FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2729894982> ?p ?o ?g. }

• W2729894982 endingPage "626" @default.
• W2729894982 startingPage "623" @default.
• W2729894982 abstract ": To investigate the prevalence of bleeding in heterozygotes for prothrombin deficiencies. Homozygotes or compound heterozygotes with Factor II (FII) levels of less than 10% of normal are always severely symptomatic.On the contrary little is known about the heterozygous population who have FII levels around 40-50% of normal.Forty-four patients heterozygous for this defect, in comparison with age and sex matched 44 unaffected family members, have been followed during a mean observational period of 22.5 years (range 4-35 years). The study was carried out in Padua between the years 1971 and 2010.The mean prothrombin activity was 0.49 IU/dl (range 0.38-0.62) and 0.91 IU/dl (range 0.81-1.10) in the heterozygotes and in the normal counterparts, respectively.In total, 14 patients showed bleeding manifestations vs. only three among the controls. Bleeding was sometimes spontaneous but more frequently occurred after tooth extractions, surgery, or delivery.Some heterozygous patients had also to be given replacement therapy to control the bleeding. No substitution therapy was ever needed for the normal counterparts.The prothrombin activity levels in the patients who were symptomatic tended to be lower than in those who remained asymptomatic.The difference in the frequency of bleeding and in the bleeding score between patients and unaffected family members was statistically significant (P = 0.007 and 0.0007).Prothrombin levels of about 40-50% of normal may not represent well tolerated hemostatic levels in case of surgical procedures, tooth extraction, or delivery. These data may have general clinical significance even for patients who have acquired defects." @default.
• W2729894982 created "2017-07-14" @default.
• W2729894982 creator A5015164112 @default.
• W2729894982 creator A5023752222 @default.
• W2729894982 creator A5035924186 @default.
• W2729894982 creator A5042444993 @default.
• W2729894982 creator A5046561459 @default.
• W2729894982 creator A5056029238 @default.
• W2729894982 date "2017-12-01" @default.
• W2729894982 modified "2023-09-23" @default.
• W2729894982 title "Bleeding manifestations in heterozygotes with prothrombin deficiency or abnormalities vs. unaffected family members as observed during a long follow-up study" @default.
• W2729894982 cites W1492931178 @default.
• W2729894982 cites W1493526661 @default.
• W2729894982 cites W1794261056 @default.
• W2729894982 cites W1926341681 @default.
• W2729894982 cites W1966951431 @default.
• W2729894982 cites W1972341359 @default.
• W2729894982 cites W1977392455 @default.
• W2729894982 cites W1981206546 @default.
• W2729894982 cites W1986229343 @default.
• W2729894982 cites W1988624263 @default.
• W2729894982 cites W1995845350 @default.
• W2729894982 cites W2008187686 @default.
• W2729894982 cites W2009520402 @default.
• W2729894982 cites W2022225356 @default.
• W2729894982 cites W2032296051 @default.
• W2729894982 cites W2038098687 @default.
• W2729894982 cites W2074524815 @default.
• W2729894982 cites W2079416873 @default.
• W2729894982 cites W2080104937 @default.
• W2729894982 cites W2089137088 @default.
• W2729894982 cites W2092087640 @default.
• W2729894982 cites W2095438864 @default.
• W2729894982 cites W2097310719 @default.
• W2729894982 cites W2137135882 @default.
• W2729894982 cites W2344919086 @default.
• W2729894982 cites W2412820600 @default.
• W2729894982 cites W2419669024 @default.
• W2729894982 cites W2460204813 @default.
• W2729894982 cites W2587031517 @default.
• W2729894982 doi "https://doi.org/10.1097/mbc.0000000000000648" @default.
• W2729894982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28665815" @default.
• W2729894982 hasPublicationYear "2017" @default.
• W2729894982 type Work @default.
• W2729894982 sameAs 2729894982 @default.
• W2729894982 citedByCount "5" @default.
• W2729894982 countsByYear W27298949822018 @default.
• W2729894982 countsByYear W27298949822019 @default.
• W2729894982 countsByYear W27298949822020 @default.
• W2729894982 crossrefType "journal-article" @default.
• W2729894982 hasAuthorship W2729894982A5015164112 @default.
• W2729894982 hasAuthorship W2729894982A5023752222 @default.
• W2729894982 hasAuthorship W2729894982A5035924186 @default.
• W2729894982 hasAuthorship W2729894982A5042444993 @default.
• W2729894982 hasAuthorship W2729894982A5046561459 @default.
• W2729894982 hasAuthorship W2729894982A5056029238 @default.
• W2729894982 hasConcept C104317684 @default.
• W2729894982 hasConcept C12125453 @default.
• W2729894982 hasConcept C126322002 @default.
• W2729894982 hasConcept C141071460 @default.
• W2729894982 hasConcept C153471976 @default.
• W2729894982 hasConcept C180754005 @default.
• W2729894982 hasConcept C2777910003 @default.
• W2729894982 hasConcept C2908647359 @default.
• W2729894982 hasConcept C54355233 @default.
• W2729894982 hasConcept C71924100 @default.
• W2729894982 hasConcept C86803240 @default.
• W2729894982 hasConcept C90924648 @default.
• W2729894982 hasConcept C99454951 @default.
• W2729894982 hasConceptScore W2729894982C104317684 @default.
• W2729894982 hasConceptScore W2729894982C12125453 @default.
• W2729894982 hasConceptScore W2729894982C126322002 @default.
• W2729894982 hasConceptScore W2729894982C141071460 @default.
• W2729894982 hasConceptScore W2729894982C153471976 @default.
• W2729894982 hasConceptScore W2729894982C180754005 @default.
• W2729894982 hasConceptScore W2729894982C2777910003 @default.
• W2729894982 hasConceptScore W2729894982C2908647359 @default.
• W2729894982 hasConceptScore W2729894982C54355233 @default.
• W2729894982 hasConceptScore W2729894982C71924100 @default.
• W2729894982 hasConceptScore W2729894982C86803240 @default.
• W2729894982 hasConceptScore W2729894982C90924648 @default.
• W2729894982 hasConceptScore W2729894982C99454951 @default.
• W2729894982 hasIssue "8" @default.
• W2729894982 hasLocation W27298949821 @default.
• W2729894982 hasLocation W27298949822 @default.
• W2729894982 hasOpenAccess W2729894982 @default.
• W2729894982 hasPrimaryLocation W27298949821 @default.
• W2729894982 hasRelatedWork W1969766260 @default.
• W2729894982 hasRelatedWork W1995188757 @default.
• W2729894982 hasRelatedWork W2057721052 @default.
• W2729894982 hasRelatedWork W2082239176 @default.
• W2729894982 hasRelatedWork W2103018930 @default.
• W2729894982 hasRelatedWork W2899084033 @default.
• W2729894982 hasRelatedWork W3018830891 @default.
• W2729894982 hasRelatedWork W4229900919 @default.
• W2729894982 hasRelatedWork W4240077505 @default.
• W2729894982 hasRelatedWork W4252472287 @default.
• W2729894982 hasVolume "28" @default.

• next