Matches in SemOpenAlex for { <https://semopenalex.org/work/W2729909209> ?p ?o ?g. }
- W2729909209 endingPage "441" @default.
- W2729909209 startingPage "434" @default.
- W2729909209 abstract "Malignant hyperthermia (MH), a pharmacogenetic disorder of skeletal muscle, presents with a potentially lethal hypermetabolic reaction to certain anesthetics. However, some MH-susceptible patients experience muscle weakness, fatigue, and exercise intolerance in the absence of anesthetic triggers. The objective of this exploratory study was to elucidate the pathophysiology of exercise intolerance in patients tested positive for MH with the caffeine-halothane contracture test. To this end, we used phosphorus magnetic resonance spectroscopy, blood oxygen level-dependent functional magnetic resonance imaging (MRI), and traditional exercise testing to compare skeletal muscle metabolism in MH-positive patients and healthy controls.Skeletal muscle metabolism was assessed using phosphorus magnetic resonance spectroscopy and blood oxygen level-dependent functional MRI in 29 MH-positive patients and 20 healthy controls. Traditional measures of physical capacity were employed to measure aerobic capacity, anaerobic capacity, and muscle strength.During 30- and 60-second exercise, MH-positive patients had significantly lower ATP production via the oxidative pathway compared to healthy controls. MH-positive patients also had a longer recovery time with blood oxygen level-dependent functional MRI compared to healthy controls. Exercise testing revealed lower aerobic and anaerobic capacity in MH-positive patients compared to healthy controls.Results of this exploratory study suggest that MH-positive patients have impaired aerobic metabolism compared to healthy individuals. This could explain the exercise intolerance exhibited in MH-susceptible patient population." @default.
- W2729909209 created "2017-07-14" @default.
- W2729909209 creator A5002935727 @default.
- W2729909209 creator A5009481067 @default.
- W2729909209 creator A5016497325 @default.
- W2729909209 creator A5019160382 @default.
- W2729909209 creator A5048208735 @default.
- W2729909209 creator A5064806494 @default.
- W2729909209 creator A5074228294 @default.
- W2729909209 creator A5088392079 @default.
- W2729909209 date "2017-08-01" @default.
- W2729909209 modified "2023-09-24" @default.
- W2729909209 title "Skeletal Muscle Metabolic Dysfunction in Patients With Malignant Hyperthermia Susceptibility" @default.
- W2729909209 cites W112814453 @default.
- W2729909209 cites W135858439 @default.
- W2729909209 cites W1509344561 @default.
- W2729909209 cites W1517114309 @default.
- W2729909209 cites W1811034586 @default.
- W2729909209 cites W1968019508 @default.
- W2729909209 cites W1971279461 @default.
- W2729909209 cites W1978547646 @default.
- W2729909209 cites W1979978572 @default.
- W2729909209 cites W1989228624 @default.
- W2729909209 cites W1990020089 @default.
- W2729909209 cites W1991203132 @default.
- W2729909209 cites W1996689777 @default.
- W2729909209 cites W1998402137 @default.
- W2729909209 cites W2004506564 @default.
- W2729909209 cites W2017415739 @default.
- W2729909209 cites W2017903490 @default.
- W2729909209 cites W2026055104 @default.
- W2729909209 cites W2032159687 @default.
- W2729909209 cites W2052339507 @default.
- W2729909209 cites W2054591037 @default.
- W2729909209 cites W2060972605 @default.
- W2729909209 cites W2063511102 @default.
- W2729909209 cites W2064583449 @default.
- W2729909209 cites W2071608199 @default.
- W2729909209 cites W2078093155 @default.
- W2729909209 cites W2091685634 @default.
- W2729909209 cites W2099614270 @default.
- W2729909209 cites W2101758219 @default.
- W2729909209 cites W2107560389 @default.
- W2729909209 cites W2110894635 @default.
- W2729909209 cites W2111005855 @default.
- W2729909209 cites W2135942278 @default.
- W2729909209 cites W2161515375 @default.
- W2729909209 cites W2163671742 @default.
- W2729909209 cites W2172062766 @default.
- W2729909209 cites W2334331971 @default.
- W2729909209 cites W2399334702 @default.
- W2729909209 cites W4313371759 @default.
- W2729909209 doi "https://doi.org/10.1213/ane.0000000000002232" @default.
- W2729909209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28682948" @default.
- W2729909209 hasPublicationYear "2017" @default.
- W2729909209 type Work @default.
- W2729909209 sameAs 2729909209 @default.
- W2729909209 citedByCount "9" @default.
- W2729909209 countsByYear W27299092092018 @default.
- W2729909209 countsByYear W27299092092019 @default.
- W2729909209 countsByYear W27299092092020 @default.
- W2729909209 countsByYear W27299092092021 @default.
- W2729909209 countsByYear W27299092092022 @default.
- W2729909209 countsByYear W27299092092023 @default.
- W2729909209 crossrefType "journal-article" @default.
- W2729909209 hasAuthorship W2729909209A5002935727 @default.
- W2729909209 hasAuthorship W2729909209A5009481067 @default.
- W2729909209 hasAuthorship W2729909209A5016497325 @default.
- W2729909209 hasAuthorship W2729909209A5019160382 @default.
- W2729909209 hasAuthorship W2729909209A5048208735 @default.
- W2729909209 hasAuthorship W2729909209A5064806494 @default.
- W2729909209 hasAuthorship W2729909209A5074228294 @default.
- W2729909209 hasAuthorship W2729909209A5088392079 @default.
- W2729909209 hasBestOaLocation W27299092092 @default.
- W2729909209 hasConcept C103038586 @default.
- W2729909209 hasConcept C126322002 @default.
- W2729909209 hasConcept C126838900 @default.
- W2729909209 hasConcept C134018914 @default.
- W2729909209 hasConcept C143409427 @default.
- W2729909209 hasConcept C196310339 @default.
- W2729909209 hasConcept C20251656 @default.
- W2729909209 hasConcept C2776418732 @default.
- W2729909209 hasConcept C2777321227 @default.
- W2729909209 hasConcept C2777953023 @default.
- W2729909209 hasConcept C2778198053 @default.
- W2729909209 hasConcept C2778575482 @default.
- W2729909209 hasConcept C2779959927 @default.
- W2729909209 hasConcept C2908647359 @default.
- W2729909209 hasConcept C2992361435 @default.
- W2729909209 hasConcept C42219234 @default.
- W2729909209 hasConcept C42407357 @default.
- W2729909209 hasConcept C5140985 @default.
- W2729909209 hasConcept C55885012 @default.
- W2729909209 hasConcept C62231903 @default.
- W2729909209 hasConcept C71924100 @default.
- W2729909209 hasConcept C84393581 @default.
- W2729909209 hasConcept C99454951 @default.
- W2729909209 hasConceptScore W2729909209C103038586 @default.