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• W2729669209 abstract "The therapeutic landscape of Non Small Lung Cancer (NSCLC) has been profoundly changed over the last decade with the clinical introduction of Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitors (TKIs) and the discovery of EGFR activating mutations as the major predictive factor to these agents. Despite impressive clinical activity against EGFR-mutated NSCLCs, the benefit seen with 1st and 2nd generation EGFR TKIs is usually transient and virtually all patients become resistant. Several different mechanisms of acquired resistance have been reported to date, but the vast majority of patients develop a secondary exon 20 mutation in the ATP-binding site of EGFR, namely T790M. The discovery of mutant-selective EGFR TKIs that selectively inhibit EGFR-mutants, including T790M-harboring NSCLCs, while sparing EGFR wild type, provide the opportunity for overcoming the major mechanism of acquired resistance to 1st and 2nd generation EGFR TKIs, with a relatively favorable toxicity profile. The development of this novel class of EGFR inhibitors poses novel challenges in the rapidly evolving therapeutic paradigm of EGFR-mutated NSCLCs and the next few years will witness the beginning of a new era for EGFR inhibition in lung cancer. The aim of this paper is to provide a comprehensive overview of the increasing body of data emerging from the ongoing clinical trials with this promising novel therapeutic class of EGFR inhibitors." @default.
• W2729669209 created "2017-07-14" @default.
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• W2729669209 creator A5089680689 @default.
• W2729669209 date "2017-09-01" @default.
• W2729669209 modified "2023-10-16" @default.
• W2729669209 title "Third generation EGFR TKIs in EGFR-mutated NSCLC: Where are we now and where are we going" @default.
• W2729669209 cites W1546552389 @default.
• W2729669209 cites W1584059175 @default.
• W2729669209 cites W1607191560 @default.
• W2729669209 cites W1690635788 @default.
• W2729669209 cites W1904060183 @default.
• W2729669209 cites W1908940658 @default.
• W2729669209 cites W1940083515 @default.
• W2729669209 cites W1942770305 @default.
• W2729669209 cites W1963826141 @default.
• W2729669209 cites W1972842161 @default.
• W2729669209 cites W1980497534 @default.
• W2729669209 cites W1983774108 @default.
• W2729669209 cites W1987283660 @default.
• W2729669209 cites W1987575156 @default.
• W2729669209 cites W1990013637 @default.
• W2729669209 cites W1990938833 @default.
• W2729669209 cites W2002937040 @default.
• W2729669209 cites W2003984225 @default.
• W2729669209 cites W2027735722 @default.
• W2729669209 cites W2032397471 @default.
• W2729669209 cites W2032712631 @default.
• W2729669209 cites W2035495099 @default.
• W2729669209 cites W2050211354 @default.
• W2729669209 cites W2054020870 @default.
• W2729669209 cites W2062766483 @default.
• W2729669209 cites W2065293650 @default.
• W2729669209 cites W2067064694 @default.
• W2729669209 cites W2076178766 @default.
• W2729669209 cites W2087955215 @default.
• W2729669209 cites W2088540000 @default.
• W2729669209 cites W2095811566 @default.
• W2729669209 cites W2096198395 @default.
• W2729669209 cites W2096540669 @default.
• W2729669209 cites W2096786080 @default.
• W2729669209 cites W2098395191 @default.
• W2729669209 cites W2102088611 @default.
• W2729669209 cites W2103563973 @default.
• W2729669209 cites W2108371618 @default.
• W2729669209 cites W2109080255 @default.
• W2729669209 cites W2110841878 @default.
• W2729669209 cites W2113508099 @default.
• W2729669209 cites W2117784514 @default.
• W2729669209 cites W2126177831 @default.
• W2729669209 cites W2126709309 @default.
• W2729669209 cites W2128385295 @default.
• W2729669209 cites W2129656399 @default.
• W2729669209 cites W2133149289 @default.
• W2729669209 cites W2133283856 @default.
• W2729669209 cites W2133963438 @default.
• W2729669209 cites W2138089710 @default.
• W2729669209 cites W2139799027 @default.
• W2729669209 cites W2143574474 @default.
• W2729669209 cites W2143913849 @default.
• W2729669209 cites W2145980885 @default.
• W2729669209 cites W2146418087 @default.
• W2729669209 cites W2150575159 @default.
• W2729669209 cites W2152905269 @default.
• W2729669209 cites W2153080167 @default.
• W2729669209 cites W2154149901 @default.
• W2729669209 cites W2156647409 @default.
• W2729669209 cites W2159013299 @default.
• W2729669209 cites W2160300997 @default.
• W2729669209 cites W2160982674 @default.
• W2729669209 cites W2166084034 @default.
• W2729669209 cites W2167934111 @default.
• W2729669209 cites W2169105660 @default.
• W2729669209 cites W2169460814 @default.
• W2729669209 cites W2169745966 @default.
• W2729669209 cites W2169816570 @default.
• W2729669209 cites W2171139285 @default.
• W2729669209 cites W2257614390 @default.
• W2729669209 cites W2270997383 @default.
• W2729669209 cites W2292347930 @default.
• W2729669209 cites W2336745060 @default.
• W2729669209 cites W2337507927 @default.
• W2729669209 cites W2338078784 @default.
• W2729669209 cites W2340070077 @default.
• W2729669209 cites W2342166807 @default.
• W2729669209 cites W2400274474 @default.
• W2729669209 cites W2416111151 @default.
• W2729669209 cites W2468983064 @default.
• W2729669209 cites W2494292000 @default.
• W2729669209 cites W2527757234 @default.
• W2729669209 cites W2890271519 @default.
• W2729669209 cites W2890605354 @default.

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