cites W2079407968 @default.
• W2729536480 cites W2082355295 @default.
• W2729536480 cites W2086439684 @default.
• W2729536480 cites W2089984379 @default.
• W2729536480 cites W2097150247 @default.
• W2729536480 cites W2104428958 @default.
• W2729536480 cites W2116972515 @default.
• W2729536480 cites W2130002810 @default.
• W2729536480 cites W2138966657 @default.
• W2729536480 cites W2159098445 @default.
• W2729536480 cites W2159319256 @default.
• W2729536480 cites W2320966902 @default.
• W2729536480 cites W2335034336 @default.
• W2729536480 cites W2465682927 @default.
• W2729536480 cites W2491457559 @default.
• W2729536480 cites W4231616200 @default.
• W2729536480 cites W645197258 @default.
• W2729536480 doi "https://doi.org/10.1016/j.diamond.2017.07.003" @default.
• W2729536480 hasPublicationYear "2017" @default.
• W2729536480 type Work @default.
• W2729536480 sameAs 2729536480 @default.
• W2729536480 citedByCount "14" @default.
• W2729536480 countsByYear W27295364802018 @default.
• W2729536480 countsByYear W27295364802019 @default.
• W2729536480 countsByYear W27295364802020 @default.
• W2729536480 countsByYear W27295364802021 @default.
• W2729536480 countsByYear W27295364802022 @default.
• W2729536480 countsByYear W27295364802023 @default.
• W2729536480 crossrefType "journal-article" @default.
• W2729536480 hasAuthorship W2729536480A5005920075 @default.
• W2729536480 hasAuthorship W2729536480A5009238822 @default.
• W2729536480 hasAuthorship W2729536480A5018125351 @default.
• W2729536480 hasAuthorship W2729536480A5023073333 @default.
• W2729536480 hasAuthorship W2729536480A5024224819 @default.
• W2729536480 hasAuthorship W2729536480A5076240648 @default.
• W2729536480 hasConcept C108215921 @default.
• W2729536480 hasConcept C109316439 @default.
• W2729536480 hasConcept C12554922 @default.
• W2729536480 hasConcept C139770010 @default.
• W2729536480 hasConcept C1491633281 @default.
• W2729536480 hasConcept C15083742 @default.
• W2729536480 hasConcept C155672457 @default.
• W2729536480 hasConcept C171250308 @default.
• W2729536480 hasConcept C178790620 @default.
• W2729536480 hasConcept C180577832 @default.
• W2729536480 hasConcept C185592680 @default.
• W2729536480 hasConcept C192562407 @default.
• W2729536480 hasConcept C202751555 @default.
• W2729536480 hasConcept C2776921476 @default.
• W2729536480 hasConcept C2776966407 @default.
• W2729536480 hasConcept C2777366897 @default.
• W2729536480 hasConcept C2777715892 @default.
• W2729536480 hasConcept C28005876 @default.
• W2729536480 hasConcept C55493867 @default.
• W2729536480 hasConcept C86803240 @default.
• W2729536480 hasConceptScore W2729536480C108215921 @default.
• W2729536480 hasConceptScore W2729536480C109316439 @default.
• W2729536480 hasConceptScore W2729536480C12554922 @default.
• W2729536480 hasConceptScore W2729536480C139770010 @default.
• W2729536480 hasConceptScore W2729536480C1491633281 @default.
• W2729536480 hasConceptScore W2729536480C15083742 @default.
• W2729536480 hasConceptScore W2729536480C155672457 @default.
• W2729536480 hasConceptScore W2729536480C171250308 @default.
• W2729536480 hasConceptScore W2729536480C178790620 @default.
• W2729536480 hasConceptScore W2729536480C180577832 @default.
• W2729536480 hasConceptScore W2729536480C185592680 @default.
• W2729536480 hasConceptScore W2729536480C192562407 @default.
• W2729536480 hasConceptScore W2729536480C202751555 @default.

• next